ZCHC9_HUMAN
ID ZCHC9_HUMAN Reviewed; 271 AA.
AC Q8N567; B2RAE7; Q9H027;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Zinc finger CCHC domain-containing protein 9;
GN Name=ZCCHC9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pericardium;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-15.
RC TISSUE=Melanoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=18721783; DOI=10.1016/s1673-8527(08)60064-8;
RA Zhou A., Zhou J., Yang L., Liu M., Li H., Xu S., Han M., Zhang J.;
RT "A nuclear localized protein ZCCHC9 is expressed in cerebral cortex and
RT suppresses the MAPK signal pathway.";
RL J. Genet. Genomics 35:467-472(2008).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: May down-regulate transcription mediated by NF-kappa-B and
CC the serum response element. {ECO:0000269|PubMed:18721783}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:18721783}.
CC Nucleus {ECO:0000269|PubMed:18721783}. Note=Expressed throughout the
CC nucleus and concentrated mainly in the nucleolus.
CC {ECO:0000269|PubMed:18721783}.
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DR EMBL; AK314160; BAG36844.1; -; mRNA.
DR EMBL; AL512712; CAC21654.1; -; mRNA.
DR EMBL; CH471084; EAW95870.1; -; Genomic_DNA.
DR EMBL; BC032736; AAH32736.1; -; mRNA.
DR CCDS; CCDS4054.1; -.
DR RefSeq; NP_001124507.1; NM_001131035.1.
DR RefSeq; NP_001124508.1; NM_001131036.1.
DR RefSeq; NP_115656.1; NM_032280.2.
DR AlphaFoldDB; Q8N567; -.
DR BMRB; Q8N567; -.
DR BioGRID; 123971; 101.
DR IntAct; Q8N567; 27.
DR STRING; 9606.ENSP00000254037; -.
DR iPTMnet; Q8N567; -.
DR PhosphoSitePlus; Q8N567; -.
DR BioMuta; ZCCHC9; -.
DR DMDM; 116242852; -.
DR EPD; Q8N567; -.
DR jPOST; Q8N567; -.
DR MassIVE; Q8N567; -.
DR MaxQB; Q8N567; -.
DR PaxDb; Q8N567; -.
DR PeptideAtlas; Q8N567; -.
DR PRIDE; Q8N567; -.
DR ProteomicsDB; 72007; -.
DR Antibodypedia; 24688; 40 antibodies from 14 providers.
DR DNASU; 84240; -.
DR Ensembl; ENST00000254037.6; ENSP00000254037.2; ENSG00000131732.12.
DR Ensembl; ENST00000380199.9; ENSP00000369546.5; ENSG00000131732.12.
DR Ensembl; ENST00000407610.8; ENSP00000385047.3; ENSG00000131732.12.
DR Ensembl; ENST00000438268.2; ENSP00000412637.2; ENSG00000131732.12.
DR GeneID; 84240; -.
DR KEGG; hsa:84240; -.
DR MANE-Select; ENST00000407610.8; ENSP00000385047.3; NM_001131035.2; NP_001124507.1.
DR UCSC; uc003khi.4; human.
DR CTD; 84240; -.
DR DisGeNET; 84240; -.
DR GeneCards; ZCCHC9; -.
DR HGNC; HGNC:25424; ZCCHC9.
DR HPA; ENSG00000131732; Low tissue specificity.
DR neXtProt; NX_Q8N567; -.
DR OpenTargets; ENSG00000131732; -.
DR PharmGKB; PA134931870; -.
DR VEuPathDB; HostDB:ENSG00000131732; -.
DR eggNOG; KOG4400; Eukaryota.
DR GeneTree; ENSGT00950000183041; -.
DR HOGENOM; CLU_054987_1_0_1; -.
DR InParanoid; Q8N567; -.
DR OMA; MLCFNCR; -.
DR OrthoDB; 1535084at2759; -.
DR PhylomeDB; Q8N567; -.
DR TreeFam; TF352294; -.
DR PathwayCommons; Q8N567; -.
DR SignaLink; Q8N567; -.
DR BioGRID-ORCS; 84240; 616 hits in 1076 CRISPR screens.
DR GenomeRNAi; 84240; -.
DR Pharos; Q8N567; Tdark.
DR PRO; PR:Q8N567; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q8N567; protein.
DR Bgee; ENSG00000131732; Expressed in sperm and 174 other tissues.
DR ExpressionAtlas; Q8N567; baseline and differential.
DR Genevisible; Q8N567; HS.
DR GO; GO:0005730; C:nucleolus; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR042246; ZCCHC9.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR46242; PTHR46242; 1.
DR Pfam; PF00098; zf-CCHC; 2.
DR SMART; SM00343; ZnF_C2HC; 4.
DR SUPFAM; SSF57756; SSF57756; 2.
DR PROSITE; PS50158; ZF_CCHC; 2.
PE 1: Evidence at protein level;
KW Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW Transcription; Zinc; Zinc-finger.
FT CHAIN 1..271
FT /note="Zinc finger CCHC domain-containing protein 9"
FT /id="PRO_0000150965"
FT ZN_FING 128..145
FT /note="CCHC-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT ZN_FING 155..172
FT /note="CCHC-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT ZN_FING 184..201
FT /note="CCHC-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT ZN_FING 211..228
FT /note="CCHC-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 48
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VARIANT 15
FT /note="P -> A (in dbSNP:rs16878594)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_028164"
SQ SEQUENCE 271 AA; 30477 MW; D68EDABE8B9D0F3D CRC64;
MTRWARVSTT YNKRPLPATS WEDMKKGSFE GTSQNLPKRK QLEANRLSLK NDAPQAKHKK
NKKKKEYLNE DVNGFMEYLR QNSQMVHNGQ IIATDSEEVR EEIAVALKKD SRREGRRLKR
QAAKKNAMVC FHCRKPGHGI ADCPAALENQ DMGTGICYRC GSTEHEITKC KAKVDPALGE
FPFAKCFVCG EMGHLSRSCP DNPKGLYADG GGCKLCGSVE HLKKDCPESQ NSERMVTVGR
WAKGMSADYE EILDVPKPQK PKTKIPKVVN F
