ID   CC167_HUMAN             Reviewed;          97 AA.
AC   Q9P0B6; Q5T7F7; Q9BTQ9;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 2.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Coiled-coil domain-containing protein 167;
GN   Name=CCDC167; Synonyms=C6orf129; ORFNames=HSPC265;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Umbilical cord blood;
RA   Ye M., Zhang Q.-H., Zhou J., Shen Y., Wu X.-Y., Guan Z.Q., Wang L.,
RA   Fan H.-Y., Mao Y.-F., Dai M., Huang Q.-H., Chen S.-J., Chen Z.;
RT   "Human partial CDS from CD34+ stem cells.";
RL   Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex, Lung carcinoma, and Pancreatic carcinoma;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
CC   -!- INTERACTION:
CC       Q9P0B6; Q92624: APPBP2; NbExp=3; IntAct=EBI-9083477, EBI-743771;
CC       Q9P0B6; Q13520: AQP6; NbExp=3; IntAct=EBI-9083477, EBI-13059134;
CC       Q9P0B6; O43315: AQP9; NbExp=3; IntAct=EBI-9083477, EBI-17444777;
CC       Q9P0B6; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-9083477, EBI-11343438;
CC       Q9P0B6; P11912: CD79A; NbExp=3; IntAct=EBI-9083477, EBI-7797864;
CC       Q9P0B6; O00501: CLDN5; NbExp=3; IntAct=EBI-9083477, EBI-18400628;
CC       Q9P0B6; P49238-4: CX3CR1; NbExp=3; IntAct=EBI-9083477, EBI-13049264;
CC       Q9P0B6; Q15125: EBP; NbExp=3; IntAct=EBI-9083477, EBI-3915253;
CC       Q9P0B6; Q9GZR5: ELOVL4; NbExp=3; IntAct=EBI-9083477, EBI-18535450;
CC       Q9P0B6; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-9083477, EBI-781551;
CC       Q9P0B6; Q8TBP5: FAM174A; NbExp=3; IntAct=EBI-9083477, EBI-18636064;
CC       Q9P0B6; Q96KR6: FAM210B; NbExp=3; IntAct=EBI-9083477, EBI-18938272;
CC       Q9P0B6; O15552: FFAR2; NbExp=3; IntAct=EBI-9083477, EBI-2833872;
CC       Q9P0B6; P48165: GJA8; NbExp=3; IntAct=EBI-9083477, EBI-17458373;
CC       Q9P0B6; Q6ZVE7: GOLT1A; NbExp=3; IntAct=EBI-9083477, EBI-17231387;
CC       Q9P0B6; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-9083477, EBI-13345167;
CC       Q9P0B6; O15529: GPR42; NbExp=3; IntAct=EBI-9083477, EBI-18076404;
CC       Q9P0B6; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-9083477, EBI-18053395;
CC       Q9P0B6; Q96HJ5: MS4A3; NbExp=3; IntAct=EBI-9083477, EBI-12806656;
CC       Q9P0B6; P15941-11: MUC1; NbExp=3; IntAct=EBI-9083477, EBI-17263240;
CC       Q9P0B6; Q7RTP0: NIPA1; NbExp=3; IntAct=EBI-9083477, EBI-17702144;
CC       Q9P0B6; P35372-10: OPRM1; NbExp=3; IntAct=EBI-9083477, EBI-12807478;
CC       Q9P0B6; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-9083477, EBI-10192441;
CC       Q9P0B6; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-9083477, EBI-18159983;
CC       Q9P0B6; Q16572: SLC18A3; NbExp=3; IntAct=EBI-9083477, EBI-17598000;
CC       Q9P0B6; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-9083477, EBI-17295964;
CC       Q9P0B6; Q8TBB6: SLC7A14; NbExp=3; IntAct=EBI-9083477, EBI-5235586;
CC       Q9P0B6; Q8N9I0: SYT2; NbExp=3; IntAct=EBI-9083477, EBI-8032987;
CC       Q9P0B6; P25103: TACR1; NbExp=3; IntAct=EBI-9083477, EBI-6655287;
CC       Q9P0B6; Q96MV1: TLCD4; NbExp=3; IntAct=EBI-9083477, EBI-12947623;
CC       Q9P0B6; Q96DZ7: TM4SF19; NbExp=3; IntAct=EBI-9083477, EBI-6448756;
CC       Q9P0B6; Q7Z7N9: TMEM179B; NbExp=3; IntAct=EBI-9083477, EBI-11724423;
CC       Q9P0B6; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-9083477, EBI-10982110;
CC       Q9P0B6; Q9NW97: TMEM51; NbExp=3; IntAct=EBI-9083477, EBI-726044;
CC       Q9P0B6; Q96HE8: TMEM80; NbExp=3; IntAct=EBI-9083477, EBI-11742770;
CC       Q9P0B6; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-9083477, EBI-2548832;
CC       Q9P0B6; Q9Y320: TMX2; NbExp=3; IntAct=EBI-9083477, EBI-6447886;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF28943.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAH03515.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AF161383; AAF28943.1; ALT_INIT; mRNA.
