CC168_HUMAN
ID CC168_HUMAN Reviewed; 7081 AA.
AC Q8NDH2; Q8N800;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 3.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Leucine-rich repeat transmembrane protein CCDC168 {ECO:0000305};
DE AltName: Full=Coiled-coil domain-containing protein 168 {ECO:0000312|HGNC:HGNC:26851};
GN Name=CCDC168 {ECO:0000312|HGNC:HGNC:26851};
GN Synonyms=C13orf40 {ECO:0000312|HGNC:HGNC:26851};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4630-5357 AND 6000-7081, AND
RP VARIANTS PRO-4943; PRO-6011 AND GLU-6544.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6640-7081.
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
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DR EMBL; AL157769; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK097495; BAC05076.1; -; mRNA.
DR EMBL; AK125984; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AL833908; CAD38764.1; -; mRNA.
DR CCDS; CCDS73596.1; -.
DR AlphaFoldDB; Q8NDH2; -.
DR IntAct; Q8NDH2; 6.
DR MINT; Q8NDH2; -.
DR STRING; 9606.ENSP00000320232; -.
DR iPTMnet; Q8NDH2; -.
DR PhosphoSitePlus; Q8NDH2; -.
DR BioMuta; CCDC168; -.
DR DMDM; 193806663; -.
DR EPD; Q8NDH2; -.
DR jPOST; Q8NDH2; -.
DR MassIVE; Q8NDH2; -.
DR PaxDb; Q8NDH2; -.
DR PeptideAtlas; Q8NDH2; -.
DR PRIDE; Q8NDH2; -.
DR ProteomicsDB; 73026; -.
DR Antibodypedia; 62446; 9 antibodies from 5 providers.
DR Ensembl; ENST00000322527.4; ENSP00000320232.3; ENSG00000175820.4.
DR MANE-Select; ENST00000322527.4; ENSP00000320232.3; NM_001146197.3; NP_001139669.1.
DR UCSC; uc001vpm.4; human.
DR GeneCards; CCDC168; -.
DR HGNC; HGNC:26851; CCDC168.
DR HPA; ENSG00000175820; Tissue enriched (testis).
DR neXtProt; NX_Q8NDH2; -.
DR OpenTargets; ENSG00000175820; -.
DR VEuPathDB; HostDB:ENSG00000175820; -.
DR eggNOG; ENOG502ST12; Eukaryota.
DR GeneTree; ENSGT00940000163791; -.
DR HOGENOM; CLU_222861_0_0_1; -.
DR InParanoid; Q8NDH2; -.
DR PhylomeDB; Q8NDH2; -.
DR TreeFam; TF337758; -.
DR PathwayCommons; Q8NDH2; -.
DR SignaLink; Q8NDH2; -.
DR ChiTaRS; CCDC168; human.
DR Pharos; Q8NDH2; Tdark.
DR PRO; PR:Q8NDH2; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; Q8NDH2; protein.
DR Bgee; ENSG00000175820; Expressed in sperm and 10 other tissues.
DR Genevisible; Q8NDH2; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR031624; CCDC168_N.
