ZCH14_HUMAN
ID ZCH14_HUMAN Reviewed; 949 AA.
AC Q8WYQ9; D3DUN1; O60324; Q3MJD8; Q9UFP0;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Zinc finger CCHC domain-containing protein 14;
DE AltName: Full=BDG-29;
GN Name=ZCCHC14; Synonyms=KIAA0579;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Kawasoe T., Furukawa Y., Daigo Y., Ishiguro H., Nishiwaki T., Fujita M.,
RA Nagasawa Y., Miyoshi Y., Nakamura Y.;
RT "Isolation and characterization of a novel downstream gene of beta-
RT catenin.";
RL Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT MET-693.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 40-949 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=9628581; DOI=10.1093/dnares/5.1.31;
RA Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N.,
RA Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. IX. The
RT complete sequences of 100 new cDNA clones from brain which can code for
RT large proteins in vitro.";
RL DNA Res. 5:31-39(1998).
RN [5]
RP SEQUENCE REVISION.
RX PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT "Construction of expression-ready cDNA clones for KIAA genes: manual
RT curation of 330 KIAA cDNA clones.";
RL DNA Res. 9:99-106(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 118-949 (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [7]
RP VARIANT [LARGE SCALE ANALYSIS] VAL-290.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- INTERACTION:
CC Q8WYQ9; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-3937908, EBI-3867333;
CC Q8WYQ9; Q13643: FHL3; NbExp=3; IntAct=EBI-3937908, EBI-741101;
CC Q8WYQ9; A0A024R8L2: hCG_1987119; NbExp=3; IntAct=EBI-3937908, EBI-14103818;
CC Q8WYQ9; P15173: MYOG; NbExp=3; IntAct=EBI-3937908, EBI-3906629;
CC Q8WYQ9; Q58EX7: PLEKHG4; NbExp=3; IntAct=EBI-3937908, EBI-949255;
CC Q8WYQ9; P86480: PRR20D; NbExp=3; IntAct=EBI-3937908, EBI-12754095;
CC Q8WYQ9; Q63HR2: TNS2; NbExp=3; IntAct=EBI-3937908, EBI-949753;
CC Q8WYQ9; Q70EL1-9: USP54; NbExp=3; IntAct=EBI-3937908, EBI-11975223;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8WYQ9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WYQ9-2; Sequence=VSP_013843;
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DR EMBL; AB030243; BAB83129.1; -; mRNA.
DR EMBL; CH471114; EAW95389.1; -; Genomic_DNA.
DR EMBL; CH471114; EAW95390.1; -; Genomic_DNA.
DR EMBL; BC101478; AAI01479.1; -; mRNA.
DR EMBL; AB011151; BAA25505.2; -; mRNA.
DR EMBL; AL117532; CAB55981.1; -; mRNA.
DR PIR; T17291; T17291.
DR RefSeq; NP_055959.1; NM_015144.2.
DR RefSeq; XP_005255915.2; XM_005255858.3. [Q8WYQ9-2]
DR AlphaFoldDB; Q8WYQ9; -.
DR SMR; Q8WYQ9; -.
DR BioGRID; 116786; 35.
DR IntAct; Q8WYQ9; 10.
DR STRING; 9606.ENSP00000268616; -.
DR GlyGen; Q8WYQ9; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q8WYQ9; -.
DR PhosphoSitePlus; Q8WYQ9; -.
DR BioMuta; ZCCHC14; -.
DR DMDM; 67462073; -.
DR EPD; Q8WYQ9; -.
DR MassIVE; Q8WYQ9; -.
DR MaxQB; Q8WYQ9; -.
DR PaxDb; Q8WYQ9; -.
DR PeptideAtlas; Q8WYQ9; -.
DR PRIDE; Q8WYQ9; -.
DR ProteomicsDB; 75192; -. [Q8WYQ9-1]
DR ProteomicsDB; 75193; -. [Q8WYQ9-2]
DR Antibodypedia; 2893; 68 antibodies from 17 providers.
DR DNASU; 23174; -.
DR Ensembl; ENST00000268616.9; ENSP00000268616.4; ENSG00000140948.13. [Q8WYQ9-1]
DR GeneID; 23174; -.
DR KEGG; hsa:23174; -.
DR UCSC; uc002fjz.2; human. [Q8WYQ9-1]
DR CTD; 23174; -.
DR DisGeNET; 23174; -.
DR GeneCards; ZCCHC14; -.
DR HGNC; HGNC:24134; ZCCHC14.
DR HPA; ENSG00000140948; Low tissue specificity.
DR neXtProt; NX_Q8WYQ9; -.
DR OpenTargets; ENSG00000140948; -.
DR PharmGKB; PA134895795; -.
DR VEuPathDB; HostDB:ENSG00000140948; -.
DR eggNOG; KOG3791; Eukaryota.
DR eggNOG; KOG4400; Eukaryota.
