ZDBF2_MOUSE
ID ZDBF2_MOUSE Reviewed; 2493 AA.
AC Q5SS00; Q3V0Y4; Q9CUN4;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=DBF4-type zinc finger-containing protein 2 homolog;
GN Name=Zdbf2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-253.
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- CAUTION: Compared to its human ortholog it has lost the N-terminal
CC DBF4-type zinc finger. {ECO:0000305}.
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DR EMBL; AL669947; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK015271; BAB29774.1; -; mRNA.
DR EMBL; AK132808; BAE21369.1; -; mRNA.
DR CCDS; CCDS48278.1; -.
DR RefSeq; NP_001254801.1; NM_001267872.1.
DR RefSeq; NP_082949.1; NM_028673.1.
DR AlphaFoldDB; Q5SS00; -.
DR BioGRID; 216330; 2.
DR STRING; 10090.ENSMUSP00000109767; -.
DR iPTMnet; Q5SS00; -.
DR PhosphoSitePlus; Q5SS00; -.
DR MaxQB; Q5SS00; -.
DR PaxDb; Q5SS00; -.
DR PeptideAtlas; Q5SS00; -.
DR PRIDE; Q5SS00; -.
DR ProteomicsDB; 298510; -.
DR Antibodypedia; 63267; 14 antibodies from 6 providers.
DR Ensembl; ENSMUST00000029025; ENSMUSP00000029025; ENSMUSG00000027520.
DR Ensembl; ENSMUST00000114132; ENSMUSP00000109767; ENSMUSG00000027520.
DR GeneID; 73884; -.
DR KEGG; mmu:73884; -.
DR UCSC; uc007bgb.2; mouse.
DR CTD; 57683; -.
DR MGI; MGI:1921134; Zdbf2.
DR VEuPathDB; HostDB:ENSMUSG00000027520; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00440000037606; -.
DR HOGENOM; CLU_230228_0_0_1; -.
DR InParanoid; Q5SS00; -.
DR PhylomeDB; Q5SS00; -.
DR TreeFam; TF339806; -.
DR BioGRID-ORCS; 73884; 1 hit in 70 CRISPR screens.
DR ChiTaRS; Zdbf2; mouse.
DR PRO; PR:Q5SS00; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q5SS00; protein.
DR Bgee; ENSMUSG00000027520; Expressed in superior cervical ganglion and 173 other tissues.
DR ExpressionAtlas; Q5SS00; baseline and differential.
DR Genevisible; Q5SS00; MM.
DR GO; GO:0043045; P:DNA methylation involved in embryo development; IMP:MGI.
DR GO; GO:0071514; P:genomic imprinting; IMP:MGI.
DR InterPro; IPR038890; ZDBF2.
DR PANTHER; PTHR21639; PTHR21639; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..2493
FT /note="DBF4-type zinc finger-containing protein 2 homolog"
FT /id="PRO_0000314167"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 54..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 445..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 961..1018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1078..1099
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1230..1267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1814..1836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1931..1967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1108..1132
FT /evidence="ECO:0000255"
FT COILED 2211..2237
FT /evidence="ECO:0000255"
FT COMPBIAS 96..120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..327
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..410
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 968..983
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 988..1006