DR Pfam; PF15804; CCDC168_N; 18.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..7081
FT /note="Leucine-rich repeat transmembrane protein CCDC168"
FT /id="PRO_0000342529"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 233..256
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT REPEAT 420..445
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 865..890
FT /note="LRR 3"
FT /evidence="ECO:0000255"
FT REPEAT 1050..1075
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 1501..1527
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 2373..2397
FT /note="LRR 6"
FT /evidence="ECO:0000255"
FT REPEAT 2727..2749
FT /note="LRR 7"
FT /evidence="ECO:0000255"
FT REPEAT 2832..2855
FT /note="LRR 8"
FT /evidence="ECO:0000255"
FT REPEAT 2862..2889
FT /note="LRR 9"
FT /evidence="ECO:0000255"
FT REPEAT 3433..3458
FT /note="LRR 10"
FT /evidence="ECO:0000255"
FT REPEAT 3630..3653
FT /note="LRR 11"
FT /evidence="ECO:0000255"
FT REPEAT 3875..3898
FT /note="LRR 12"
FT /evidence="ECO:0000255"
FT REPEAT 5311..5336
FT /note="LRR 13"
FT /evidence="ECO:0000255"
FT REPEAT 5522..5545
FT /note="LRR 14"
FT /evidence="ECO:0000255"
FT REPEAT 5901..5924
FT /note="LRR 15"
FT /evidence="ECO:0000255"
FT REPEAT 6259..6282
FT /note="LRR 16"
FT /evidence="ECO:0000255"
FT REPEAT 6419..6442
FT /note="LRR 17"
FT /evidence="ECO:0000255"
FT REPEAT 6552..6575
FT /note="LRR 18"
FT /evidence="ECO:0000255"
FT REPEAT 6613..6637
FT /note="LRR 19"
FT /evidence="ECO:0000255"
FT REPEAT 7012..7036
FT /note="LRR 20"
FT /evidence="ECO:0000255"
FT REGION 717..745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 943..1009
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1274..1304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1773..1804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1954..1973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2008..2031
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2083..2103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2637..2680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3730..3756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4119..4260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4293..4428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4729..4756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4794..4817
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4831..4859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4928..4955
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4966..4985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5191..5212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5467..5496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5564..5583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5763..5792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6859..6878
