ZDBF2_HUMAN
ID ZDBF2_HUMAN Reviewed; 2354 AA.
AC Q9HCK1; Q6ZNP7; Q6ZSN8;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 3.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=DBF4-type zinc finger-containing protein 2;
GN Name=ZDBF2; Synonyms=KIAA1571;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1091 AND 1118-1840.
RC TISSUE=Hippocampus, and Umbilical cord;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 576-2354.
RC TISSUE=Brain;
RX PubMed=10997877; DOI=10.1093/dnares/7.4.271;
RA Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVIII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:273-281(2000).
RN [3]
RP SEQUENCE REVISION.
RA Ohara O., Nagase T., Kikuno R.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-539, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
RT "Global, in vivo, and site-specific phosphorylation dynamics in signaling
RT networks.";
RL Cell 127:635-648(2006).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC85454.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK130893; BAC85454.1; ALT_INIT; mRNA.
DR EMBL; AK127271; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AB046791; BAB13397.2; -; mRNA.
DR CCDS; CCDS46501.1; -.
DR RefSeq; NP_065974.1; NM_020923.2.
DR RefSeq; XP_005246768.1; XM_005246711.3.
DR RefSeq; XP_005246769.1; XM_005246712.4.
DR RefSeq; XP_005246770.1; XM_005246713.3.
DR RefSeq; XP_006712719.1; XM_006712656.3.
DR RefSeq; XP_011509834.1; XM_011511532.2.
DR RefSeq; XP_011509835.1; XM_011511533.2.
DR RefSeq; XP_011509836.1; XM_011511534.2.
DR RefSeq; XP_011509837.1; XM_011511535.2.
DR AlphaFoldDB; Q9HCK1; -.
DR SMR; Q9HCK1; -.
DR BioGRID; 121710; 44.
DR IntAct; Q9HCK1; 17.
DR MINT; Q9HCK1; -.
DR STRING; 9606.ENSP00000363545; -.
DR GlyGen; Q9HCK1; 2 sites, 1 O-linked glycan (2 sites).
DR iPTMnet; Q9HCK1; -.
DR PhosphoSitePlus; Q9HCK1; -.
DR BioMuta; ZDBF2; -.
DR DMDM; 166228734; -.
DR EPD; Q9HCK1; -.
DR jPOST; Q9HCK1; -.
DR MassIVE; Q9HCK1; -.
DR MaxQB; Q9HCK1; -.
DR PaxDb; Q9HCK1; -.
DR PeptideAtlas; Q9HCK1; -.
DR PRIDE; Q9HCK1; -.
DR ProteomicsDB; 81743; -.
DR Antibodypedia; 63267; 14 antibodies from 6 providers.
DR Ensembl; ENST00000374423.9; ENSP00000363545.3; ENSG00000204186.10.
DR Ensembl; ENST00000636761.3; ENSP00000490610.1; ENSG00000283649.4.
DR Ensembl; ENST00000649650.1; ENSP00000497308.1; ENSG00000204186.10.
DR Ensembl; ENST00000649768.1; ENSP00000498089.1; ENSG00000283649.4.
DR GeneID; 57683; -.
DR KEGG; hsa:57683; -.
DR MANE-Select; ENST00000374423.9; ENSP00000363545.3; NM_020923.3; NP_065974.1.
DR UCSC; uc002vbp.4; human.
DR CTD; 57683; -.
DR DisGeNET; 57683; -.
DR GeneCards; ZDBF2; -.
DR HGNC; HGNC:29313; ZDBF2.
DR HPA; ENSG00000204186; Low tissue specificity.
DR neXtProt; NX_Q9HCK1; -.
DR OpenTargets; ENSG00000204186; -.
DR PharmGKB; PA162409574; -.
DR VEuPathDB; HostDB:ENSG00000204186; -.
DR eggNOG; ENOG502RXIX; Eukaryota.
DR GeneTree; ENSGT00440000037606; -.
DR HOGENOM; CLU_230228_0_0_1; -.
DR InParanoid; Q9HCK1; -.
DR OMA; MGFHADA; -.
DR OrthoDB; 87289at2759; -.
