ID   ZCRB1_RAT               Reviewed;         217 AA.
AC   Q499V6;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Zinc finger CCHC-type and RNA-binding motif-containing protein 1;
DE   AltName: Full=U11/U12 small nuclear ribonucleoprotein 31 kDa protein;
DE            Short=U11/U12 snRNP 31 kDa protein;
GN   Name=Zcrb1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBUNIT: Component of the U11/U12 snRNPs that are part of the U12-type
CC       spliceosome. Interacts with ZRSR1 (By similarity). {ECO:0000250,
CC       ECO:0000250|UniProtKB:Q9CZ96}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}.
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DR   EMBL; BC099747; AAH99747.1; -; mRNA.
DR   RefSeq; NP_001030112.1; NM_001034940.1.
DR   AlphaFoldDB; Q499V6; -.
DR   SMR; Q499V6; -.
DR   STRING; 10116.ENSRNOP00000006780; -.
DR   iPTMnet; Q499V6; -.
DR   PhosphoSitePlus; Q499V6; -.
DR   PaxDb; Q499V6; -.
DR   PRIDE; Q499V6; -.
DR   GeneID; 362990; -.
DR   KEGG; rno:362990; -.
DR   CTD; 85437; -.
DR   RGD; 1309851; Zcrb1.
DR   VEuPathDB; HostDB:ENSRNOG00000004996; -.
DR   eggNOG; KOG0118; Eukaryota.
DR   HOGENOM; CLU_059455_1_0_1; -.
DR   InParanoid; Q499V6; -.
DR   OMA; RXVTIMK; -.
DR   OrthoDB; 1422822at2759; -.
DR   PhylomeDB; Q499V6; -.
DR   TreeFam; TF106263; -.
DR   Reactome; R-RNO-72165; mRNA Splicing - Minor Pathway.
DR   PRO; PR:Q499V6; -.
DR   Proteomes; UP000002494; Chromosome 7.
DR   Bgee; ENSRNOG00000004996; Expressed in quadriceps femoris and 19 other tissues.
DR   Genevisible; Q499V6; RN.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005689; C:U12-type spliceosomal complex; ISO:RGD.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   CDD; cd12393; RRM_ZCRB1; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR003954; RRM_dom_euk.
DR   InterPro; IPR044598; ZCRB1.
DR   InterPro; IPR034219; ZCRB1_RRM.
DR   InterPro; IPR001878; Znf_CCHC.
DR   InterPro; IPR036875; Znf_CCHC_sf.
DR   PANTHER; PTHR46259; PTHR46259; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   Pfam; PF00098; zf-CCHC; 1.
DR   SMART; SM00360; RRM; 1.
DR   SMART; SM00361; RRM_1; 1.
DR   SMART; SM00343; ZnF_C2HC; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   SUPFAM; SSF57756; SSF57756; 1.
DR   PROSITE; PS50102; RRM; 1.
DR   PROSITE; PS50158; ZF_CCHC; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein;
KW   Reference proteome; RNA-binding; Spliceosome; Zinc; Zinc-finger.
FT   CHAIN           1..217
FT                   /note="Zinc finger CCHC-type and RNA-binding motif-
FT                   containing protein 1"
FT                   /id="PRO_0000252375"
FT   DOMAIN          10..88
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   ZN_FING         105..122
FT                   /note="CCHC-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT   REGION          120..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        148..163
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        197..217
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         155
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TBF4"
FT   MOD_RES         210
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TBF4"
FT   MOD_RES         216
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TBF4"
SQ   SEQUENCE   217 AA;  24545 MW;  7397DA5B216E5D06 CRC64;
     MSGGLAPSKS TVYVSNLPFS LTNNDLYRIF SKYGKVVKVT IMKDKDTRKS KGVAFILFLD
     KDSALNCTRA INNKQLFGRV IKASIAIDNG RAAEFIRRRN YFDKSKCYEC GESGHLSYAC
     PKNMLGEREP PKKKEKKKKK KVPEPEEEIE EVEVSEEEGE DPALDSLSQA IAFQQAKIEE
     EQNKWRPSTG GPSTSDDSRR PRIKKSAYFS DEEELSD