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6916..6950
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 943..972
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 984..998
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1773..1787
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2009..2023
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2640..2654
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2663..2680
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4143..4180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4195..4260
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4326..4363
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4375..4427
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4836..4859
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5472..5496
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6932..6950
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 4659
FT /note="P -> S (in dbSNP:rs11843669)"
FT /id="VAR_044210"
FT VARIANT 4723
FT /note="M -> V (in dbSNP:rs17592459)"
FT /id="VAR_044211"
FT VARIANT 4893
FT /note="G -> S (in dbSNP:rs9518825)"
FT /id="VAR_044212"
FT VARIANT 4943
FT /note="S -> P (in dbSNP:rs9300758)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_044213"
FT VARIANT 4976
FT /note="L -> P (in dbSNP:rs9300757)"
FT /id="VAR_044214"
FT VARIANT 5011
FT /note="G -> A (in dbSNP:rs17507841)"
FT /id="VAR_044215"
FT VARIANT 5644
FT /note="R -> T (in dbSNP:rs7982465)"
FT /id="VAR_044216"
FT VARIANT 5750
FT /note="N -> S (in dbSNP:rs7983175)"
FT /id="VAR_044217"
FT VARIANT 5838
FT /note="R -> Q (in dbSNP:rs17592438)"
FT /id="VAR_044218"
FT VARIANT 5916
FT /note="F -> L (in dbSNP:rs7335290)"
FT /id="VAR_044219"
FT VARIANT 6011
FT /note="L -> P (in dbSNP:rs6491707)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_044220"
FT VARIANT 6075
FT /note="R -> C (in dbSNP:rs9300756)"
FT /id="VAR_044221"
FT VARIANT 6112
FT /note="T -> M (in dbSNP:rs17507827)"
FT /id="VAR_044222"
FT VARIANT 6508
FT /note="E -> A (in dbSNP:rs9514051)"
FT /id="VAR_044223"
FT VARIANT 6544
FT /note="K -> E (in dbSNP:rs9554897)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_044224"
FT CONFLICT 6626
FT /note="L -> P (in Ref. 2; AK125984)"
FT /evidence="ECO:0000305"
FT CONFLICT 6689..6699
FT /note="LIRKFPQPTLV -> RSEAHTRVG (in Ref. 3; CAD38764)"
FT /evidence="ECO:0000305"
FT CONFLICT 6865
FT /note="R -> S (in Ref. 2; AK125984)"
FT /evidence="ECO:0000305"
FT CONFLICT 6908
