ZDH24_HUMAN
ID ZDH24_HUMAN Reviewed; 284 AA.
AC Q6UX98; Q6PEW7; Q9BSJ0;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Probable palmitoyltransferase ZDHHC24 {ECO:0000305};
DE EC=2.3.1.225 {ECO:0000305};
DE AltName: Full=Zinc finger DHHC domain-containing protein 24 {ECO:0000312|HGNC:HGNC:27387};
GN Name=ZDHHC24 {ECO:0000312|HGNC:HGNC:27387};
GN ORFNames=UNQ2528/PRO6027 {ECO:0000312|EMBL:AAQ88813.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Choriocarcinoma, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probable palmitoyltransferase that could catalyze the
CC addition of palmitate onto various protein substrates. {ECO:0000305}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC EC=2.3.1.225; Evidence={ECO:0000305};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684;
CC Evidence={ECO:0000305};
CC -!- INTERACTION:
CC Q6UX98; O95994: AGR2; NbExp=3; IntAct=EBI-10254561, EBI-712648;
CC Q6UX98; Q13520: AQP6; NbExp=3; IntAct=EBI-10254561, EBI-13059134;
CC Q6UX98; Q15125: EBP; NbExp=3; IntAct=EBI-10254561, EBI-3915253;
CC Q6UX98; Q8NBQ5: HSD17B11; NbExp=3; IntAct=EBI-10254561, EBI-1052304;
CC Q6UX98; P38484: IFNGR2; NbExp=3; IntAct=EBI-10254561, EBI-3905457;
CC Q6UX98; Q0VD86: INCA1; NbExp=3; IntAct=EBI-10254561, EBI-6509505;
CC Q6UX98; P48051: KCNJ6; NbExp=3; IntAct=EBI-10254561, EBI-12017638;
CC Q6UX98; Q5SR56: MFSD14B; NbExp=3; IntAct=EBI-10254561, EBI-373355;
CC Q6UX98; Q9H8W4: PLEKHF2; NbExp=3; IntAct=EBI-10254561, EBI-742388;
CC Q6UX98; Q04864: REL; NbExp=3; IntAct=EBI-10254561, EBI-307352;
CC Q6UX98; Q04864-2: REL; NbExp=3; IntAct=EBI-10254561, EBI-10829018;
CC Q6UX98; Q99942: RNF5; NbExp=3; IntAct=EBI-10254561, EBI-348482;
CC Q6UX98; Q9NPE6: SPAG4; NbExp=3; IntAct=EBI-10254561, EBI-10819434;
CC Q6UX98; Q8TAV4: STOML3; NbExp=3; IntAct=EBI-10254561, EBI-12900395;
CC Q6UX98; Q69YW2: STUM; NbExp=3; IntAct=EBI-10254561, EBI-22730169;
CC Q6UX98; P15884: TCF4; NbExp=3; IntAct=EBI-10254561, EBI-533224;
CC Q6UX98; P15884-3: TCF4; NbExp=3; IntAct=EBI-10254561, EBI-13636688;
CC Q6UX98; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-10254561, EBI-8638294;
CC Q6UX98; O43557: TNFSF14; NbExp=3; IntAct=EBI-10254561, EBI-524131;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC {ECO:0000250|UniProtKB:Q8IUH5}.
CC -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY358448; AAQ88813.1; -; mRNA.
DR EMBL; BC005015; AAH05015.1; -; mRNA.
DR EMBL; BC057833; AAH57833.2; -; mRNA.
DR CCDS; CCDS8143.1; -.
DR RefSeq; NP_997223.1; NM_207340.2.
DR AlphaFoldDB; Q6UX98; -.
DR BioGRID; 129032; 13.
DR IntAct; Q6UX98; 17.
DR STRING; 9606.ENSP00000309429; -.
DR iPTMnet; Q6UX98; -.
DR PhosphoSitePlus; Q6UX98; -.