DR PhylomeDB; Q9HCK1; -.
DR TreeFam; TF339806; -.
DR PathwayCommons; Q9HCK1; -.
DR SignaLink; Q9HCK1; -.
DR BioGRID-ORCS; 57683; 7 hits in 1071 CRISPR screens.
DR ChiTaRS; ZDBF2; human.
DR GenomeRNAi; 57683; -.
DR Pharos; Q9HCK1; Tdark.
DR PRO; PR:Q9HCK1; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q9HCK1; protein.
DR Bgee; ENSG00000204186; Expressed in adrenal tissue and 99 other tissues.
DR ExpressionAtlas; Q9HCK1; baseline and differential.
DR Genevisible; Q9HCK1; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0043045; P:DNA methylation involved in embryo development; IBA:GO_Central.
DR GO; GO:0071514; P:genomic imprinting; IBA:GO_Central.
DR Gene3D; 6.10.250.3410; -; 1.
DR InterPro; IPR038890; ZDBF2.
DR InterPro; IPR006572; Znf_DBF.
DR InterPro; IPR038545; Znf_DBF_sf.
DR PANTHER; PTHR21639; PTHR21639; 1.
DR Pfam; PF07535; zf-DBF; 1.
DR SMART; SM00586; ZnF_DBF; 1.
DR PROSITE; PS51265; ZF_DBF4; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Metal-binding; Phosphoprotein; Reference proteome; Zinc;
KW Zinc-finger.
FT CHAIN 1..2354
FT /note="DBF4-type zinc finger-containing protein 2"
FT /id="PRO_0000314166"
FT ZN_FING 1..50
FT /note="DBF4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00600"
FT REGION 85..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 493..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 693..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 862..886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1352..1375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1680..1736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1752..1793
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2280..2326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 636..660
FT /evidence="ECO:0000255"
FT COILED 1080..1110
FT /evidence="ECO:0000255"
FT COMPBIAS 85..106
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..127
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..714
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 871..886
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1357..1375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1680..1697
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1699..1713
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1763..1789
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 8
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00600"
FT BINDING 11
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00600"
FT BINDING 21
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00600"
FT BINDING 27
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00600"
FT MOD_RES 539
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17081983"
FT VARIANT 160