FT /note="K -> N (in Ref. 2; AK125984)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 7081 AA; 801912 MW; 6190452D9844F72E CRC64;
MSKQYYSFKK GVGSGLEDNT FMTLWDFLES WIIQNDWVAI FFIILLGIIF EIILMKACAS
FWKKPTLPEK GSSDVQETED SCPKSRKLAP ENWSVINSSS GERVGTFLEK RITSSLTSEE
KECNFEDRIL FSREILWSGT SESEDQVSPS SESHVPSSNG ISSSLPLFYS EVEETCLSHT
EHPDREYETI QFSSKKLFSM MKTNKNKNSG FSSDLSFSAS RFTVENEDLD VAPCPLAHLF
LSRDQVRLLE ENVRNQIPSK PKTKLGSRTT YQCSRSQESL NQNQPSVGMV ISVQAQDSFP
GQNAFQNQGL YEVQFTSQAQ YINHNQESIK SQPESKASNF AQPEDVMKKP FSSSTQDSFQ
SQDLDRNQHF VEVPSIVEAK YSVKGLESDE HLGEDQHCVW FIDSNKVKYS IKGQDTIFKN
AEFLVLTLNP NLVTEDMPQL RSVKAQGQQQ IVSSELNQDS VYSSVPLLST IKGQKNRRKT
PDSKSKLSLN VPSLKAKKTP TSQVFQITVC HTLKNRNELG CKNNTEKKEL HERKDISDIA
LHLISVSKLI LPYVKNYSRK QLVKVMPGLI KCGHFLQKQN KSPDTEKINY AGPLEETGIS
DITKKEKEYD KENKRLKNIS PKMLPQLEQS FMVNTVQLKA PCLLVETNGK SKESLKDSIT
QAKGIGITEF HVLNSKKPFD LHIPKHKTSL EEAISKPMQK LVSSPEMESN NRMKIQEDLQ
SSENSHLQLS NGEELPTSTP KTQRCFPREN TQKQKDFLEL VLELSNVGLL ISPGSKMHKS
SEELEAIKIQ VNTESVNLKE SKPLILNVTE DSDLRESEEL ECNTGSNITN MHQDKETSDA
FHSATYTTIS QLPDTETHSI SKAKADTLRI IRLSHSASKQ EKLPDEKETQ NAEYIDKSCT
FKKPQQCDRK EQEKEANSEL TQGFRFSIHL KQKPKYVKFQ MEQISSGSSK APNKEQEVQP
QTLSTQTILE NSPCPMMDPF QVEKVKQSTD RPTDRESAGD PKNPLTMPEN LPVGELLIET
TEYSVPFGGN LQKTTDSHIA EEKEDVKRYL PAVALGSFNN HLLTLPYFKR QEIKKKLSET
KSVLSVKYVI MKVKKPAISL MPYINICGTS NHRKKMGGNF EIIIKQILQD KIAAGMLLNV
IYPPMSILPN TRMYSRLNAE NHSHIKLVQE ESQIEREEKY PYFINEGNES QNTLDAKLQD
EVKGVKETLP KAVLHDSCNL GLDAHLEKEI KTEKEMHQPI PFTETIIESV VSPIMELSHA
ENVKSTQKTQ TDCKCTADSE TPSPISGKSL IGDPLNQTRE SYIPSNGSDT REMGYCFAEE
KTEIPKDLPA TSPETFNYCT PVLSCSKVMK KRVTFALTTS TAKPKCVNTK AVKPSISETV
SVTSHRKKSE LDFKTKFKKI NQTKGLVPEC LNTLCSPMHS RLQREFCLPA SQLKQGETAD
KTYTDVFAKN SISHDREEKL QDGKEEEHKV LLEAAPQLSQ HLGSEAGQMK EIHLESDPVL
NCLTLELHIN GQRLQHQTGF EQTTLETSLQ MGPLEAEELQ KANETENDIK VLGGPKIPPP
KALQALENSD GLILNAYQKD NELVKSDEEL NQPGSTNIQV QPQTHFTQTI LKSTSCPTLD
QFPFEKVESH VRFSPLKSGE AKVDEIIFYA REGGISSDSS HQKEQAGGTE KKETAIFGSC
MPALSTPKTT RNLKQFSDMK TLVNPKCGII KAKKPSISYM LNIRAGAGPK RRKELSCNLT
TKMKELHQGK KGVDETYAFL TMTPDINKYS KVETEKDTLR EKRLSSTQVK QDTSPHEDSI
TSRDIKETLL QDEEQEERKQ EALLKVIPQH LQHFMFRSGQ GKDLDFHKLE NQGSRKILFV
TKQDVPQQLQ PAEPIQREET KKCLQTQNGT ICTVNSKLLP LKSEDSVNGE VLTGAIKRGV
PTDRKCMGEQ HNSGKGEKAE FNKDLQATVL ELQKSPHGGE AQKANLTDME SGSSNAMNMN
VQHEREDKNI QKMLTESVPC YSQHLRFSTH QMKDPDPCKS GSEPKSPEGR SWNLSHIVQK
TKQETHFRET VLEPISGYMM KQSPHMQEGI KCMEGLKTSF PKTGKSKIGS IPRDTPWDEN
PRRKWDSSIS EKTAWNQKNL QTVLKPLDFS SLMSSEYESR SYTLEFIGKK SMSPKCVTLK
AKQLRILQLF NIIRYSTENH RKKKQHRFKY KMKGKQWYTS IGEALLSATE YAKSTTSKSM
IDKLLYNTAA RCILSNRTRR QNLDGHITEE KEEVQENVAA IFLGLLDFFM PVLSDSKNQR
