ID   ZDH24_RAT               Reviewed;         284 AA.
AC   Q2TGI5;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Probable palmitoyltransferase ZDHHC24 {ECO:0000305};
DE            EC=2.3.1.225 {ECO:0000305};
DE   AltName: Full=Membrane-associated zinc finger protein DHHC25;
DE   AltName: Full=Zinc finger DHHC domain-containing protein 24;
DE            Short=DHHC-24;
GN   Name=Zdhhc24;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Huang C.-H., Chen Y., Ye T.;
RT   "A superfamily of membrane-associated DHHC type zinc finger proteins.";
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable palmitoyltransferase that could catalyze the
CC       addition of palmitate onto various protein substrates. {ECO:0000305}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC         hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC         COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC         EC=2.3.1.225; Evidence={ECO:0000305};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684;
CC         Evidence={ECO:0000305};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC       {ECO:0000250|UniProtKB:Q8IUH5}.
CC   -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; AY886540; AAX73402.1; -; mRNA.
DR   RefSeq; NP_001034189.1; NM_001039100.1.
DR   AlphaFoldDB; Q2TGI5; -.
DR   SMR; Q2TGI5; -.
DR   STRING; 10116.ENSRNOP00000026832; -.
DR   PaxDb; Q2TGI5; -.
DR   Ensembl; ENSRNOT00000026832; ENSRNOP00000026832; ENSRNOG00000019825.
DR   GeneID; 293665; -.
DR   KEGG; rno:293665; -.
DR   UCSC; RGD:1565630; rat.
DR   CTD; 254359; -.
DR   RGD; 1565630; Zdhhc24.
DR   eggNOG; KOG1311; Eukaryota.
DR   GeneTree; ENSGT00940000162361; -.
DR   HOGENOM; CLU_027721_5_2_1; -.
DR   InParanoid; Q2TGI5; -.
DR   OMA; HDGTHWQ; -.
DR   OrthoDB; 863846at2759; -.
DR   PhylomeDB; Q2TGI5; -.
DR   TreeFam; TF319523; -.
DR   PRO; PR:Q2TGI5; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000019825; Expressed in thymus and 20 other tissues.
DR   Genevisible; Q2TGI5; RN.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IBA:GO_Central.
DR   GO; GO:0018230; P:peptidyl-L-cysteine S-palmitoylation; IBA:GO_Central.
DR   GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR   InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR   Pfam; PF01529; DHHC; 1.
DR   PROSITE; PS50216; DHHC; 1.
PE   2: Evidence at transcript level;
KW   Acyltransferase; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW   Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..284
FT                   /note="Probable palmitoyltransferase ZDHHC24"
FT                   /id="PRO_0000233712"
FT   TOPO_DOM        1..18
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        40..52
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        74..137
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..166
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        188..195
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        217..284
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   DOMAIN          94..144
FT                   /note="DHHC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00067"
FT   ACT_SITE        124
FT                   /note="S-palmitoyl cysteine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00067"
SQ   SEQUENCE   284 AA;  30696 MW;  467D931FBD5A369A CRC64;
     MGEPWAARGT EGAPARMPVV FTALWAAVVV LELTYVMVLG PGPPPLEPLA RALQLALAAY
     QLLNLLGNMG LFLRSDPSIR GVMLAGRGLG QGWAYCYQCQ SQVPPRSGHC SACRVCILRR
     DHHCRLLGRC VGFHNYRPFL CLLLHAAGVL LHISVLLSPA LSALLQAHSA LYTVALLLLP
     WLMLLTGKVS LAQFALAFVV DTCVAGALLC GAGLLFHGML LLRGQTTWEW ARGQHSYDLG
     MSHNLQAALG PRWALVWFWP FLASPLPGDG ITFQTPTDVG LVTS