ZCH14_MOUSE
ID ZCH14_MOUSE Reviewed; 956 AA.
AC Q8VIG0; Q80TX3; Q91VU4;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Zinc finger CCHC domain-containing protein 14;
DE AltName: Full=BDG-29;
GN Name=Zcchc14; Synonyms=Kiaa0579;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Kawasoe T., Furukawa Y., Daigo Y., Ishiguro H., Nishiwaki T., Fujita M.,
RA Nagasawa Y., Miyoshi Y., Nakamura Y.;
RT "Isolation and characterization of a novel downstream gene of beta-
RT catenin.";
RL Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 704-944 (ISOFORM 2).
RC STRAIN=NMRI; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 790-956 (ISOFORM 3).
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8VIG0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8VIG0-2; Sequence=VSP_013844;
CC Name=3;
CC IsoId=Q8VIG0-3; Sequence=VSP_013845;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH09020.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB030244; BAB83130.1; -; mRNA.
DR EMBL; BC009020; AAH09020.1; ALT_INIT; mRNA.
DR EMBL; AK122315; BAC65597.1; -; mRNA.
DR RefSeq; NP_543131.1; NM_080855.2. [Q8VIG0-1]
DR AlphaFoldDB; Q8VIG0; -.
DR SMR; Q8VIG0; -.
DR BioGRID; 228335; 1.
DR STRING; 10090.ENSMUSP00000040360; -.
DR iPTMnet; Q8VIG0; -.
DR PhosphoSitePlus; Q8VIG0; -.
DR PaxDb; Q8VIG0; -.
DR PRIDE; Q8VIG0; -.
DR ProteomicsDB; 298504; -. [Q8VIG0-1]
DR ProteomicsDB; 298505; -. [Q8VIG0-2]
DR ProteomicsDB; 298506; -. [Q8VIG0-3]
DR Antibodypedia; 2893; 68 antibodies from 17 providers.
DR DNASU; 142682; -.
DR Ensembl; ENSMUST00000046386; ENSMUSP00000040360; ENSMUSG00000061410. [Q8VIG0-1]
DR GeneID; 142682; -.
DR KEGG; mmu:142682; -.
DR UCSC; uc009nrx.2; mouse. [Q8VIG0-1]
DR UCSC; uc009nry.1; mouse. [Q8VIG0-2]
DR CTD; 23174; -.
DR MGI; MGI:2159407; Zcchc14.
DR VEuPathDB; HostDB:ENSMUSG00000061410; -.
DR eggNOG; KOG3791; Eukaryota.
DR eggNOG; KOG4400; Eukaryota.
DR GeneTree; ENSGT00520000055637; -.
DR HOGENOM; CLU_014508_0_0_1; -.
DR InParanoid; Q8VIG0; -.
DR OMA; NFGPRTK; -.
DR OrthoDB; 200084at2759; -.
DR PhylomeDB; Q8VIG0; -.
DR TreeFam; TF335574; -.
DR BioGRID-ORCS; 142682; 15 hits in 72 CRISPR screens.
DR ChiTaRS; Zcchc14; mouse.
DR PRO; PR:Q8VIG0; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8VIG0; protein.
DR Bgee; ENSMUSG00000061410; Expressed in rostral migratory stream and 252 other tissues.
DR ExpressionAtlas; Q8VIG0; baseline and differential.
DR Genevisible; Q8VIG0; MM.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd09558; SAM_ZCCH14; 1.
DR Gene3D; 1.10.150.50; -; 1.
DR Gene3D; 3.30.1520.10; -; 1.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR037632; ZCCH14_SAM.
DR InterPro; IPR042344; ZCCHC14.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR16195; PTHR16195; 1.
DR Pfam; PF00098; zf-CCHC; 1.
DR SMART; SM00343; ZnF_C2HC; 1.
DR SUPFAM; SSF47769; SSF47769; 1.
DR SUPFAM; SSF57756; SSF57756; 1.
DR SUPFAM; SSF64268; SSF64268; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..956
FT /note="Zinc finger CCHC domain-containing protein 14"
FT /id="PRO_0000150976"
FT ZN_FING 913..930
FT /note="CCHC-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT REGION 25..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 78..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 243..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 485..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 750..786
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..222
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 441..464
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..767
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 939..956
FT /note="GTFRLKYAPPAESLDSTD -> EHFIKP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_013844"
FT VAR_SEQ 940..956
FT /note="TFRLKYAPPAESLDSTD -> KQVRGSHVLLALWLVAPERRKQETCFVLFFK
FT MIFIHTVFFFFFFKIYLFIIICTYTEAVFRCTRRGCQTSSRVVVSHHVVAGI (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:12693553"
FT /id="VSP_013845"
SQ SEQUENCE 956 AA; 99835 MW; 9B02F53EFBD5AC6F CRC64;
MASNHPAFSF HQKQVLRQEL TQIQSSLNSG GGGGGGGGGG GKSAPGPSGA LPTCSACHKM
APRTETPVSS ISNSLENALH TSAHSTEESL PKRPLGKHGK VSVEKIDLKG LSHTKNDRSV
ECSFEVLWSD SSITSVTKSS SEVTEFISKL SQLCPEENLD KLIPCLAGPD SFYVERNHVD
LEAGLRFLAS APSHTLKHDH VRKFFSSSSP SQQLQSPSPG NPSLPKVGAV MGVSGRPVCG
VAGIPSSQSS AQHHLQHSAS TSASLPHCSH TGGTGSALAY RTQVDNSPTI LMPSSLQTPQ
PQEQNGILDW LRKLRLHKYY PVFKQLTMEK FLSLTEEDLN KFESLTMGAK KKLKTQLELE
KEKSERRCLN SSAPSLVTSS GVARVTPTSH VGPVQPGRSS SHASELRVEV EPPAHQLPRE
GSSSEYSSSS SSPMGVQVRE ESSDSAEESD RRVDIHVEGT EKEKPVMLLA HFPSSSARPT
AQVLPVQNET GSSPAAHHPL PPQLMPAASH LAPVRMLNSV HKSDRGGADV KLLSSSVHSL
LSLEERNKGP GPRSGTKVDK SFGGAVLDPL PSAAPHPPGQ GLSGLVENNA VSPTVSFGPR
AKVVHAATLD RVLKTAQQPA LTVESSSATT GTPSTVLHVA RPPIKLLLAS SVPADAAIAG
QTSCPNNGQI SVPPAIMNPR TALYTANTKV AFSAVSSVPV GPLQGSFCAN SNTASPSSHP
STSFASMASL PSCPAPSSSP ALSSVPESSF YSGGAGSSSP GNIPASSQSH HHHHHHQQPP
APPQPAPPPP GCIVCTSCGC SGSCGSNGLT VSYANYFQHP FSGPSVLTFP FLPFSPMCGN
GYVSTQQYGG GSAFPVVHTP YNGSVTPDPV LGGQSTFAVP PMQNFMAGTA GVYQAQGLVG
STNGSSHKKS GNLSCYNCGA TGHRAQDCKQ PSMDFNRQGT FRLKYAPPAE SLDSTD