NTAQLSEKEI IFNAKCLTMK EKKSSISQIH KINRESTRKH RKKCKSYLKT VSNRKCQENH
GHITEEEEEV QENSPATFLG PLDFFMPVLS DSKNQINTIQ LSERKIILNP KCLTMKEKKP
PISQIHKISG QFTTKHRKKL ESNLKTKLKA MWQGENVADT FPNTTSFTPD SSDIKRQSGF
QTEIDMRISG LSHTQPTQIE SLAEGIARYS DPIDKRRTSN LVKGAKLHDR ESGEEKQEHL
TEMDPFYAEN FMANTYLRKD RHLGKSEDVL LGETFFSKSQ IYKGNSEKNV KIEKNKNGKE
SLKVGLARME KSDNCAELSE ATDDAISNKY DKQNIGHSVL KENAFCNLAA IVPDSVGRHS
PASEEMKRQN GRLKMADRSS PQGRPLQAKQ SAVSQSPDTA GYAVVSNNKE QKQNFKAQKT
EAEVDLIDQE AKINVAEEFN PESVFFSKIH PLQIENKKEF KTADWKTRAD PKTFALPKKQ
QELCVSGTIW SYPNPYTSIS PKIIRHKDKA KTADVESTMH TKQIKLKAKR ITVSQLLEYG
TASNKKELRG NIQQQKSFQL SKNAVHRVLK AVYDSGYCVS SIKKLTEVKM EKDKPKDRTC
ILPQPKLEKP LKEMQRSLSG CTDMSSILRK QEQDIREKEQ KHQSISEDIS QYYIGPLRIS
SQQINYSSFD APRIRTDEEL EFLIAQRAKE KDVGIAKHSV SIPWEREGSK RLDIPLNSKG
QNIFFTELDT SQQKTCQEQE LLKQEDISMT NLGSMACPIM EPLHLENTGK VTEEEDVYIN
RKISSHVLGK EGLKETDIFV GSKGQKFLCT NSEVQHKVPA EQKEQVNPDH VPESILDSES
FLSKDPLHLK QAVNTARKEN VTISESFNEN LWGKEQSKLD ITLKSNRQKM DFSKKLRMKH
LSNYYQNKEN ILESVLPCIL HQLYIENPKK EGSAEEIMSS KVLSPMVEKA SHEVGIPVDQ
PPCSEGIHLN IKGRKEHPQE STHEAFPASV SHSLMDVLQI KSPKVKKALK AINSLGYLTS
NTKGIGLLFP RQAEKEEKYT YKALPKPASH SKTDLFQFNA SMQQEKLDAM DIPHYDYLTS
QTREAVKQMD VIVGYTQNSK KRQDLLKTGQ KWQYLPISYE NFWEHISCPQ KYPCLLQHLM
PQEKEALSEG GNLSSRTPGL DLFSADQLST ITKNRLEWIV PLISPRQMKK QDSMLPLGSY
HKTIKYASLL FPKGMKSSDG VQVFDLISNN SSPKLRLGKK IETQKANEKV QKEVCLPITL
HSLSASMPIL QESKGQKDSV EQVIRKGVIC HKRRTSKWKK SVFSHILNTS DCGASSNRLE
MQWNMTDKMV NVKHRMSEID LVAAKICESI LSLPHFKLNK ETIDGVISSN VKSTKQHISQ
GKNDRVKAMD MKRIKSPNII LKPRKSSLSH ILSIKEFPLL LDIIKQEGKM QEGKGKSSMK
LTNLCTSLPS LSHSNSNSRT KAGKDKSGTL KGCLPPLKLQ ASSNARRVSS AESINRDSLS
NVIESKCFPQ KKKEDRENIV DVKDVMGLKC ITLKGKKSLF RHLLHGKEPQ RSNKKLEKMT
QEDESNLNVV QNKLCASILS PPHLEWNPRI KEVYMRGITR FCLSSSTQQE LSDTMEKCEQ
PIDDSLSSIE KAKHMPQKDK DRVEKALEKI MHSKRIALEV KQPSIFQELE LNIKEKGGKI
QEDKEVEIWS KPFASISFLP YSKVGTIEGE EAMRIKMRSS FSQPNLQESS DTEKTAYEKC
ISDNISNSVK KALESILQKE QRQKMEKIRA LKKMKSSISQ GIQLDIKEQE KRIEHIKGEP
SVLLTNACAS IPSPSHLQLD TRREKAEYVT EITRYYLPEL SHQKSSEAGE KADGVASKGD
ITIKVQKAKD YMQQKEDDEV KISAKKDIMH PEDKGLKAKK ALSQDLPLNT KEPGKMDQEA
QEQGKEDREG EEQGKEDRRG AGQEKVDRED KEQGKMDHEV EEQQKADGVG IEQGKMDGDK
NEQERVLFLY LPSNSSLTHY ILDTRIEGEE DQQGIIRPGI LQPRHQKSSE TGKKANGVPS
EGDSASEVQK AKDYMQQKEE DEVKISAEKD LMHPEDKDLK GKKALSQNLP LNPKEPGKRD
GEGQEQGKED GEGEEQGNRD GETEEQQQAD GVGTEQEKRD GHKSKQETVL FLHLPSESSL
TCYELNTRKE GEEDLQGIIK SATLQLRQQK SFDAGKIAHT KSFGVDSSND VKTVQEYKPQ
KEVDRGKTVS VDYIMQPEGT IFEAEQLSLP HTLNIPGSSG SKTREVLTNI KEKLRHVQER
KSELDVFLTI PSLSHCKLDK RTAGKKEEQG VTRSFLPPSW HMESSDTGKL KYTLSYLNDI
TGDSNRTKYM AQIQKDKANI SEKSVMHPEY IAVKAEKSPL SHILKTKELQ VNISQQGEKA
QEGEVEIVVL LSKTCPFVTS SAFLELDSIK EEEGEPRITR SFMPHLEIQE SLPSRQTAPT