DR   EMBL; AL353597; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471081; EAX03947.1; -; Genomic_DNA.
DR   EMBL; BC003515; AAH03515.1; ALT_INIT; mRNA.
DR   EMBL; BC104835; AAI04836.1; -; mRNA.
DR   EMBL; BC108655; AAI08656.1; -; mRNA.
DR   CCDS; CCDS34441.1; -.
DR   RefSeq; NP_612502.1; NM_138493.2.
DR   AlphaFoldDB; Q9P0B6; -.
DR   SMR; Q9P0B6; -.
DR   BioGRID; 127548; 55.
DR   IntAct; Q9P0B6; 42.
DR   STRING; 9606.ENSP00000362507; -.
DR   iPTMnet; Q9P0B6; -.
DR   PhosphoSitePlus; Q9P0B6; -.
DR   BioMuta; CCDC167; -.
DR   DMDM; 160017504; -.
DR   EPD; Q9P0B6; -.
DR   jPOST; Q9P0B6; -.
DR   MassIVE; Q9P0B6; -.
DR   MaxQB; Q9P0B6; -.
DR   PaxDb; Q9P0B6; -.
DR   PeptideAtlas; Q9P0B6; -.
DR   PRIDE; Q9P0B6; -.
DR   ProteomicsDB; 83547; -.
DR   Antibodypedia; 50913; 51 antibodies from 11 providers.
DR   DNASU; 154467; -.
DR   Ensembl; ENST00000373408.4; ENSP00000362507.3; ENSG00000198937.9.
DR   GeneID; 154467; -.
DR   KEGG; hsa:154467; -.
DR   MANE-Select; ENST00000373408.4; ENSP00000362507.3; NM_138493.3; NP_612502.1.
DR   UCSC; uc003ont.4; human.
DR   CTD; 154467; -.
DR   DisGeNET; 154467; -.
DR   GeneCards; CCDC167; -.
DR   HGNC; HGNC:21239; CCDC167.
DR   HPA; ENSG00000198937; Low tissue specificity.
DR   neXtProt; NX_Q9P0B6; -.
DR   OpenTargets; ENSG00000198937; -.
DR   PharmGKB; PA134900129; -.
DR   VEuPathDB; HostDB:ENSG00000198937; -.
DR   eggNOG; ENOG502SAF4; Eukaryota.
DR   GeneTree; ENSGT00390000010210; -.
DR   HOGENOM; CLU_152032_0_0_1; -.
DR   InParanoid; Q9P0B6; -.
DR   OMA; IYACWTM; -.
DR   OrthoDB; 1588154at2759; -.
DR   PhylomeDB; Q9P0B6; -.
DR   TreeFam; TF336097; -.
DR   PathwayCommons; Q9P0B6; -.
DR   SignaLink; Q9P0B6; -.
DR   BioGRID-ORCS; 154467; 13 hits in 1077 CRISPR screens.
DR   ChiTaRS; CCDC167; human.
DR   GenomeRNAi; 154467; -.
DR   Pharos; Q9P0B6; Tdark.
DR   PRO; PR:Q9P0B6; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q9P0B6; protein.
DR   Bgee; ENSG00000198937; Expressed in ganglionic eminence and 171 other tissues.
DR   Genevisible; Q9P0B6; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR028194; CCDC-167.
DR   PANTHER; PTHR31759; PTHR31759; 1.
DR   Pfam; PF15188; CCDC-167; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..97
FT                   /note="Coiled-coil domain-containing protein 167"
FT                   /id="PRO_0000308550"
FT   TRANSMEM        78..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   COILED          10..79
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   97 AA;  11459 MW;  8B68E89EFEEB782C CRC64;
     MTKKKRENLG VALEIDGLEE KLSQCRRDLE AVNSRLHSRE LSPEARRSLE KEKNSLMNKA
     SNYEKELKFL RQENRKNMLL SVAIFILLTL VYAYWTM