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1237..1257
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1936..1965
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2493 AA; 273748 MW; E26EC899B797D022 CRC64;
MEAQSYQEVM KNNGQHLFSS QHRSLTRQSR RRTATNNTLM ERFLQDVLRH HPYNYQDNRS
APNEPEAAAA AAAAADPGSP EVVVVLDDSD EKEDDTADSG AERNSEDSGS VEEIDYRPGT
SQEHAEVAVR PSVIQKLERG QQQSLELAHK VESGVKKVNS VGVVQATTSG KKLVRPPVIC
NAPASSLPSG SFERPVAANS VPRLVLAVAS DSFPACDTEN LETYFDSPDQ GPSNPSSQPK
TKDPKKKLSI NLDKLLAQRN LRAKGASFSP VVRVRELTGS ELCSVRAESS ELEAGTAGNP
RETDTLPEQA REGAIPKRRE ASRSNTVRPQ EETRLVLNKP TLLKQKRSVS SEERFSCGSR
QAVPGPSQAA VRDLSLLEEE VEEEKQEEEE EEEQEEEEEH EEEEEGVDQE DASYESRGSD
MSFDCGSSCQ SLSALSELTA REINVSEETH AYSQPRNETP TVSGATSDNG SSSRQVITQN
IQLISLVDES YESSGSEVNF DGDDSLPSTS HRPPQPVEVV VPLRLVDKSY GSGSSEPCED
SGSSADETPA ASRQQNPVRN THANLVDENY GSSSFSSDSD AALDHPQVPV QEGSPRGRAV
GQGNEEQPSS AEAHPERDGS LETVAHELQR ESQEINLPNQ KNTSLGDMNC ESHGPEVGFH
ADAQLEADQS PVNPEEVDLD LENQSVHSGI SNLSFDSNAS YQSANDQPQG AWGEVNLDEL
NVDMEVKSNG CSSSELTFDS DSPLLSVTER SLLDFEGLNE DDFNLEDENC VSSSSDITFD
SDIPDDSVAD QPQVAVYEEE PVGLENKSNE SCVSGITFDS DIPLHSGNDH PEVAVKEVII
KEDENVHLEG KNDNPSGSEI CLDSNVPLHS VTNSDVAVKK INPPKEDQVQ IEQIEQKENE
PTDSELNLDC NSVNSKPGCS EDPIILRVSE TRLDSHVPFQ SVIRKCEVVV KNVCLQKEKH
AELTSKSTES HSEVSSASTA SHPVTEPYVG KKAKRKTKHL EEVNSDDEYG GSQPTFKFDV
FPRTMTEKPQ PAALKEGHAD PKDKITELRG MAVNVNTADC LDSVLSQPQL ASNENCVELK
DTDGKPSDSK ASADSTGHFH SLPKQEFDVV SKMNEWKKEA KVLEQKISDL IYSKIIHDSN
VSFRSAMDQL ELALKQISLG NNDQVSLEDN SQDTCSETNL DSGFSVQAVV EPPEPEVTVL
EPEHVEQEGR NNVPCDSEVS VDANGSVQLE AGQHSESGEN RSQKDTDDTE GKRDDAQGFG
ITCDSNVPQP LAGHIEVVQD IDHWKDHVDL EDKLGESKNS KVNFHSDEPL QAVTNATQEP
VEEINLPRGR ASPNGNGCEP YGSTIVPVTN VIFCSVIQKP QRLQKKCTSL KENSSNPCPE
VNVDSCDGPE VSVDSNDPCQ SVAGHLQKPD KEMNLKEDHI YLEDKSYKLV DFEPTYDSDD
PVQFVTVPSV EAVSIKEVNL QKENPDDLEN ENFQPCCSEV ACNSAVHLQS EADPPQVACK
EADLDKKALD IEDKGSVTCV PEVVYDSDVS FQIVVNQVQT SDGETDSPQV VFVDVVSSDS
DCDREVISDS NIPLQLEPPQ MTVKETSDIN TDSLGSAANE KYYCKFCGCD YEASQSVTNQ
SKESFKIINR KNDYIILGDS TCPSCGHELN FNVDPSDQPT TCQLQQPDRN FIDPEDKNFG
SKCPKRKLNW EDTAHPVTHQ LQKTGEATSL RKDQKNRFKR DRGWESSSFA GDHAAYAVSV
IRQTALNSCG SELNFQDDTF YHSDIDPPQP KKKGQGKKVT FDLRVTKYEY PPNPMYGEGE
EVAEDDLKEV VVHEASPQGQ APPSIVGKTC PQGREDDVKT NTQACQGYFY SYYDGGSETK
KILLGEEEKT IRSDLNQNTT SIQHVKGKVG DTGDFSVDLG KQSCSLAEGL HQQHGQVTSQ
NQVEVRCGIQ ASSGKKRKIT EQEEDSPKRK CFHHDSQKKK KAQAGITELP EPQTKVLEPV
QPDSLVYIFS SLSMKEDQSL NPPKTKPGSD SDLPHIYSCR EHTSSGPRRK RTVINPPQNL
MVPEVGIDLN RHDPKPNAGD DSAKRQNLVS TSFMAMPKKS VLKFQRTNQS SFLKKSEDVG
ATQVPKDNFQ QTLVNRDGAK KFPKSVKKED LESQNQRKFW KKKMVAANKL CLIKNAYKTM
VLRKKSKLAS EKLAIWIQLK ATDIIRKYVS RCHGLMPRRH LSKTVLIRMQ LRKKKIVARK
IKEAKRAAEA LALKLSRPSC PPRAPCPPRA LCPPRAPCPP RALCPPRAPC PPRALCTPRA
PCPPRALCTP RAPCPPRALC TPRAPCPPRA LRAPCPPRAL CSPRAPCPPR ALCPPRAPCP
PRAPRAPCPP RAPCPPRAPC LPRAPCPPRA PCPPRAPCLP RAPCLPQAPC PPRALCLPRV
SCPPLPLCAP CPPCAPVLPA GAEEQLSTTA GPAELPAHLS NAGGIKRYRK TYFRRRKRLL
PVREYDLRSL SSTTNTDRMV TRLASKSKSN EAK