FT /note="R -> K (in dbSNP:rs10932150)"
FT /id="VAR_037853"
SQ SEQUENCE 2354 AA; 265618 MW; 4B72E43A76CED774 CRC64;
MQKRQGYCSY CRVQYNNLEQ HLFSAQHRSL TRQSRRQICT SSLMERFLQD VLQHHPYHCQ
ESSSTQDETH VNTGSSSEVV HLDDAFSEEE EEDEDKVEDE DATEERPSEV SEPIEELHSR
PHKSQEGTQE VSVRPSVIQK LEKGQQQPLE FVHKIGASVR KCNLVDIGQA TNNRSNLVRP
PVICNAPASC LPESSNDRPV TANTTSLPPA AHLDSVSKCD PNKVEKYLEQ PDGASRNPVP
SSHVETTSFS YQKHKESNRK SLRMNSDKLV LWKDVKSQGK TLSAGLKFHE RMGTKGSLRV
KSPSKLAVNP NKTDMPSNKG IFEDTIAKNH EEFFSNMDCT QEEKHLVFNK TAFWEQKCSV
SSEMKFDCIS LQSASDQPQE TAQDLSLWKE EQIDQEDNYE SRGSEMSFDC SSSFHSLTDQ
SKVSAKEVNL SKEVRTDVQY KNNKSYVSKI SSDCDDILHL VTNQSQMIVK EISLQNARHI
SLVDQSYESS SSETNFDCDA SPQSTSDYPQ QSVTEVNLPK EVHIGLVDKN YGSSSSEVSA
DSVFPLQSVV DRPPVAVTET KLRKKAHTSL VDNYGSSCSE TSFDCDVSLE SVVDHPQLTV
KGRNLKGRQV HLKHKKRKPS SAKAHLDCDV SLGTVADESQ RAVEKINLLK EKNADLMDMN
CESHGPEMGF QADAQLADQS QVAEIERQKV DVDLENKSVQ SSRSSLSSDS PASLYHSAHD
EPQEALDEVN LKELNIDMEV RSYDCSSSEL TFDSDPPLLS VTEQSHLDAE GKERHIDLED
ESCESDSSEI TFDSDIPLYS VIDQPEVAVY EEETVDLESK SNESCVSEIT FDSDIPLHSG
NDHPEVAVKE VIQKEEYIHL ERKNDEPSGS EISSDSHAPL HSVTNSPEVA VKKLNPQKEE
QVHLENKENE PIDSEVSLDY NIIFHSVTGR SEDPIKEISL HTKEHMYLEN KSVFETSLDS
DVPLQAATHK PEVIVKETWL QREKHAEFQG RSTEFSGSKT SLDSGVPHYS VTEPQVAVNK
INRKKQYVLE NKNDKCSGSE IILDSNVPPQ SMTDQPQLAF LKEKHVNLKD KNSKSGDSKI
TFDSEQLQEA VKKIDQWKEE VIGLKNKINE PSTYKLIHHP DVSVQSVADQ PKVAIKHVNL
GNENHMYLEV KNSQYSCSEM NLDSGFLGQS IVNRPQITIL EQEHIELEGK HNQCCGSEVS
FDSDDPLQSV ADRLRETVKE ISLWKDEEVD TEDRRNEAKG FEIMYDSDVL QPVAGQPEEV
VKEVSLWKEH VDLENKIVKP TDSRINFDSH EPLQSVTNKI PGANKEINLL REEHVCLDDK
GYVPSDSEII YVSNIPLQSV IKQPHILEEE HASLEDKSSN SYSPEESSDS NDSFQAAADE
LQKPVKEINL WKEDHIYLED KSYKLGDFDV SYASHIPVQF VTDQSSVPVK EINLQKKDHN
DLENKNCEVC GSEIKCHSCV HLQSEVDQPQ VSYKEADLQK EEHVVMEEKT DQPSDSEMMY
DSDVPFQIVV NQFPGSVKET HLPKVVLVDL VPGDSDYEVI SDDIPLQLVT DPPQLTVKDI
SCINTECIDI EDKSCDFFGS EVRCNCKAST PSMTNQCKET FKIINRKKDY IILGEPSCQS
CGSEMNFNVD ASDQSMTYES QGPDEKMVKY IDSEDKSCGY NGSKGKFNLE DTSHRTTHRL
QKAHKEASLR KDPRNAGLKG KSCQSSASAV DFGASSKSAL HRRADKKKRS KLKHRDLEVS
CEPDGFEMNF QCAPPLPSDT DQPQETVKKR HPCKKVSSDL KEKNHDSQSS SVLKVDSVRN
LKKAKDVIED NPDEPVLEAL PHVPPSFVGK TWSQIMREDD IKINALVKEF REGRFHCYFD
DDCETKKVSS KGKKKVTWAD LQGKEDTAPT QAVSESDDIV CGISDIDDLS VALDKPCHRH
PPAERPPKQK GRVASQCQTA KISHSTQTSC KNYPVMKRKI IRQEEDPPKS KCSRLQDDRK
TKKKVKIGTV EFPASCTKVL KPMQPKALVC VLSSLNIKLK EGEGLPFPKM RHHSWDNDIR
FICKYKRNIF DYYEPLIKQI VISPPLSVIV PEFERRNWVK IHFNRSNQNS SAGDNDADGQ
GSASAPLMAV PARYGFNSHQ GTSDSSLFLE ESKVLHAREL PKKRNFQLTF LNHDVVKISP
KSVRNKLLES QSKKKIHGKR VTTSSNKLGF PKKVYKPIIL QQKPRKASEK QSIWIRTKPS
DIIRKYISKY SVFLRHRYQS RSAFLGRYLK KKKSVVSRLK KAKRTAKVLL NSSVPPAGAE
ELSSAMANPP PKRPVRASCR VARRRKKTDE SYHGRQKGPS TPVRAYDLRS SSCLQQRERM
MTRLANKLRG NEVK
