ID   ZCH12_RAT               Reviewed;         401 AA.
AC   Q5HZA3;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Zinc finger CCHC domain-containing protein 12;
GN   Name=Zcchc12;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Transcriptional coactivator in the bone morphogenetic protein
CC       (BMP)-signaling pathway. It positively modulates BMP signaling by
CC       interacting with SMAD1 and associating with CBP in the transcription
CC       complex. It contributes to the BMP-induced enhancement of cholinergic-
CC       neuron-specific gene expression (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SMAD1 and CREB-binding protein (CBP). Forms a
CC       protein-DNA complex through its association with SMAD1 (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ZCCHC12 family. {ECO:0000305}.
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DR   EMBL; BC089115; AAH89115.1; -; mRNA.
DR   RefSeq; NP_001014087.1; NM_001014065.2.
DR   RefSeq; XP_006257510.1; XM_006257448.3.
DR   RefSeq; XP_006257511.1; XM_006257449.3.
DR   RefSeq; XP_006257513.1; XM_006257451.3.
DR   RefSeq; XP_006257514.1; XM_006257452.3.
DR   RefSeq; XP_017457523.1; XM_017602034.1.
DR   RefSeq; XP_017457524.1; XM_017602035.1.
DR   RefSeq; XP_017457525.1; XM_017602036.1.
DR   AlphaFoldDB; Q5HZA3; -.
DR   STRING; 10116.ENSRNOP00000017567; -.
DR   PaxDb; Q5HZA3; -.
DR   PRIDE; Q5HZA3; -.
DR   Ensembl; ENSRNOT00000017567; ENSRNOP00000017567; ENSRNOG00000013162.
DR   Ensembl; ENSRNOT00000094904; ENSRNOP00000077726; ENSRNOG00000013162.
DR   Ensembl; ENSRNOT00000111671; ENSRNOP00000090059; ENSRNOG00000013162.
DR   Ensembl; ENSRNOT00000113244; ENSRNOP00000079816; ENSRNOG00000013162.
DR   GeneID; 313436; -.
DR   KEGG; rno:313436; -.
DR   UCSC; RGD:1359439; rat.
DR   CTD; 170261; -.
DR   RGD; 1359439; Zcchc12.
DR   eggNOG; ENOG502RU0T; Eukaryota.
DR   GeneTree; ENSGT01030000234522; -.
DR   HOGENOM; CLU_686127_0_0_1; -.
DR   InParanoid; Q5HZA3; -.
DR   OMA; RKHTIRC; -.
DR   OrthoDB; 697027at2759; -.
DR   PhylomeDB; Q5HZA3; -.
DR   TreeFam; TF335054; -.
DR   PRO; PR:Q5HZA3; -.
DR   Proteomes; UP000002494; Chromosome X.
DR   Bgee; ENSRNOG00000013162; Expressed in brain and 20 other tissues.
DR   Genevisible; Q5HZA3; RN.
DR   GO; GO:0016607; C:nuclear speck; ISO:RGD.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0016605; C:PML body; ISO:RGD.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0032183; F:SUMO binding; ISO:RGD.
DR   GO; GO:0003713; F:transcription coactivator activity; ISO:RGD.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0030509; P:BMP signaling pathway; ISO:RGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR   InterPro; IPR026523; PNMA.
DR   InterPro; IPR001878; Znf_CCHC.
DR   PANTHER; PTHR23095; PTHR23095; 1.
DR   Pfam; PF14893; PNMA; 1.
DR   PROSITE; PS50158; ZF_CCHC; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Reference proteome; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..401
FT                   /note="Zinc finger CCHC domain-containing protein 12"
FT                   /id="PRO_0000150973"
FT   ZN_FING         345..362
FT                   /note="CCHC-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          270..292
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   401 AA;  45154 MW;  98845C1336208507 CRC64;
     MASILSRMGN SRGQNSPLPP WAHSMLRSLG RSLGPLMASM AERNMKLFSG RAEPAQGEET
     FENWLSQVTA VLPDWHMPEE EKVRRLMRTL RGPAREVMRL LQAANPCLDV EDFLRAMKLV
     FGESESSVTA HSKFVNTVQE PGEKPSLYVI RLEVQLQNAI QAGVFAEREA NQARLHQLLV
     GAEMSTDLRF RLKSLLRVYA NEPERLPNFL ELIRMIREEE EWEEAFIHPK RPRRSQSVER
     ALSPTFQSSP PVMISSIDCN VIEIDDSPDD SDEDVILVEP DDPPLPSSSA GPSFLGRAVS
     EDQVLVIESP NIFEIQAPST SSGAGRKNNN NFGELRRARK RKHTVHCSHC GEEGHSKETC
     DNESDRGQVF ENLIITLQEL THTEERAREI FGEAIGLSEL H