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ZCH24_HUMAN
ID   ZCH24_HUMAN             Reviewed;         241 AA.
AC   Q8N2G6; Q5U5T9; Q8TAG0;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 146.
DE   RecName: Full=Zinc finger CCHC domain-containing protein 24;
GN   Name=ZCCHC24; Synonyms=C10orf56;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Thyroid;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-43.
RC   TISSUE=Brain, and PNS;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA   Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
RT   "Global, in vivo, and site-specific phosphorylation dynamics in signaling
RT   networks.";
RL   Cell 127:635-648(2006).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-93, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Leukemic T-cell;
RX   PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA   Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA   Rodionov V., Han D.K.;
RT   "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT   reveals system-wide modulation of protein-protein interactions.";
RL   Sci. Signal. 2:RA46-RA46(2009).
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH39249.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AK075279; BAC11516.1; -; mRNA.
DR   EMBL; AL133481; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC028617; AAH28617.1; -; mRNA.
DR   EMBL; BC039249; AAH39249.1; ALT_FRAME; mRNA.
DR   EMBL; BC053564; AAH53564.1; -; mRNA.
DR   CCDS; CCDS7359.1; -.
DR   RefSeq; NP_699198.2; NM_153367.3.
DR   AlphaFoldDB; Q8N2G6; -.
DR   BioGRID; 128561; 21.
DR   STRING; 9606.ENSP00000361411; -.
DR   iPTMnet; Q8N2G6; -.
DR   PhosphoSitePlus; Q8N2G6; -.
DR   BioMuta; ZCCHC24; -.
DR   DMDM; 74759814; -.
DR   EPD; Q8N2G6; -.
DR   jPOST; Q8N2G6; -.
DR   MassIVE; Q8N2G6; -.
DR   MaxQB; Q8N2G6; -.
DR   PaxDb; Q8N2G6; -.
DR   PeptideAtlas; Q8N2G6; -.
DR   PRIDE; Q8N2G6; -.
DR   ProteomicsDB; 71696; -.
DR   Antibodypedia; 29874; 126 antibodies from 19 providers.
DR   DNASU; 219654; -.
DR   Ensembl; ENST00000372336.4; ENSP00000361411.3; ENSG00000165424.7.
DR   GeneID; 219654; -.
DR   KEGG; hsa:219654; -.
DR   MANE-Select; ENST00000372336.4; ENSP00000361411.3; NM_153367.4; NP_699198.2.
DR   UCSC; uc001kak.4; human.
DR   CTD; 219654; -.
DR   DisGeNET; 219654; -.
DR   GeneCards; ZCCHC24; -.
DR   HGNC; HGNC:26911; ZCCHC24.
DR   HPA; ENSG00000165424; Tissue enhanced (brain).
DR   neXtProt; NX_Q8N2G6; -.
DR   OpenTargets; ENSG00000165424; -.
DR   PharmGKB; PA162409573; -.
DR   VEuPathDB; HostDB:ENSG00000165424; -.
DR   eggNOG; ENOG502QRVW; Eukaryota.
DR   GeneTree; ENSGT00390000008264; -.
DR   HOGENOM; CLU_081736_0_0_1; -.
DR   InParanoid; Q8N2G6; -.
DR   OMA; NEPAVGH; -.
DR   OrthoDB; 1317500at2759; -.
DR   PhylomeDB; Q8N2G6; -.
DR   TreeFam; TF319664; -.
DR   PathwayCommons; Q8N2G6; -.
DR   BioGRID-ORCS; 219654; 10 hits in 1079 CRISPR screens.
DR   ChiTaRS; ZCCHC24; human.
DR   GenomeRNAi; 219654; -.
DR   Pharos; Q8N2G6; Tdark.
DR   PRO; PR:Q8N2G6; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   RNAct; Q8N2G6; protein.
DR   Bgee; ENSG00000165424; Expressed in inferior vagus X ganglion and 200 other tissues.
DR   ExpressionAtlas; Q8N2G6; baseline and differential.
DR   Genevisible; Q8N2G6; HS.
DR   GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR033446; Zcchc24_Znf-3CxxC.
DR   InterPro; IPR025829; Zn_knuckle_CX2CX3GHX4C.
DR   InterPro; IPR027377; Znf-3CxxC.
DR   InterPro; IPR001878; Znf_CCHC.
DR   InterPro; IPR036875; Znf_CCHC_sf.
DR   Pfam; PF17180; zf-3CxxC_2; 1.
DR   Pfam; PF13696; zf-CCHC_2; 1.
DR   SMART; SM01328; zf-3CxxC; 1.
DR   SUPFAM; SSF57756; SSF57756; 1.
DR   PROSITE; PS50158; ZF_CCHC; 1.
PE   1: Evidence at protein level;
KW   Metal-binding; Phosphoprotein; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..241
FT                   /note="Zinc finger CCHC domain-containing protein 24"
FT                   /id="PRO_0000274289"
FT   ZN_FING         132..149
FT                   /note="CCHC-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT   MOD_RES         65
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:17081983,
FT                   ECO:0007744|PubMed:18669648"
FT   MOD_RES         93
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:19690332"
FT   VARIANT         43
FT                   /note="E -> V (in dbSNP:rs17852581)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_030249"
FT   CONFLICT        48
FT                   /note="A -> T (in Ref. 3; AAH39249)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        152
FT                   /note="P -> T (in Ref. 3; AAH39249)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   241 AA;  26955 MW;  F5C8C8E5AEE241FC CRC64;
     MSLLSAIDTS AASVYQPAQL LNWVYLSLQD THQASAFDAF RPEPTAGAAP PELAFGKGRP
     EQLGSPLHSS YLNSFFQLQR GEALSNSVYK GASPYGSLNN IADGLSSLTE HFSDLTLTSE
     ARKPSKRPPP NYLCHLCFNK GHYIKDCPQA RPKGEGLTPY QGKKRCFGEY KCPKCKRKWM
     SGNSWANMGQ ECIKCHINVY PHKQRPLEKP DGLDVSDQSK EHPQHLCEKC KVLGYYCRRV
     Q
 
 
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