ID   CC166_HUMAN             Reviewed;         439 AA.
AC   P0CW27;
DT   21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT   21-SEP-2011, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Coiled-coil domain-containing protein 166;
GN   Name=CCDC166;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA   Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA   Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA   Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA   Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA   Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA   Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA   O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA   Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA   Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA   Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA   Platzer M., Shimizu N., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
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DR   EMBL; AC105219; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS55280.1; -.
DR   RefSeq; NP_001156386.1; NM_001162914.1.
DR   AlphaFoldDB; P0CW27; -.
DR   SMR; P0CW27; -.
DR   STRING; 9606.ENSP00000437468; -.
DR   iPTMnet; P0CW27; -.
DR   PhosphoSitePlus; P0CW27; -.
DR   BioMuta; CCDC166; -.
DR   DMDM; 347602472; -.
DR   MassIVE; P0CW27; -.
DR   PaxDb; P0CW27; -.
DR   PeptideAtlas; P0CW27; -.
DR   PRIDE; P0CW27; -.
DR   Antibodypedia; 63763; 4 antibodies from 4 providers.
DR   DNASU; 100130274; -.
DR   Ensembl; ENST00000533508.2; ENSP00000437315.2; ENSG00000278749.1.
DR   Ensembl; ENST00000542437.1; ENSP00000437468.1; ENSG00000255181.3.
DR   GeneID; 100130274; -.
DR   KEGG; hsa:100130274; -.
DR   MANE-Select; ENST00000542437.1; ENSP00000437468.1; NM_001162914.1; NP_001156386.1.
DR   UCSC; uc011lkr.2; human.
DR   CTD; 100130274; -.
DR   GeneCards; CCDC166; -.
DR   HGNC; HGNC:41910; CCDC166.
DR   HPA; ENSG00000255181; Tissue enriched (testis).
DR   neXtProt; NX_P0CW27; -.
DR   OpenTargets; ENSG00000255181; -.
DR   VEuPathDB; HostDB:ENSG00000255181; -.
DR   eggNOG; ENOG502RXQ4; Eukaryota.
DR   GeneTree; ENSGT00940000154427; -.
DR   HOGENOM; CLU_609628_0_0_1; -.
DR   InParanoid; P0CW27; -.
DR   OMA; QLDACEE; -.
DR   OrthoDB; 997189at2759; -.
DR   PhylomeDB; P0CW27; -.
DR   TreeFam; TF343581; -.
DR   PathwayCommons; P0CW27; -.
DR   BioGRID-ORCS; 100130274; 6 hits in 1005 CRISPR screens.
DR   Pharos; P0CW27; Tdark.
DR   PRO; PR:P0CW27; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; P0CW27; protein.
DR   Bgee; ENSG00000255181; Expressed in left testis and 10 other tissues.
DR   InterPro; IPR029584; CCDC166.
DR   InterPro; IPR032777; DUF4515.
DR   PANTHER; PTHR14845:SF4; PTHR14845:SF4; 1.
DR   Pfam; PF14988; DUF4515; 1.
PE   4: Predicted;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..439
FT                   /note="Coiled-coil domain-containing protein 166"
FT                   /id="PRO_0000412224"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          276..439
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          27..74
FT                   /evidence="ECO:0000255"
FT   COILED          121..213
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        289..317
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        334..405
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   439 AA;  48709 MW;  6394873C2985C8A4 CRC64;
     MAPKKKRGPS AGSQPGGAAA AGAEQPLSER AQYLQREHAL LSEQLDTCEE SVDQVLRENA
     FLDREALRLR EENRLYASYV SARAQRCAKA IVRLDEQNRV DLAQIHWQRA ELASLYHGRE
     DGVRAQLLEM EARAAQMAQQ VQELQPYKVL QLEQLARIRA LERELLHMRV EHTQLLHRVK
     RRFLEDKAAF EREARQRVQS LARRAEREAV RALVAHTQAI KADNGRLRQE LLLLLRRTQL
     LHHTRRQLLE QREQLHREHE DTRDLARVHG WLRRGPGGPP LWERPAFSQP TSRPGSLAAP
     ISPSRAASQT PSVVPSRAAP RASSVVPSRE ASRVPSLVLS SMDSRVPSLA TSKVGSRMPS
     LTASRAGSRA LSLVQSLEGS GISSGSSPRV SSQDTLRSTK SGPKLLSGLS RDRDPALLPP
     QSEDSVNAEA AAEASPGRA