CC162_MOUSE
ID CC162_MOUSE Reviewed; 912 AA.
AC Q0VG85; A0A087WRU3; Q3UUY5; Q3V339;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 08-MAR-2011, sequence version 4.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Coiled-coil domain-containing protein 162 {ECO:0000305};
GN Name=Ccdc162 {ECO:0000312|MGI:MGI:1923223};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Liver, and Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 163-912 (ISOFORM 5).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PROTEIN SEQUENCE OF 234-246, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=OF1; TISSUE=Hippocampus;
RA Lubec G., Sunyer B., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=5;
CC IsoId=Q0VG85-5; Sequence=Displayed;
CC Name=2;
CC IsoId=Q0VG85-2; Sequence=VSP_040687, VSP_040690, VSP_040691,
CC VSP_040692;
CC Name=3;
CC IsoId=Q0VG85-3; Sequence=VSP_040688, VSP_040689;
CC Name=4;
CC IsoId=Q0VG85-6; Sequence=VSP_059001;
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DR EMBL; AK050292; BAE20670.1; -; mRNA.
DR EMBL; AK137750; BAE23488.1; -; mRNA.
DR EMBL; AC132290; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC161426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC112401; AAI12402.2; -; mRNA.
DR CCDS; CCDS56700.3; -. [Q0VG85-6]
DR RefSeq; NP_001290398.1; NM_001303469.1.
DR RefSeq; XP_006512962.1; XM_006512899.3.
DR AlphaFoldDB; Q0VG85; -.
DR SMR; Q0VG85; -.
DR STRING; 10090.ENSMUSP00000135966; -.
DR iPTMnet; Q0VG85; -.
DR PhosphoSitePlus; Q0VG85; -.
DR MaxQB; Q0VG85; -.
DR PaxDb; Q0VG85; -.
DR PRIDE; Q0VG85; -.
DR ProteomicsDB; 283709; -. [Q0VG85-5]
DR ProteomicsDB; 283710; -. [Q0VG85-2]
DR ProteomicsDB; 283712; -. [Q0VG85-6]
DR Ensembl; ENSMUST00000019955; ENSMUSP00000019955; ENSMUSG00000075225. [Q0VG85-2]
DR Ensembl; ENSMUST00000189488; ENSMUSP00000140774; ENSMUSG00000075225. [Q0VG85-6]
DR UCSC; uc007exw.2; mouse. [Q0VG85-5]
DR UCSC; uc007exx.1; mouse. [Q0VG85-2]
DR MGI; MGI:1923223; Ccdc162.
DR VEuPathDB; HostDB:ENSMUSG00000075225; -.
DR eggNOG; ENOG502QRID; Eukaryota.
DR GeneTree; ENSGT00940000165946; -.
DR HOGENOM; CLU_007479_0_0_1; -.
DR InParanoid; Q0VG85; -.
DR OMA; YECAILR; -.
DR OrthoDB; 54096at2759; -.
DR PhylomeDB; Q0VG85; -.
DR BioGRID-ORCS; 75973; 1 hit in 54 CRISPR screens.
DR ChiTaRS; Ccdc162; mouse.
DR PRO; PR:Q0VG85; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q0VG85; protein.
DR Bgee; ENSMUSG00000075225; Expressed in animal zygote and 67 other tissues.
DR ExpressionAtlas; Q0VG85; baseline and differential.
DR Genevisible; Q0VG85; MM.
DR InterPro; IPR040401; CCDC162.
DR PANTHER; PTHR33331; PTHR33331; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Direct protein sequencing;
KW Reference proteome.
