CC159_MOUSE
ID CC159_MOUSE Reviewed; 411 AA.
AC Q8C963; Q0VBB7; Q9CXZ5; Q9D4W5;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Coiled-coil domain-containing protein 159;
GN Name=Ccdc159;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Liver, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8C963-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8C963-2; Sequence=VSP_033427;
CC Name=3;
CC IsoId=Q8C963-3; Sequence=VSP_033428, VSP_033429;
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DR EMBL; AK011114; BAB27409.1; -; mRNA.
DR EMBL; AK016073; BAB30102.1; -; mRNA.
DR EMBL; AK042884; BAC31391.1; -; mRNA.
DR EMBL; BC120702; AAI20703.1; -; mRNA.
DR EMBL; BC120704; AAI20705.1; -; mRNA.
DR CCDS; CCDS40557.1; -. [Q8C963-2]
DR CCDS; CCDS52738.1; -. [Q8C963-1]
DR RefSeq; NP_001158086.1; NM_001164614.1. [Q8C963-1]
DR RefSeq; NP_080253.2; NM_025977.3. [Q8C963-2]
DR AlphaFoldDB; Q8C963; -.
DR SMR; Q8C963; -.
DR STRING; 10090.ENSMUSP00000126474; -.
DR iPTMnet; Q8C963; -.
DR PhosphoSitePlus; Q8C963; -.
DR PaxDb; Q8C963; -.
DR PRIDE; Q8C963; -.
DR ProteomicsDB; 265292; -. [Q8C963-1]
DR ProteomicsDB; 265293; -. [Q8C963-2]
DR ProteomicsDB; 265294; -. [Q8C963-3]
DR Antibodypedia; 52093; 16 antibodies from 8 providers.
DR Ensembl; ENSMUST00000006403; ENSMUSP00000006403; ENSMUSG00000006241. [Q8C963-2]
DR Ensembl; ENSMUST00000170304; ENSMUSP00000126474; ENSMUSG00000006241. [Q8C963-1]
DR Ensembl; ENSMUST00000214734; ENSMUSP00000150744; ENSMUSG00000006241. [Q8C963-3]
DR GeneID; 67119; -.
DR KEGG; mmu:67119; -.
DR UCSC; uc009omx.1; mouse. [Q8C963-2]
DR UCSC; uc009omy.2; mouse. [Q8C963-3]
DR UCSC; uc009omz.2; mouse. [Q8C963-1]
DR CTD; 126075; -.
DR MGI; MGI:1914369; Ccdc159.
DR VEuPathDB; HostDB:ENSMUSG00000006241; -.
DR eggNOG; ENOG502S2FS; Eukaryota.
DR GeneTree; ENSGT00390000008201; -.
DR HOGENOM; CLU_686891_0_0_1; -.
DR InParanoid; Q8C963; -.
DR OMA; QKECCND; -.
DR OrthoDB; 1360515at2759; -.
DR PhylomeDB; Q8C963; -.
DR TreeFam; TF337495; -.
DR BioGRID-ORCS; 67119; 0 hits in 72 CRISPR screens.
DR PRO; PR:Q8C963; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q8C963; protein.
DR Bgee; ENSMUSG00000006241; Expressed in seminiferous tubule of testis and 69 other tissues.
DR ExpressionAtlas; Q8C963; baseline and differential.
DR Genevisible; Q8C963; MM.
DR InterPro; IPR039284; CCDC159/163.
DR PANTHER; PTHR34533; PTHR34533; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..411
FT /note="Coiled-coil domain-containing protein 159"
FT /id="PRO_0000332997"
FT REGION 84..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 372..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 269..305
FT /evidence="ECO:0000255"
FT COMPBIAS 379..394
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..12
FT /note="MGEHERVVCCSS -> MNGC (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_033427"
FT VAR_SEQ 263..267
FT /note="SKKFL -> RGPGG (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033428"
FT VAR_SEQ 268..411
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033429"
FT CONFLICT 55
FT /note="E -> D (in Ref. 1; BAB27409)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 411 AA; 46342 MW; 8E9CA2940FC293AA CRC64;
MGEHERVVCC SSDSLLAGLS RDSDDCVSHL CTPPLLAITS WAAKERSQYS PPPGEPGPSS
DKALDCMTHW SRVLEPEIVN TASEQAGKSG AWEKEWDSEP QPHEGTPCSS SDVNKDHYHD
QDLVKRNHCV AKKSLEPSSA KVKVKNTMII PDSQKLLRCE LESLRSQLQA QSKAFEFLNH
SVTMLEKESC LQQIKIQQLE EVLSPTSRQG EKYGRKWSTE QELYGALAQG LQGLQKTLKE
GEELQRARTT RCLQLLAREI RDSKKFLWEE LELVREEVTF IYQKLQDQED EISENLLNIQ
KMQKTQVKCR KVLTKMKQQA YDSWPEAEGV PTEGNGCCKD DLQKELGDIW SAVHSLQSSI
DCLALSMGTR PRASSLRGQK GHQCKSSQCP SWDSDSDWER PFSKSGSYPP A
