ZDHC2_DICDI
ID ZDHC2_DICDI Reviewed; 446 AA.
AC Q86A83; Q555W9;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 2.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Putative ZDHHC-type palmitoyltransferase 2;
DE EC=2.3.1.225;
DE AltName: Full=Zinc finger DHHC domain-containing protein 2;
GN ORFNames=DDB_G0274739;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2] {ECO:0000305, ECO:0000312|EMBL:EAL70262.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000312|EMBL:EAL70262.1};
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 84-169 AND 378-446.
RC STRAIN=AX4;
RX PubMed=15010511; DOI=10.1093/nar/gkh262;
RA Urushihara H., Morio T., Saito T., Kohara Y., Koriki E., Ochiai H.,
RA Maeda M., Williams J.G., Takeuchi I., Tanaka Y.;
RT "Analyses of cDNAs from growth and slug stages of Dictyostelium
RT discoideum.";
RL Nucleic Acids Res. 32:1647-1653(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC EC=2.3.1.225;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC {ECO:0000250|UniProtKB:Q9NYG2}.
CC -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC {ECO:0000255}.
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DR EMBL; AAFI02000012; EAL70262.1; -; Genomic_DNA.
DR EMBL; AU053196; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AU053698; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AU060371; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AU062170; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; XP_643941.1; XM_638849.1.
DR AlphaFoldDB; Q86A83; -.
DR SMR; Q86A83; -.
DR STRING; 44689.DDB0203296; -.
DR PaxDb; Q86A83; -.
DR EnsemblProtists; EAL70262; EAL70262; DDB_G0274739.
DR GeneID; 8619369; -.
DR KEGG; ddi:DDB_G0274739; -.
DR dictyBase; DDB_G0274739; -.
DR eggNOG; KOG1315; Eukaryota.
DR HOGENOM; CLU_614567_0_0_1; -.
DR InParanoid; Q86A83; -.
DR OMA; NCVGLFN; -.
DR PhylomeDB; Q86A83; -.
DR PRO; PR:Q86A83; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IBA:GO_Central.
DR GO; GO:0018230; P:peptidyl-L-cysteine S-palmitoylation; IBA:GO_Central.
DR GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR Pfam; PF01529; DHHC; 1.
DR PROSITE; PS50216; DHHC; 1.
PE 2: Evidence at transcript level;
KW Acyltransferase; Glycoprotein; Lipoprotein; Membrane; Palmitate;
KW Reference proteome; Transferase; Transmembrane; Transmembrane helix.
FT CHAIN 1..446
FT /note="Putative ZDHHC-type palmitoyltransferase 2"
FT /id="PRO_0000259606"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 305..325
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 349..369
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 261..311
FT /note="DHHC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00067"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 56..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 14
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 21
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 141
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 145
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 165
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 446 AA; 51496 MW; FFAB59277FA1AC5D CRC64;
MNLYNNSNSS GSSNSSSSSN NKTNIDYNDI NNNDILTPKG YHTSIYIDDN DLNNNQIINK
NNNNNHNRNN NNNNNNNNNH NNPKKMVINL NPSGIFIPLM NDFDDDDDDE QESLIKNNKI
TIPTINSQIA IPILNNNDNN NNSNNKTEQT TTTTTIIKNT TIFNNKTISF GRIGFRSIVI
FLILVPYIYI LNFAIFPWTV NYETERKGKI HSFISMALVI QMLCNYYLCS TTDPGSFKDT
ISPSYYLLHP ISSTDSNDHK KWCNKCNHQK PERAHHCRYC NRCVLRMDHH CQWLQNCIGL
FNQKYFVLFL FYTSISIIYF FTLLIKRSIE LVTKYTMEKT LPSFDLLHLF LLGILIIILI
IAGISIMALL WTQIALISKG LTTIEHEDKK RKYQQPNYLN LYKKYDKGSI ISNFSIVFGN
LSFLWLLPTI PNNLKITSKK GDIFIV
