ZCHC9_MOUSE
ID ZCHC9_MOUSE Reviewed; 271 AA.
AC Q8R1J3; E9QQ14; Q921T6;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-SEP-2015, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Zinc finger CCHC domain-containing protein 9;
GN Name=Zcchc9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=18721783; DOI=10.1016/s1673-8527(08)60064-8;
RA Zhou A., Zhou J., Yang L., Liu M., Li H., Xu S., Han M., Zhang J.;
RT "A nuclear localized protein ZCCHC9 is expressed in cerebral cortex and
RT suppresses the MAPK signal pathway.";
RL J. Genet. Genomics 35:467-472(2008).
CC -!- FUNCTION: May down-regulate transcription mediated by NF-kappa-B and
CC the serum response element. {ECO:0000250|UniProtKB:Q8N567}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:Q8N567}. Nucleus {ECO:0000250|UniProtKB:Q8N567}.
CC Note=Expressed throughout the nucleus and concentrated mainly in the
CC nucleolus. {ECO:0000250|UniProtKB:Q8N567}.
CC -!- TISSUE SPECIFICITY: Detected in brain cortex and in testis.
CC {ECO:0000269|PubMed:18721783}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BC010687; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC154413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC010687; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC024496; AAH24496.1; -; mRNA.
DR CCDS; CCDS36742.1; -.
DR RefSeq; NP_663428.2; NM_145453.2.
DR AlphaFoldDB; Q8R1J3; -.
DR BioGRID; 213219; 1.
DR IntAct; Q8R1J3; 1.
DR STRING; 10090.ENSMUSP00000022121; -.
DR iPTMnet; Q8R1J3; -.
DR PhosphoSitePlus; Q8R1J3; -.
DR EPD; Q8R1J3; -.
DR MaxQB; Q8R1J3; -.
DR PaxDb; Q8R1J3; -.
DR PRIDE; Q8R1J3; -.
DR ProteomicsDB; 302118; -.
DR Antibodypedia; 24688; 40 antibodies from 14 providers.
DR DNASU; 69085; -.
DR Ensembl; ENSMUST00000022121; ENSMUSP00000022121; ENSMUSG00000021621.
DR GeneID; 69085; -.
DR KEGG; mmu:69085; -.
DR UCSC; uc007rkb.1; mouse.
DR CTD; 84240; -.
DR MGI; MGI:1916335; Zcchc9.
DR VEuPathDB; HostDB:ENSMUSG00000021621; -.
DR eggNOG; KOG4400; Eukaryota.
DR GeneTree; ENSGT00950000183041; -.
DR InParanoid; Q8R1J3; -.
DR OMA; MLCFNCR; -.
DR OrthoDB; 1535084at2759; -.
DR PhylomeDB; Q8R1J3; -.
DR TreeFam; TF352294; -.
DR BioGRID-ORCS; 69085; 23 hits in 73 CRISPR screens.
DR ChiTaRS; Zcchc9; mouse.
DR PRO; PR:Q8R1J3; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q8R1J3; protein.
DR Bgee; ENSMUSG00000021621; Expressed in ascending aorta and 246 other tissues.
DR ExpressionAtlas; Q8R1J3; baseline and differential.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR042246; ZCCHC9.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR46242; PTHR46242; 1.
DR Pfam; PF00098; zf-CCHC; 2.
DR SMART; SM00343; ZnF_C2HC; 4.
DR SUPFAM; SSF57756; SSF57756; 2.
DR PROSITE; PS50158; ZF_CCHC; 2.
PE 2: Evidence at transcript level;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Zinc;
KW Zinc-finger.
FT CHAIN 1..271
FT /note="Zinc finger CCHC domain-containing protein 9"
FT /id="PRO_0000150966"
FT ZN_FING 128..145
FT /note="CCHC-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT ZN_FING 155..172
FT /note="CCHC-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT ZN_FING 184..201
FT /note="CCHC-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT ZN_FING 211..228
FT /note="CCHC-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 271
FT /note="F -> FLY (in Ref. 2; AAH24496)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 271 AA; 30488 MW; 05954324A357A9D5 CRC64;
MTRWARVTTS NSKRPLSATS WEDMKKGSVE RADQSLPNRK QCQSSRLPLR NDSPQAKRKK
NKKKKEYLNE DVNGFMEYLK QNSQVLHNGQ LIAADSQEVR EEIAVALKKD SRREGRRLKR
QAAKKNAMVC FHCRQPGHGI ADCPAVLESQ DMGTGICYRC GSTEHEMSKC RANVDPALGE
FPFAKCFVCG EMGHLSRSCP DNTKGVYADG GSCKLCGSVE HFKKDCRENQ NSDRIITVGR
WAKGMSADYE DVLDVPKLQK PKTKVPKVVN F