FT CHAIN 1..912
FT /note="Coiled-coil domain-containing protein 162"
FT /id="PRO_0000307298"
FT COILED 1..35
FT /evidence="ECO:0000255"
FT COILED 220..276
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..707
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_040688"
FT VAR_SEQ 1..519
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_040687"
FT VAR_SEQ 1
FT /note="M -> MDSVYKFSSTERIVLLEKELAVKLSELKTEVEDQGLFPGTGNRIFSS
FT VQIPKDVAHFRREREAALKRTLQVAESKPLVIQADVLKRELESCLRREYTPENLPLLLL
FT QYYTERITQLGQSKYLHVLRWKRLCQTSMAMEELYPLYKKQVDYIMQEFNDSVQRAERL
FT SVARENLLMGKNNRPDLVTQEDLAIYTRWLVCHLHALRTIHHFLQALQYLPISRVLSLA
FT AKQVSGSSEEDGKACVTDLHAASPGPLGPHVSGSGRTDAAFVLPQHVTDRDDLKPQLRR
FT LLSHFHIPDDVQKLSDSAKEMGLFSSVSQNFQSIFMEQQRMWTFPDYEAGRGNVQNPTM
FT SGPTTTLRKRADWIPFVKVKPKCDPWQKKMLTRLKERKRIDELMNLQSQFLKISDPVRV
FT MQVLQDHAAKTVPMASNHPSRPPAQPLHPRNYDQVWKNIYSNPKLYQAENPSDDDFAKP
FT HLSQSSDGSLKQRTETGYNFAVALQLLGLSDGTEPDRNPVLMRGAYLSFLCLRHLHIRE
FT LQRICLGVLNFFRSVERTLTMNTSGLTLVSGTLVPTLGDSSWINMSKGGMGTLQGLGTH
FT HYIHGTPAEHKVHSIQFLEFSEAENQDDFHTTQAGYVHTQDQLGEYVVYDSALQDLKEL
FT ESELLLIASHYIEKEKSHRGECRSEGSQLLGWAHANVDRFAVLYDLWTCETNLLEGKRQ
FT LLDSYFEAYQHTLDPEERFALAQAMTDIMHRRPKFDLSHSYFTKAYRDDCTCLRLHLQL
FT VRGILSHHLEQQRDYVQRLWRGDHPEAPKTFGLPLNVICKQFVSISNSCPASGKVHPLE
FT LHPSLGLAGLIPKALEHLFREARHAHKAASPSSLAQIEICSLQLALDLWLSPVKPEAWY
FT SAQLQRELFSAQVMGDPFLMEEVGLLALRSAVDKGVKQGQDFHTLLLDTFSRLLELLTL
FT RHRLIETSVESAYLAGLYKELALEMGFEESHLHLRPVHFEFASHKDKVDPPPPVFITSL
FT LEDSSRVDRYCPTSLVLAISELDDNQIGKFSFHTKEAILKLFVHSGVENMQVTLACQTA
FT QRNALMVAIQQAFFYHIPGAGSLVDLKETSSDPRHHGGVSPCRRDSRTTNGKECLLLTP
FT TLKTPDTFTHSSGFKTSKRAPEAFVSIQLEKAGLRDLMLNTFLHRKQTMMDQIKSPDDV
FT EKVKKELIVEYCQKLNRRMSHYSLRGQIMAYCNSLRVLLDDFPTIRNTFFMVGQPNEKK
FT GLKDSSGELKADSSRSFQPRPRSLLSADGRVFLNLWFIPHPSEVLFM (in isoform
FT 4)"
FT /id="VSP_059001"
FT VAR_SEQ 620..664
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_040690"
FT VAR_SEQ 708..715
FT /note="LWRQNDTQ -> MKESHIRK (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_040689"
FT VAR_SEQ 786..822
FT /note="MRNRLAQERSVKLDAFQRVQELQSQLYDIQWPSVQMG -> VRAADPDLKGL
FT RSQLSMEQLFPGLSVPLTAFSLLCQF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_040691"
FT VAR_SEQ 823..912
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_040692"
SQ SEQUENCE 912 AA; 104336 MW; 2648B9CF22555833 CRC64;
MFKSLPEEEA FRALTLTLQL VASLHDIVAY TFSFAKLGNC PACFDLPLSP NPLMRDWGGA
EGIGNELQEL QKMIDSLQRP QDPSQVAQAL LLRREVTLLQ FDAAMRHLLR TFLAAGNAPA
YQSVAESACY GLPPLSNALG KSIFSSQLSL PQPLDPWSPQ AFALFPWRAF LEDGGPFPVI
SSVPDTLEYD MQMCLCGLSD CDRRVAHGEL VGVQMLMEDV LLGSCHVIRK ASTEWQAALD
NAQPDWSKLP GLYPNQLESH PKASALLEGQ CDVVMSLSLL KSFLILWKRL EVLKEHWGRF
KLRGQDINSA LLHRQFSELY EAEILYPSMK ALARQMGKED EFEELMLRSQ SILPPKGASE
IEIKTQQLQK LLESLEIHMI QEVLRKVNRE MTLFLSEKSK EESTLPTDRW KHQVMKENFS
VMRPQIVERF VQRLMEDSQD DGPKITFRRE HLEACILSLG CDVMARERSN FETYSMCYEH
ILQHTRQKLS QKEQEVDLLR RSQVPSEDCA GQVAELSHDM IMEITALRAQ LTDLEEENLN
LKIQIRKEVQ EEYRELVQAL FLTCLRIKEK LDENQFNLIQ KVCELIGEVR AEGIANVKQL
KKTWGSARPD EETKENTAKE QLCALEQDHS STLAALLCKA RSLGRWRLAV QQAHLRGQLS
RAEMESILSK KECLRIKLMA EQEAALLHQQ LLAARQALTK AQTDNRKLWR QNDTQAQLLR
ELEHRVTQDS VTRQQLDIIK TSGMEKLLKD VEQKEQKLQL LTEEAERASK RGQLQQKKMD
RDLKQMRNRL AQERSVKLDA FQRVQELQSQ LYDIQWPSVQ MGSPVGLRSQ THCSLSSAST
LSRHPHHHFS KTHFVGSKMT RRIQRPKTVP VKHNRRIEDG SLPSVKENVQ LTTFQAQTAP
SGISFRPESF SS
