ID   ZCHC8_CHICK             Reviewed;         613 AA.
AC   Q5F3D1;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Zinc finger CCHC domain-containing protein 8;
DE   AltName: Full=TRAMP-like complex RNA-binding factor ZCCHC8;
GN   Name=ZCCHC8; ORFNames=RCJMB04_21c10;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Scaffolding subunit of the trimeric nuclear exosome targeting
CC       (NEXT) complex that is involved in the surveillance and turnover of
CC       aberrant transcripts and non-coding RNAs. NEXT functions as an RNA
CC       exosome cofactor that directs a subset of non-coding short-lived RNAs
CC       for exosomal degradation. May be involved in pre-mRNA splicing. It is
CC       required for 3'-end maturation of telomerase RNA component (TERC), TERC
CC       3'-end targeting to the nuclear RNA exosome, and for telomerase
CC       function. {ECO:0000250|UniProtKB:Q6NZY4}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
CC       {ECO:0000250|UniProtKB:Q6NZY4}. Note=Excluded from nucleolus.
CC       {ECO:0000250|UniProtKB:Q6NZY4}.
CC   -!- SIMILARITY: Belongs to the ZCCHC8 family. {ECO:0000305}.
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DR   EMBL; AJ851719; CAH65353.1; -; mRNA.
DR   AlphaFoldDB; Q5F3D1; -.
DR   SMR; Q5F3D1; -.
DR   STRING; 9031.ENSGALP00000007133; -.
DR   PaxDb; Q5F3D1; -.
DR   VEuPathDB; HostDB:geneid_416862; -.
DR   eggNOG; KOG2673; Eukaryota.
DR   InParanoid; Q5F3D1; -.
DR   OrthoDB; 338817at2759; -.
DR   PhylomeDB; Q5F3D1; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0034470; P:ncRNA processing; ISS:UniProtKB.
DR   InterPro; IPR006568; PSP_pro-rich.
DR   InterPro; IPR001878; Znf_CCHC.
DR   InterPro; IPR036875; Znf_CCHC_sf.
DR   Pfam; PF04046; PSP; 1.
DR   Pfam; PF00098; zf-CCHC; 1.
DR   SMART; SM00581; PSP; 1.
DR   SMART; SM00343; ZnF_C2HC; 1.
DR   SUPFAM; SSF57756; SSF57756; 1.
DR   PROSITE; PS50158; ZF_CCHC; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Metal-binding; Nucleus; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..613
FT                   /note="Zinc finger CCHC domain-containing protein 8"
FT                   /id="PRO_0000150963"
FT   ZN_FING         126..143
FT                   /note="CCHC-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT   REGION          304..330
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          344..417
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          448..473
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          494..546
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          431..451
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        304..318
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        359..399
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        400..417
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        494..534
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   613 AA;  68468 MW;  1569A71B8CDE487E CRC64;
     MVISKQYHQE IEDFVFNLVH KYEDQQRDEQ EKTHFSLKPQ PSSVVLEEDY KTASSNSVKK
     IKEAFSVVGS VLYFTNFCLD KLGQPILNEN PQLTEGWEIP KYQQVFSQIL SLDGQEIQVK
     PKRPKSHCFN CGSEEHQIKD CPKPRNAARI SEKRKEFMEA YGEASNQNFQ QRYHAEEVEE
     RFGKFKPGVI SGELQDALGV TAKSLPPFIY RMRQLGYPPG WLKEAEMEHS GLALYDGKDD
     NETEDEGYLQ PKHVTYDVSK LINYPGFNIS TPSGIPDEWQ IFGSIPMQPS QQKDVFAHYL
     SNFHAPSSKS SNKRTAPQPS SHHSKRPKDD LEVAVADMDI DSDVEVSQRS QTTNSFQFQP
     PLPPGPPVIS TPPPLPQGTP PLTPRSLTPT QPSTPTHPPL PNTVSSLNPS SDVSQPKIVD
     STMDEDTLTL EELEEQQRLI WAALEQAEST NSDSDIPVDT PLTGNSVTSS PSRNEVDVVA
     EVRSDKMVTL ETKFSSISEQ VPENEHSLTS PNPDNSSLNL KEIPDNSDSE GLLDNTVPAP
     NHEVNDGESI VDNKVVTSTE SSAKNSNPVP DMSKFAVGIA PFEFENMTES TGTYLRIRSV
     LKNSPRNQQK KKT