CC167_MOUSE
ID CC167_MOUSE Reviewed; 97 AA.
AC Q9D162; Q8BQL8; Q8C3L9; Q8R1Y8;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Coiled-coil domain-containing protein 167;
GN Name=Ccdc167;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Kidney, Liver, Pancreas, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9D162-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D162-2; Sequence=VSP_028986;
CC Name=3;
CC IsoId=Q9D162-3; Sequence=VSP_028985;
CC -!- MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH22730.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB23065.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC33728.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK003900; BAB23065.1; ALT_INIT; mRNA.
DR EMBL; AK049389; BAC33728.1; ALT_INIT; mRNA.
DR EMBL; AK085526; BAC39463.1; -; mRNA.
DR EMBL; BC022730; AAH22730.1; ALT_INIT; mRNA.
DR CCDS; CCDS50051.1; -. [Q9D162-1]
DR CCDS; CCDS50052.1; -. [Q9D162-2]
DR RefSeq; NP_001157213.1; NM_001163741.2. [Q9D162-2]
DR RefSeq; NP_081058.1; NM_026782.2. [Q9D162-1]
DR AlphaFoldDB; Q9D162; -.
DR SMR; Q9D162; -.
DR STRING; 10090.ENSMUSP00000116591; -.
DR iPTMnet; Q9D162; -.
DR PhosphoSitePlus; Q9D162; -.
DR EPD; Q9D162; -.
DR MaxQB; Q9D162; -.
DR PaxDb; Q9D162; -.
DR PeptideAtlas; Q9D162; -.
DR PRIDE; Q9D162; -.
DR ProteomicsDB; 281244; -. [Q9D162-1]
DR ProteomicsDB; 281245; -. [Q9D162-2]
DR ProteomicsDB; 281246; -. [Q9D162-3]
DR Antibodypedia; 50913; 51 antibodies from 11 providers.
DR Ensembl; ENSMUST00000123502; ENSMUSP00000119013; ENSMUSG00000024018. [Q9D162-3]
DR Ensembl; ENSMUST00000128751; ENSMUSP00000123612; ENSMUSG00000024018. [Q9D162-1]
DR Ensembl; ENSMUST00000129091; ENSMUSP00000116591; ENSMUSG00000024018. [Q9D162-2]
DR GeneID; 68597; -.
DR KEGG; mmu:68597; -.
DR UCSC; uc008btj.2; mouse. [Q9D162-2]
DR UCSC; uc008btk.2; mouse. [Q9D162-1]
DR CTD; 154467; -.
DR MGI; MGI:1915847; Ccdc167.
DR VEuPathDB; HostDB:ENSMUSG00000024018; -.
DR eggNOG; ENOG502SAF4; Eukaryota.
DR GeneTree; ENSGT00390000010210; -.
DR HOGENOM; CLU_152032_0_0_1; -.
DR InParanoid; Q9D162; -.
DR OMA; IYACWTM; -.
DR OrthoDB; 1588154at2759; -.
DR PhylomeDB; Q9D162; -.
DR TreeFam; TF336097; -.
DR BioGRID-ORCS; 68597; 1 hit in 55 CRISPR screens.
DR ChiTaRS; Ccdc167; mouse.
DR PRO; PR:Q9D162; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q9D162; protein.
DR Bgee; ENSMUSG00000024018; Expressed in dorsal pancreas and 210 other tissues.
DR ExpressionAtlas; Q9D162; baseline and differential.
DR Genevisible; Q9D162; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR028194; CCDC-167.
DR PANTHER; PTHR31759; PTHR31759; 1.
DR Pfam; PF15188; CCDC-167; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..97
FT /note="Coiled-coil domain-containing protein 167"
FT /id="PRO_0000308551"
FT TRANSMEM 78..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT COILED 2..78
FT /evidence="ECO:0000255"
FT VAR_SEQ 46
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028985"
FT VAR_SEQ 97
FT /note="M -> IRYTSFTL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028986"
SQ SEQUENCE 97 AA; 11475 MW; F13EC37EA4025C00 CRC64;
MTKKKRENLG VAQEIDGLEE KLSRCRKDLE AVTSQLYRAE LSPEDRRSLE KEKHTLMNKA
SKYEKELKLL RHENRKNTLL SVAIFTVFAL LYAYWTM