KPTESLVKKE KQLLPQKEDR VQTVSMHGLM HPNGAVFKAK TSAPPQVFSI TEHSPLSKRK
EPQWGMKERA GQKQDRTGRP HVILTKTHPF MPSLSHHRFS PSQPKLPISS GAGKSRLANS
NEGISSHKVI LKANQQMPYK EAKDRVKIEG REGRILPKRI HLRAEALPLA LLCNGKNYSL
HIEEQGEGVQ ESKKEPGVVP RKSASFPPPP FYLNCDTRRN EKEGTLGKTQ FSFPPLKIQD
SSDSGKKAYT ESLHGYTLSN SKGPVQPTAQ GEEKGGLRID MEDKMLPKCT DLKAKQLLLS
DILNTKKLQW KSKEQKRKIQ EDKNKQVKGL PSINTSLLTP PYLKFDTTEG QENVIRIAKV
SLPQSRSKES SDAGRIACPE ATHGELSSDV KQLKAHLLQK EEKDREKVAD MTSVLDPNKM
YLKAKKSPVL HTHSFSDLQW KTREQEEEKV QKVKSGPGVM LSKSPSRSSP LHLNVNTGFQ
EESIPILTRP SFPLVKLQVS PDTEGGTCIR PIAGDILIYL QKGKHVSQNK EEDDVQIVSI
LIFPKHQEEK VQECEGEPGV VLTKSTSLPS LSQLELDKET HLGNEMLRLK RPILRRISHI
GETVHRESVV GDIPKDVKNE KQHIPQKEER NQKKIIDMRG TDITLKSKKS PRSCMLHRTE
LHVNIGGQGR KEHEGQDKPP GMIQRKMCIL FSKPLPSNLK LERATHADEE RLGGKTSFVL
PLMPSALPDT EKTADAEARS GDVRKGKPHR SQKENRHEVK TIDMRFRIHC QEARISPMSH
ILNAKELVLN INKLEKKVHK DKDEACVVLS RTFLSIPSAP PLYLDSGNKT DKDTPGITGS
SCPQRTLHVP SNTQKITNRD SVEGVDKNVV KQAEQYVPRP EAEQQLTSNF MISVQQRNQP
SRVRSEEDLN QLVLNSRDED IYFTGFGTIR SGKRPEWLFT GKKAQPVKYK TETLTAFLSY
PTMDATKMGG LEEDTEIMDN LNHKISPKAS VSLIRKISKE LYVTLGTPAN SKGFSVSERY
AHQQETSSKV SPELAGSCKF DKPKEDGQSN DRISKMFSPK VLAPQTKGSL KKISIVTNWN
APQNIEEQDI VMKKQVIRRC EHGHKTRTNT ILSKFPLQSG KQKTPSETDV DKKTTAHLSL
QMLPGIHMDM TEIDPAKGGR KQALLISEQE EGVLEFLPKS LFPPWTFQFQ SGDLEEKHQT
DANTNINLEQ KKLEMDNDST VNQKEGKLKI GTNRALHLQE EKTEMHKART ANLEKERGRM
DTSSSAHPHL LSLKAEESQM KTQVITHREN SRLIMQKQKK ELEASNAKQS IQLQKLFQRN
VLDSFYSYVP LSPKRKDQKG RLTIRDLKRE LSTKYLTMKI QNHPIPQMLN ITGRGTPSNR
KKLEYDVKLK NIASWSKDVS GIFIRSLSIS IMRSPHTDPK TNLEREKRIC LPKFQEKSPN
TSEMSKRDTL TIVKGEQNFT NTVPQDPQPF AVDKQQMQKL PNVKSEANLR SEMNKKYLKA
QTKERIVPEH DVSRIIKKPD LRIIEQEEKI LKRILTPTEC PSMLEDPKLP KQRDQSEPVW
DMTTQKVQQQ KAFPGTVPIP PQVKSSEVKI VADSTNAEHL LPICEATKAI SESQVKNMIQ
DKVSSDKLDN IQAYKPDDLK SPPFPEGPDT ISTAIYPKTQ HKSLLEQFTP KEKNKLTSHL
ESKALEIQLN LIPEMARKSL QMFNFYPKGT ISKDNSWRFY SRHKTMNFMS LEGTDTIEPN
SKHKHQKDSP LASNMKTLIV DVSSDSEETI TKLQSINKLE NGTSAVTSAS EMLLPHTLQN
HSVKEKGKLL MHFSVKTLEI QMKAFPRIVR ESYAMTSAHE RKKPLSNCIH PGFTGPKRQN
RILLLSEEKS LHQIDLDLQY KYLRFLLGLP VGSTFPKPNV LPKHSKLNTI AVCKNVNAGG
QSGSLSIDTE LLEQHISFKK QSPHENSSLI RKFPQPTLVC ASDRDLHSPR KKDTQVLSES
EFHVTPEKNK QYHVWFQERN TCESVDLRTQ RNATGSAVSC ETQISEDFVD IQTDIESPAD
LDECSCLEVS ESEECVFLEA NSYLSQESEN ILFELQTGIP LENVYKITTD LKSFYSEDSG
SHCTRECRKE TLIITPPSCK SHKSRKYRSS SKMKSPDWLC HSSSNTAEIQ SRSSSVSFSE
EKISWTTKSR TSYSSAPLTE SNIKSHLAKN QGKSHRHPES QERKKARSDL FRKNSSHWDH
DYSCTHSKGK RDRKKRVYDY ESERLDCFQS KHKSASKPHH DDINFYSERK QNRPFFFACV
PADSLEVIPK TIRWTIPPET LRKRNFRIPL VAKISSSWNI WSSSKKLLGS LSGSLTTVFH
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