ID   ZCH12_BOVIN             Reviewed;         402 AA.
AC   Q08DL1;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Zinc finger CCHC domain-containing protein 12;
GN   Name=ZCCHC12;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal muscle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional coactivator in the bone morphogenetic protein
CC       (BMP)-signaling pathway. It positively modulates BMP signaling by
CC       interacting with SMAD1 and associating with CBP in the transcription
CC       complex. It contributes to the BMP-induced enhancement of cholinergic-
CC       neuron-specific gene expression (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SMAD1 and CREB-binding protein (CBP). Forms a
CC       protein-DNA complex through its association with SMAD1 (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ZCCHC12 family. {ECO:0000305}.
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DR   EMBL; BC123686; AAI23687.1; -; mRNA.
DR   RefSeq; NP_001069665.1; NM_001076197.1.
DR   RefSeq; XP_005227489.1; XM_005227432.3.
DR   AlphaFoldDB; Q08DL1; -.
DR   STRING; 9913.ENSBTAP00000046384; -.
DR   PaxDb; Q08DL1; -.
DR   PRIDE; Q08DL1; -.
DR   Ensembl; ENSBTAT00000049498; ENSBTAP00000046384; ENSBTAG00000035018.
DR   GeneID; 540006; -.
DR   KEGG; bta:540006; -.
DR   CTD; 170261; -.
DR   VEuPathDB; HostDB:ENSBTAG00000035018; -.
DR   VGNC; VGNC:50125; ZCCHC12.
DR   eggNOG; ENOG502RU0T; Eukaryota.
DR   GeneTree; ENSGT01030000234522; -.
DR   HOGENOM; CLU_686127_0_0_1; -.
DR   InParanoid; Q08DL1; -.
DR   OMA; RKHTIRC; -.
DR   OrthoDB; 697027at2759; -.
DR   TreeFam; TF335054; -.
DR   Proteomes; UP000009136; Chromosome X.
DR   Bgee; ENSBTAG00000035018; Expressed in spermatocyte and 89 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR026523; PNMA.
DR   InterPro; IPR036875; Znf_CCHC_sf.
DR   PANTHER; PTHR23095; PTHR23095; 1.
DR   Pfam; PF14893; PNMA; 1.
DR   SUPFAM; SSF57756; SSF57756; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Reference proteome; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..402
FT                   /note="Zinc finger CCHC domain-containing protein 12"
FT                   /id="PRO_0000346786"
FT   ZN_FING         346..363
FT                   /note="CCHC-type"
FT   REGION          268..342
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          383..402
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        307..329
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   402 AA;  45552 MW;  A80104D13086C0B4 CRC64;
     MTSIIARMSN SRRQNTSLPP WAHSMLRSLE RSLGPLMAIL AERNLKLFSG RVVPAQGEET
     FENWLIQVNE VLPDWNMSEE EKLRRLIKTL RGPAREVMLL LQAANPNLSV ADFLHAMKLV
     FGESESSVTA HSKFFNTLQA QGEKASLYVI RLEVQLQNAI QAGIIAQKDA NQSRLHQFLL
     GAELNGDLRF RLKNLLRMYA NEQERLPSFL ELIRMIREEE DWDDIFIKQK RAKRSESVVA
     RATRPVAFGG SPPIVIDNKD CNVIEIDDTP DDSDEDVILV GESQDLPRSF SDSPPSRRRA
     RPQDQVLIID SPNNSQFPSP CTSGGSGYKN DGPGNMRRTR KRKHTIRCSY CGEEGHSKET
     CDNESNKAQM FENLIITLQE LAHTEERSRE APVEPSDPCE LQ