ZCH18_DANRE
ID ZCH18_DANRE Reviewed; 1148 AA.
AC Q1LUE5;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Zinc finger CCCH domain-containing protein 18;
GN Name=zc3h18; ORFNames=si:ch211-218c6.1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-666 AND SER-1056, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18307296; DOI=10.1021/pr700667w;
RA Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B., den Hertog J.,
RA Slijper M., Heck A.J.R.;
RT "Online automated in vivo zebrafish phosphoproteomics: from large-scale
RT analysis down to a single embryo.";
RL J. Proteome Res. 7:1555-1564(2008).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL935038; CAK04265.1; -; Genomic_DNA.
DR EMBL; BX950194; CAK04265.1; JOINED; Genomic_DNA.
DR EMBL; BX950194; CAK04529.1; -; Genomic_DNA.
DR EMBL; AL935038; CAK04529.1; JOINED; Genomic_DNA.
DR RefSeq; NP_001037804.1; NM_001044339.2.
DR AlphaFoldDB; Q1LUE5; -.
DR STRING; 7955.ENSDARP00000122210; -.
DR iPTMnet; Q1LUE5; -.
DR PaxDb; Q1LUE5; -.
DR PRIDE; Q1LUE5; -.
DR Ensembl; ENSDART00000090446; ENSDARP00000084879; ENSDARG00000062506.
DR Ensembl; ENSDART00000141873; ENSDARP00000122210; ENSDARG00000062506.
DR GeneID; 555770; -.
DR KEGG; dre:555770; -.
DR CTD; 124245; -.
DR ZFIN; ZDB-GENE-050419-13; zc3h18.
DR eggNOG; ENOG502R7WP; Eukaryota.
DR GeneTree; ENSGT00730000111190; -.
DR HOGENOM; CLU_012901_0_0_1; -.
DR InParanoid; Q1LUE5; -.
DR OrthoDB; 618568at2759; -.
DR PhylomeDB; Q1LUE5; -.
DR TreeFam; TF327301; -.
DR PRO; PR:Q1LUE5; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 18.
DR Bgee; ENSDARG00000062506; Expressed in early embryo and 28 other tissues.
DR ExpressionAtlas; Q1LUE5; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW Coiled coil; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..1148
FT /note="Zinc finger CCCH domain-containing protein 18"
FT /id="PRO_0000311245"
FT REGION 1..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 380..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..1127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 543..584
FT /evidence="ECO:0000255"
FT COILED 1118..1146
FT /evidence="ECO:0000255"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..99
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..203
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..243
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..292
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..308
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..617
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 636..656
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 677..754
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..821
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 822..837
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 843..905
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 927..966
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1013..1054
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 666
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18307296"
FT MOD_RES 1056
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18307296"
SQ SEQUENCE 1148 AA; 129172 MW; B3E0D362EF7C503A CRC64;
MDTPESPTQS PQSPEEEEKG LSDNELLESP ESPAEADKGV SDSELLNDDE NEVPEHGGDS
DSEDRDRQPA GREDPEELSD VEDYKLDREE REDIHQQEGA LRVQEIAQKA IKSPEEEILE
TPRSPDPVSP AAEHERPFTP AEEERGDDDE EEEEDETTTK SGLGQAELEE EEDEEEERRR
RRRAAMVVSD LKDESSVSRD LDEHELDYDE EVPEEPSAAA PEEDEPEKPA VGEDGEDEEE
EDEEEEKRRK RKERKPILPP DNRDTPLRKS EDSREGGRRD SFRDKKKEED DGEIDEGEID
DDDLEEGEVK DPMDRKIRPR PICRFFMKGS FVTMYGNVKF FFFKSYLVFL TGNCTWGMIC
RFIHPGVNDK GNYSLISKPD PFSPNGAPPG GAAGGGPHPL MPANPWGAPA VEELPPPPPP
LDPPVESAWE RGLRHAKEVL KKATIRKEQE PDFEEKRFTV TIGEDDRDFD KENDFFRERG
GYRITREIRD AGSDPYGDPY YDYEMEAFWR GGQYENFRVQ YTETPLPYYP DRERERDPRE
RHRERERERE RDHRERERRQ RERERERERE REKDSRRRKD EWDRDRLKRD EKEGRPRERP
LREPREKKDE KEKTLKPRSP TNMPPRGPME PPTKKDMLSV TKRPDEWNDP WCRSKSPRRR
PGFMGSPPRG RRRHRPSGSS VSLSNSSRSS SRSSSFTGSG SSRSRSRSRS SSMSSYSSHS
SQHSSFSGSR SRSGSFSSSP SPSPSAQRNA NKNKAEQPPA AAKGPPLKPG ALPPPRRDKG
PPKVMPSPSL PEQPGKPPKP ITETVKPPNP RPPGRPPGPR EPREPPNMRE GRKKERQQHN
PPRRRTVSGS VSGSSYSGSS SRSRSRSSSA SASRSGSHKS RSLSVSSVSS VSSASSSSSS
VRSADSDDMY ADLASPVSSA SSRSPTPGHP RKDRGPPRER GPNKERGKPP KKDEPFKDER
KRVDPSGLPS KASSDMPRSG NRGHPMHPPP MGPPGGYGSH KDIKLTLLNK QQTDRSNRKR
YFPSDKERPP SPLRKRMAMS PDGGRDRRMP GRPPMSPRME RPKGQGPRPM PSQGERKRPL
SPPAKSSGKG PAAASAAKPP APGAGSGSAS GSAPGKPSST LSRREELLKQ LKAVEDAIAR
KRAKIPGK