DR BioMuta; ZDHHC24; -.
DR DMDM; 74758568; -.
DR EPD; Q6UX98; -.
DR jPOST; Q6UX98; -.
DR MassIVE; Q6UX98; -.
DR PaxDb; Q6UX98; -.
DR PeptideAtlas; Q6UX98; -.
DR PRIDE; Q6UX98; -.
DR ProteomicsDB; 67578; -.
DR Antibodypedia; 16343; 99 antibodies from 16 providers.
DR DNASU; 254359; -.
DR Ensembl; ENST00000310442.5; ENSP00000309429.3; ENSG00000174165.8.
DR GeneID; 254359; -.
DR KEGG; hsa:254359; -.
DR MANE-Select; ENST00000310442.5; ENSP00000309429.3; NM_207340.3; NP_997223.1.
DR UCSC; uc001oin.2; human.
DR CTD; 254359; -.
DR DisGeNET; 254359; -.
DR GeneCards; ZDHHC24; -.
DR HGNC; HGNC:27387; ZDHHC24.
DR HPA; ENSG00000174165; Low tissue specificity.
DR MalaCards; ZDHHC24; -.
DR neXtProt; NX_Q6UX98; -.
DR OpenTargets; ENSG00000174165; -.
DR PharmGKB; PA142670531; -.
DR VEuPathDB; HostDB:ENSG00000174165; -.
DR eggNOG; KOG1311; Eukaryota.
DR GeneTree; ENSGT00940000162361; -.
DR HOGENOM; CLU_027721_5_2_1; -.
DR InParanoid; Q6UX98; -.
DR OMA; RMHLTWL; -.
DR OrthoDB; 863846at2759; -.
DR PhylomeDB; Q6UX98; -.
DR TreeFam; TF319523; -.
DR PathwayCommons; Q6UX98; -.
DR SignaLink; Q6UX98; -.
DR BioGRID-ORCS; 254359; 17 hits in 1078 CRISPR screens.
DR ChiTaRS; ZDHHC24; human.
DR GenomeRNAi; 254359; -.
DR Pharos; Q6UX98; Tdark.
DR PRO; PR:Q6UX98; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q6UX98; protein.
DR Bgee; ENSG00000174165; Expressed in parotid gland and 166 other tissues.
DR ExpressionAtlas; Q6UX98; baseline and differential.
DR Genevisible; Q6UX98; HS.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IBA:GO_Central.
DR GO; GO:0018230; P:peptidyl-L-cysteine S-palmitoylation; IBA:GO_Central.
DR GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR Pfam; PF01529; DHHC; 1.
DR PROSITE; PS50216; DHHC; 1.
PE 1: Evidence at protein level;
KW Acyltransferase; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW Transferase; Transmembrane; Transmembrane helix.
FT CHAIN 1..284
FT /note="Probable palmitoyltransferase ZDHHC24"
FT /id="PRO_0000233710"
FT TOPO_DOM 1..18
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 40..52
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..166
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 188..201
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..284
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT DOMAIN 94..144
FT /note="DHHC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00067"
FT ACT_SITE 124
FT /note="S-palmitoyl cysteine intermediate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00067"
SQ SEQUENCE 284 AA; 30176 MW; 67976701B26B3C9E CRC64;
MGQPWAAGST DGAPAQLPLV LTALWAAAVG LELAYVLVLG PGPPPLGPLA RALQLALAAF
QLLNLLGNVG LFLRSDPSIR GVMLAGRGLG QGWAYCYQCQ SQVPPRSGHC SACRVCILRR
DHHCRLLGRC VGFGNYRPFL CLLLHAAGVL LHVSVLLGPA LSALLRAHTP LHMAALLLLP
WLMLLTGRVS LAQFALAFVT DTCVAGALLC GAGLLFHGML LLRGQTTWEW ARGQHSYDLG
PCHNLQAALG PRWALVWLWP FLASPLPGDG ITFQTTADVG HTAS