DR GeneTree; ENSGT00520000055637; -.
DR HOGENOM; CLU_014508_0_0_1; -.
DR InParanoid; Q8WYQ9; -.
DR OMA; NFGPRTK; -.
DR OrthoDB; 200084at2759; -.
DR PhylomeDB; Q8WYQ9; -.
DR TreeFam; TF335574; -.
DR PathwayCommons; Q8WYQ9; -.
DR SignaLink; Q8WYQ9; -.
DR BioGRID-ORCS; 23174; 29 hits in 1085 CRISPR screens.
DR ChiTaRS; ZCCHC14; human.
DR GenomeRNAi; 23174; -.
DR Pharos; Q8WYQ9; Tbio.
DR PRO; PR:Q8WYQ9; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q8WYQ9; protein.
DR Bgee; ENSG00000140948; Expressed in secondary oocyte and 206 other tissues.
DR ExpressionAtlas; Q8WYQ9; baseline and differential.
DR Genevisible; Q8WYQ9; HS.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd09558; SAM_ZCCH14; 1.
DR Gene3D; 1.10.150.50; -; 1.
DR Gene3D; 3.30.1520.10; -; 1.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR037632; ZCCH14_SAM.
DR InterPro; IPR042344; ZCCHC14.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR16195; PTHR16195; 1.
DR Pfam; PF00098; zf-CCHC; 1.
DR SMART; SM00343; ZnF_C2HC; 1.
DR SUPFAM; SSF47769; SSF47769; 1.
DR SUPFAM; SSF57756; SSF57756; 1.
DR SUPFAM; SSF64268; SSF64268; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..949
FT /note="Zinc finger CCHC domain-containing protein 14"
FT /id="PRO_0000150975"
FT ZN_FING 906..923
FT /note="CCHC-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT REGION 25..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 59..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 739..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..79
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..411
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..432
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..457
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 739..760
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 933..949
FT /note="TFRLKYAPPAESLDSTD -> KRAPWPRPPGSRRTSAHKCLVFMKSKLLSL
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_013843"
FT VARIANT 54
FT /note="I -> V (in dbSNP:rs11648852)"
FT /id="VAR_053754"
FT VARIANT 244
FT /note="G -> A (in dbSNP:rs13338940)"
FT /id="VAR_053755"
FT VARIANT 290
FT /note="L -> V (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036492"
FT VARIANT 693
FT /note="V -> M (in dbSNP:rs3748400)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_024703"
SQ SEQUENCE 949 AA; 100042 MW; 6770937387359D14 CRC64;
MASNHPAFSF HQKQVLRQEL TQIQSSLNGG GGHGGKGAPG PGGALPTCPA CHKITPRTEA
PVSSVSNSLE NALHTSAHST EESLPKRPLG KHSKVSVEKI DLKGLSHTKN DRNVECSFEV
LWSDSSITSV TKSSSEVTEF ISKLCQLYPE ENLEKLIPCL AGPDAFYVER NHVDLDSGLR
YLASLPSHVL KNDHVRRFLS TSSPPQQLQS PSPGNPSLSK VGTVMGVSGR PVCGVAGIPS
SQSGAQHHGQ HPAGSAAPLP HCSHAGSAGS ALAYRTQMDT SPAILMPSSL QTPQTQEQNG
ILDWLRKLRL HKYYPVFKQL SMEKFLSLTE EDLNKFESLT MGAKKKLKTQ LELEKEKSER
RCLNPSAPPL VTSSGVARVP PTSHVGPVQS GRGSHAAELR VEVEQPHHQL PREGSSSEYS
SSSSSPMGVQ AREESSDSAE ENDRRVEIHL ESSDKEKPVM LLNHFTSSSA RPTAQVLPVQ
NEASSNPSGH HPLPPQMLSA ASHITPIRML NSVHKPERGS ADMKLLSSSV HSLLSLEERN
KGSGPRSSMK VDKSFGSAMM DVLPASAPHQ PVQVLSGLSE SSSMSPTVSF GPRTKVVHAS
TLDRVLKTAQ QPALVVETST AATGTPSTVL HAARPPIKLL LSSSVPADSA ISGQTSCPNN
VQISVPPAII NPRTALYTAN TKVAFSAMSS MPVGPLQGGF CANSNTASPS SHPSTSFANM
ATLPSCPAPS SSPALSSVPE SSFYSSSGGG GSTGNIPASN PNHHHHHHHQ QPPAPPQPAP
PPPGCIVCTS CGCSGSCGSS GLTVSYANYF QHPFSGPSVF TFPFLPFSPM CSSGYVSAQQ
YGGGSTFPVV HAPYSSSGTP DPVLSGQSTF AVPPMQNFMA GTAGVYQTQG LVGSSNGSSH
KKSGNLSCYN CGATGHRAQD CKQPSMDFNR PGTFRLKYAP PAESLDSTD
