ZCHC2_MOUSE
ID ZCHC2_MOUSE Reviewed; 1166 AA.
AC Q69ZB8; Q7TNF1; Q8CB08;
DT 10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 3.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Zinc finger CCHC domain-containing protein 2;
GN Name=Zcchc2; Synonyms=Kiaa1744;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Thymus;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 482-1166 (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Vagina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 867-1166 (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q69ZB8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q69ZB8-2; Sequence=VSP_013721;
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DR EMBL; AK173248; BAD32526.1; -; mRNA.
DR EMBL; AK037100; BAC29703.1; -; mRNA.
DR EMBL; BC055760; AAH55760.1; -; mRNA.
DR CCDS; CCDS48335.1; -. [Q69ZB8-1]
DR CCDS; CCDS48336.1; -. [Q69ZB8-2]
DR RefSeq; NP_001116147.1; NM_001122675.1. [Q69ZB8-2]
DR RefSeq; NP_001116148.1; NM_001122676.1. [Q69ZB8-1]
DR AlphaFoldDB; Q69ZB8; -.
DR BioGRID; 230628; 1.
DR STRING; 10090.ENSMUSP00000113974; -.
DR iPTMnet; Q69ZB8; -.
DR PhosphoSitePlus; Q69ZB8; -.
DR EPD; Q69ZB8; -.
DR MaxQB; Q69ZB8; -.
DR PaxDb; Q69ZB8; -.
DR PRIDE; Q69ZB8; -.
DR ProteomicsDB; 275272; -. [Q69ZB8-1]
DR ProteomicsDB; 275273; -. [Q69ZB8-2]
DR Antibodypedia; 23063; 20 antibodies from 9 providers.
DR Ensembl; ENSMUST00000118196; ENSMUSP00000113974; ENSMUSG00000038866. [Q69ZB8-1]
DR Ensembl; ENSMUST00000119166; ENSMUSP00000113128; ENSMUSG00000038866. [Q69ZB8-2]
DR GeneID; 227449; -.
DR KEGG; mmu:227449; -.
DR UCSC; uc007cgq.3; mouse. [Q69ZB8-2]
DR UCSC; uc007cgt.3; mouse. [Q69ZB8-1]
DR CTD; 54877; -.
DR MGI; MGI:2444114; Zcchc2.
DR VEuPathDB; HostDB:ENSMUSG00000038866; -.
DR eggNOG; KOG4400; Eukaryota.
DR GeneTree; ENSGT00520000055637; -.
DR HOGENOM; CLU_012453_0_0_1; -.
DR InParanoid; Q69ZB8; -.
DR OMA; RIDKEYN; -.
DR OrthoDB; 200084at2759; -.
DR PhylomeDB; Q69ZB8; -.
DR TreeFam; TF335574; -.
DR BioGRID-ORCS; 227449; 4 hits in 73 CRISPR screens.
DR ChiTaRS; Zcchc2; mouse.
DR PRO; PR:Q69ZB8; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q69ZB8; protein.
DR Bgee; ENSMUSG00000038866; Expressed in secondary oocyte and 219 other tissues.
DR ExpressionAtlas; Q69ZB8; baseline and differential.
DR Genevisible; Q69ZB8; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.1520.10; -; 1.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR042793; ZCCHC2.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR46939; PTHR46939; 1.
DR Pfam; PF00098; zf-CCHC; 1.
DR SMART; SM00343; ZnF_C2HC; 1.
DR SUPFAM; SSF57756; SSF57756; 1.
DR SUPFAM; SSF64268; SSF64268; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..1166
FT /note="Zinc finger CCHC domain-containing protein 2"
FT /id="PRO_0000150950"
FT ZN_FING 1119..1136
FT /note="CCHC-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT REGION 1..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 550..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 904..982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..43
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..67
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..229
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..588
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..635
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 636..656
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 915..948
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 949..963
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 964..982
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1146..1166
FT /note="TYRLRYAPPLPPSNDTLDSAD -> NPTNSQRTCF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15368895,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_013721"
SQ SEQUENCE 1166 AA; 124517 MW; BBE1E89BC7EED4E6 CRC64;
MLRMKLPPKS THPSEPPPDA EEPEADARPG AKAPLRRRRD CRPPPPPTGL PRGPPPPPSP
PRGLEPPVAS GPTAGAGMPG GGGHAAALRE QERVYEWFGL VLGSAQRLEF MCGLLDLCNP
LELRFLGSCL EDLARKDYHY LRDSEAKANG LSDPGSLADF REPAVRSRLI VYLALLGSEN
REAAGRLHRL LPQVDAVLRS LRATRAEGSR GSVEDEPSGD GEQDAEKDGP GPEGSGCAKL
GTGGGLGFRA QEELLLLFTM ASLHPAFSFH QRVTLREHLE RLRSALRVEP EDAEVEPSNF
AGSRAQNDSA CGDYIQSNET GLVEQAQIPP DGLTVAPHRA QREAVHIEKI MLKGVQRKRA
DKYWEYTFKV NWSDLSVTTV TKTHQELQEF LLKLPKEFSS ESFDKTILKA LNQGSLRREE
RRHPDLEPIL RQLFSTSPQA FLQSHKVRSF FRSISSESQH NFNNLQSSLK TSKILEHLKE
DSSEASSQEE DVLQHTIIHK KHAGKSPALN VATSCSPLDG LTMQYAEQNG IVDWRNQGCA
AIQHSEHCVS SADQHSAEKR SLSSGNKKKG KPQVEKEKVK KTEDRLNSRI NGIRLSAPQH
VHGSTVKDMN LDIGSGHDTC GETSSESYSS PSSPRHDGRE SLESEEEKDR DSDSNSEDSV
NPSSARFSGY GSVAQTIAVK PPAETVSLGT EDGNLLEAAL TSHKYPHIPF MPTLHCVTHN
GAQKSQVVIP SPKSADGKTL GMLVPNAVAI SAVMESSNSA PVGILGPAAS GESEKHLELL
ASPLPLPSTF LPHSSAPALQ LTLQSLKLQP PQGSSDSCPV SIPPQPTGSL SIGSPNTAFI
PVHNPGSFPG SPVATTDPIT KSAPQVVGLN QMVPQIEGNT GTVPQPSNVK VVLPAAGLSA
AQPPASFPFP GSPQAASALP TQNSSALNAA TSAQPASTGI SPSQSTVPPA VPTHTPGPAP
SPSPALTHST AQSDSTSYIS AVGNTNANGT IVPPQQMGPC GSCGRRCSCG TNGNLQLNSY
YYPNPMPGPM YRLPSFFTLP SICNGSYLNQ AHQSNGNQLP FFLPQTPYAN GLVHDPVMGS
QASYGMQQMA GFGRLYPVYP APNVVANTSG SGPKKNGNVS CYNCGVSGHY AQDCKQSSME
ANQQGTYRLR YAPPLPPSND TLDSAD
