ZCRB1_DANRE
ID ZCRB1_DANRE Reviewed; 218 AA.
AC Q5SP50; Q567W3;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Zinc finger CCHC-type and RNA-binding motif-containing protein 1;
DE AltName: Full=U11/U12 small nuclear ribonucleoprotein 31 kDa protein;
DE Short=U11/U12 snRNP 31 kDa protein;
GN Name=zcrb1; ORFNames=si:ch211-155a11.4, zgc:110711;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Component of the U11/U12 snRNPs that are part of the U12-type
CC spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH92992.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AL929504; CAI11642.1; -; Genomic_DNA.
DR EMBL; BC092992; AAH92992.1; ALT_FRAME; mRNA.
DR RefSeq; NP_001017589.2; NM_001017589.2.
DR AlphaFoldDB; Q5SP50; -.
DR SMR; Q5SP50; -.
DR STRING; 7955.ENSDARP00000067173; -.
DR PaxDb; Q5SP50; -.
DR PRIDE; Q5SP50; -.
DR Ensembl; ENSDART00000067172; ENSDARP00000067171; ENSDARG00000045691.
DR Ensembl; ENSDART00000067174; ENSDARP00000067173; ENSDARG00000045691.
DR GeneID; 550251; -.
DR KEGG; dre:550251; -.
DR CTD; 85437; -.
DR ZFIN; ZDB-GENE-041210-114; zcrb1.
DR eggNOG; KOG0118; Eukaryota.
DR GeneTree; ENSGT00730000111061; -.
DR HOGENOM; CLU_059455_1_0_1; -.
DR InParanoid; Q5SP50; -.
DR OMA; RXVTIMK; -.
DR OrthoDB; 1422822at2759; -.
DR PhylomeDB; Q5SP50; -.
DR TreeFam; TF106263; -.
DR Reactome; R-DRE-72165; mRNA Splicing - Minor Pathway.
DR PRO; PR:Q5SP50; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 4.
DR Bgee; ENSDARG00000045691; Expressed in early embryo and 21 other tissues.
DR ExpressionAtlas; Q5SP50; baseline and differential.
DR GO; GO:0005689; C:U12-type spliceosomal complex; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR CDD; cd12393; RRM_ZCRB1; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR044598; ZCRB1.
DR InterPro; IPR034219; ZCRB1_RRM.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR46259; PTHR46259; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF00098; zf-CCHC; 1.
DR SMART; SM00360; RRM; 1.
DR SMART; SM00343; ZnF_C2HC; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR SUPFAM; SSF57756; SSF57756; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Metal-binding; mRNA processing; mRNA splicing; Nucleus;
KW Reference proteome; RNA-binding; Spliceosome; Zinc; Zinc-finger.
FT CHAIN 1..218
FT /note="Zinc finger CCHC-type and RNA-binding motif-
FT containing protein 1"
FT /id="PRO_0000252376"
FT DOMAIN 10..88
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT ZN_FING 105..122
FT /note="CCHC-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT REGION 122..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 161..196
FT /evidence="ECO:0000255"
FT COMPBIAS 174..218
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 218 AA; 24589 MW; 722864280460B989 CRC64;
MSGGLAPSKS TVYVSNIPFS LTNSDMHKLC SKYGKVVKVT IVKDKHTRMS KGVAFVLFLD
RESAYNCSRS LNNKQLFGRM VKASIAIDNG RAAEFIRKRN YTDKSKCYEC GEEGHLSYAC
PKNLLGEREP PPKKEKKKKK KVQQPEEVEP EDSEEEGEDP ALDSLSQAIA FQQARIEEEE
KRRKQAAEDA SQASTSEDTH KPRIKKSAYF SDEEELSD
