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ZDH21_BOVIN
ID   ZDH21_BOVIN             Reviewed;         265 AA.
AC   A2VDT6;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Palmitoyltransferase ZDHHC21 {ECO:0000305};
DE            EC=2.3.1.225 {ECO:0000250|UniProtKB:Q8IVQ6};
DE   AltName: Full=Zinc finger DHHC domain-containing protein 21 {ECO:0000250|UniProtKB:Q8IVQ6};
GN   Name=ZDHHC21 {ECO:0000250|UniProtKB:Q8IVQ6};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Palmitoyltransferase that catalyzes the addition of palmitate
CC       onto various protein substrates (By similarity). Palmitoylates sex
CC       steroid hormone receptors, including ESR1, PGR and AR, thereby
CC       regulating their targeting to the plasma membrane. This affects rapid
CC       intracellular signaling by sex hormones via ERK and AKT kinases and the
CC       generation of cAMP, but does not affect that mediated by their nuclear
CC       receptor (By similarity). Palmitoylates FYN, regulates its localization
CC       in hair follicles and plays a key role in epidermal homeostasis and
CC       hair follicle differentiation. Through the palmitoylation of PLCB1 and
CC       the regulation of PLCB1 downstream signaling may indirectly regulate
CC       the function of the endothelial barrier and the adhesion of leukocytes
CC       to the endothelium. Has also a palmitoyltransferase activity toward
CC       ADRA1D, positively regulating its activity and expression and may
CC       thereby play a role in vascular contraction. May also palmitoylate eNOS
CC       and LCK (By similarity). {ECO:0000250|UniProtKB:Q8IVQ6,
CC       ECO:0000250|UniProtKB:Q9D270}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC         hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC         COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC         EC=2.3.1.225; Evidence={ECO:0000250|UniProtKB:Q9D270};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684;
CC         Evidence={ECO:0000250|UniProtKB:Q9D270};
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q8IVQ6}; Multi-pass membrane protein
CC       {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane
CC       {ECO:0000250|UniProtKB:Q9D270}; Multi-pass membrane protein
CC       {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q8IVQ6}; Multi-pass
CC       membrane protein {ECO:0000255}.
CC   -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC       {ECO:0000250|UniProtKB:Q8IUH5}.
CC   -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; BC133395; AAI33396.1; -; mRNA.
DR   RefSeq; NP_001075003.1; NM_001081534.1.
DR   RefSeq; XP_005209984.1; XM_005209927.3.
DR   RefSeq; XP_010806101.1; XM_010807799.2.
DR   RefSeq; XP_015327924.1; XM_015472438.1.
DR   AlphaFoldDB; A2VDT6; -.
DR   SMR; A2VDT6; -.
DR   STRING; 9913.ENSBTAP00000008139; -.
DR   PaxDb; A2VDT6; -.
DR   PRIDE; A2VDT6; -.
DR   Ensembl; ENSBTAT00000008139; ENSBTAP00000008139; ENSBTAG00000006197.
DR   Ensembl; ENSBTAT00000076731; ENSBTAP00000064041; ENSBTAG00000006197.
DR   GeneID; 535814; -.
DR   KEGG; bta:535814; -.
DR   CTD; 340481; -.
DR   VEuPathDB; HostDB:ENSBTAG00000006197; -.
DR   VGNC; VGNC:37137; ZDHHC21.
DR   eggNOG; KOG1311; Eukaryota.
DR   GeneTree; ENSGT00940000158006; -.
DR   HOGENOM; CLU_048061_3_0_1; -.
DR   InParanoid; A2VDT6; -.
DR   OMA; GTHWKIL; -.
DR   OrthoDB; 1491968at2759; -.
DR   TreeFam; TF319798; -.
DR   Proteomes; UP000009136; Chromosome 8.
DR   Bgee; ENSBTAG00000006197; Expressed in semen and 103 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0071875; P:adrenergic receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0001942; P:hair follicle development; IEA:Ensembl.
DR   GO; GO:0018230; P:peptidyl-L-cysteine S-palmitoylation; ISS:UniProtKB.
DR   GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; ISS:UniProtKB.
DR   GO; GO:1904997; P:regulation of leukocyte adhesion to arterial endothelial cell; ISS:UniProtKB.
DR   GO; GO:0003056; P:regulation of vascular associated smooth muscle contraction; ISS:UniProtKB.
DR   GO; GO:0048733; P:sebaceous gland development; IEA:Ensembl.
DR   InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR   Pfam; PF01529; DHHC; 1.
DR   PROSITE; PS50216; DHHC; 1.
PE   2: Evidence at transcript level;
KW   Acyltransferase; Cell membrane; Golgi apparatus; Lipoprotein; Membrane;
KW   Palmitate; Reference proteome; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..265
FT                   /note="Palmitoyltransferase ZDHHC21"
FT                   /id="PRO_0000288683"
FT   TOPO_DOM        1..16
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        17..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        38..44
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        66..133
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        155..185
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        207..265
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   DOMAIN          90..140
FT                   /note="DHHC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00067"
FT   ACT_SITE        120
FT                   /note="S-palmitoyl cysteine intermediate"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D270"
SQ   SEQUENCE   265 AA;  31463 MW;  D32AE447AEAEAC0B CRC64;
     MGLRIHFVVD PHGWCCMGLI VFVWLYNFFL IPKIVLFPHY EEGHIPGILI IIFYGIAMFC
     LVALVRASIT DPGRLPENPK IPHGEREFWE LCNKCNLMRP KRSHHCSRCG HCVRRMDHHC
     PWINNCVGED NHWLFLQLCF YTELLTCYAL MFSFCHYYYF LPLKKRNLDL FVVRHELAIM
     RLAAFMGITM LVGITGLFYT QLIGIITDTT SIEKMSNCCE EISRPRKPWQ QTFSEVFGTR
     WKILWFIPFR RRQPLRVPYH FANHV
 
 
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