ZCHC2_RAT
ID ZCHC2_RAT Reviewed; 1168 AA.
AC Q498S6;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Zinc finger CCHC domain-containing protein 2;
GN Name=Zcchc2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 219-1168 (ISOFORM 2).
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q498S6-1; Sequence=Displayed;
CC Name=2; Synonyms=Tnfrsf11a;
CC IsoId=Q498S6-2; Sequence=VSP_032981, VSP_032982, VSP_032983;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI00091.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AABR03084820; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC100090; AAI00091.1; ALT_INIT; mRNA.
DR RefSeq; NP_001257971.1; NM_001271042.1. [Q498S6-2]
DR RefSeq; XP_006249687.1; XM_006249625.3. [Q498S6-1]
DR RefSeq; XP_006249688.1; XM_006249626.3. [Q498S6-1]
DR AlphaFoldDB; Q498S6; -.
DR SMR; Q498S6; -.
DR STRING; 10116.ENSRNOP00000003870; -.
DR iPTMnet; Q498S6; -.
DR PhosphoSitePlus; Q498S6; -.
DR PaxDb; Q498S6; -.
DR GeneID; 304695; -.
DR KEGG; rno:304695; -.
DR UCSC; RGD:1310626; rat. [Q498S6-1]
DR CTD; 54877; -.
DR RGD; 1310626; Zcchc2.
DR VEuPathDB; HostDB:ENSRNOG00000002882; -.
DR eggNOG; KOG3791; Eukaryota.
DR eggNOG; KOG4400; Eukaryota.
DR InParanoid; Q498S6; -.
DR PhylomeDB; Q498S6; -.
DR TreeFam; TF335574; -.
DR PRO; PR:Q498S6; -.
DR Proteomes; UP000002494; Chromosome 13.
DR Bgee; ENSRNOG00000002882; Expressed in testis and 18 other tissues.
DR ExpressionAtlas; Q498S6; baseline and differential.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.1520.10; -; 1.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR042793; ZCCHC2.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR46939; PTHR46939; 1.
DR Pfam; PF00098; zf-CCHC; 1.
DR SMART; SM00343; ZnF_C2HC; 1.
DR SUPFAM; SSF57756; SSF57756; 1.
DR SUPFAM; SSF64268; SSF64268; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..1168
FT /note="Zinc finger CCHC domain-containing protein 2"
FT /id="PRO_0000329414"
FT ZN_FING 1121..1138
FT /note="CCHC-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT REGION 1..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 561..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 932..978
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..43
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..69
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..589
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..658
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..693
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 932..950
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 951..965
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 466..493
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032981"
FT VAR_SEQ 512
FT /note="N -> K (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032982"
FT VAR_SEQ 513..1168
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032983"
SQ SEQUENCE 1168 AA; 124732 MW; 2073BF76D9403922 CRC64;
MLRMKLPPKS THPSEPPPDA EEPEADARPG AKAPPRRRRD CRPPPPPPTG LPRGPPPPPP
SPPRGLEPPV ASGPTAGAGM PGGGGHAAAL REQERVYEWF GLVLGSAQRL EFLCGLLDLC
NPLELRFLGS CLEDLARKDY HYLRDSEAKA NGLSDPGSLA DFREPAVRSR LIVYLALLGS
ENREAAGRLH RLLPQVDAVL RSLRATRVEG SRGSVEDEPG GDDEQDAEKD GPGPEGGGCA
KLGTGGGLGF RAQEELLLLF TMASLHPAFS FHQRVTLREH LERLRSALRV EPEDAEVEPS
NFAGSRAQND SACGDYIQSN ETGLVEQAQI PQDGLTVAPH RAQREAVHIE KIMLKGVQRR
RADKYWEYTF KVNWSDLSVT TVTKTHQELQ EFLLKLPKEF SSESFDKTIL KALNQGSLRR
EERRHPDLEP ILRQLFSTSP QAFLQSHKVR SFFRSISSES QHSFNNLQSS LKTSKILEHL
KEDSSEASSQ EEDVLQHTII HKKHAGKSPA GNVATSCALL EGLTMQYAEQ NGVVDWRNQG
CAAIQHSEHC VSSADQLSAE KRSLSSVNKK KGKPQVEKEK IKKTENRLSS RINGIRLSAP
QHAHGSTVKD MNLDVGSGHD TCGETSSESY SSPSSPRHDG RESLESEEEK DRDTDSNSED
SGNPSSARFA GHGSVTQTVS VQPPADTVSL GTENGNLLEA PLTSHKYPHI PFMPTLPCVM
HNGAQKSEVV IPSPKSADGK AVGVLVPNPV AISTMMESTN AAPVGILGPA ASGESEKHLE
LLASPLPIPS PFLPHSSAPA LQLTLQSLKL QPPQGASENC PVNIPQQAAT RLSIGSPNTA
LIPVHNPGAF PGSPVAATDP ITKSASQVVG LNQMVPQIEG NTGTVPQPNN VKVVLPAAGL
SAAQPPASYT FPGSPLAASV LPTQNSTVLN TATSAQPAST GISPAQSTVP PAVPTHTPGP
APSPSPALTH STAQSDSTSY ISAVGNTNAN STIVPPQPLG PCGSCGRRCS CGTNGNLQLN
SYYYPNPMPG PMYRLPSFFT LPSICNGSYL NQAHQSNGNQ LPFFLPQTPY ANGLVHDPVM
GSQASYGMQQ MAGFGRLYPV YPAPNVVANT SGSGPKKNGS VSCYNCGVSG HYAQDCKQSS
MEANQQGTYR LRYAPPLPPS NDTLDSAD
