CC169_HUMAN
ID CC169_HUMAN Reviewed; 214 AA.
AC A6NNP5; A6NC13; A6NCT2; B7ZW45; B7ZW49; B9EJF2; Q9H1T4; Q9H1T5;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 4.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Coiled-coil domain-containing protein 169;
GN Name=CCDC169; Synonyms=C13orf38;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
RC TISSUE=Hippocampus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 6).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=A6NNP5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A6NNP5-2; Sequence=VSP_035636, VSP_035637;
CC Name=3;
CC IsoId=A6NNP5-3; Sequence=VSP_040479, VSP_040480;
CC Name=4;
CC IsoId=A6NNP5-4; Sequence=VSP_040480;
CC Name=5;
CC IsoId=A6NNP5-5; Sequence=VSP_040479;
CC Name=6;
CC IsoId=A6NNP5-6; Sequence=VSP_043810, VSP_043811, VSP_040480;
CC -!- SIMILARITY: Belongs to the CCDC169 family. {ECO:0000305}.
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DR EMBL; AK308999; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AL139377; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC146975; AAI46976.1; -; mRNA.
DR EMBL; BC171867; AAI71867.1; -; mRNA.
DR EMBL; BC171872; AAI71872.1; -; mRNA.
DR EMBL; BC171874; AAI71874.1; -; mRNA.
DR EMBL; BC171880; AAI71880.1; -; mRNA.
DR EMBL; BC171881; AAI71881.1; -; mRNA.
DR EMBL; BC171882; AAI71882.1; -; mRNA.
DR CCDS; CCDS45027.1; -. [A6NNP5-3]
DR CCDS; CCDS45028.1; -. [A6NNP5-1]
DR CCDS; CCDS45029.1; -. [A6NNP5-5]
DR CCDS; CCDS53863.1; -. [A6NNP5-6]
DR CCDS; CCDS55897.1; -. [A6NNP5-4]
DR RefSeq; NP_001138453.1; NM_001144981.2. [A6NNP5-1]
DR RefSeq; NP_001138454.1; NM_001144982.2. [A6NNP5-3]
DR RefSeq; NP_001138455.1; NM_001144983.2. [A6NNP5-3]
DR RefSeq; NP_001138456.1; NM_001144984.2. [A6NNP5-6]
DR RefSeq; NP_001138457.1; NM_001144985.2. [A6NNP5-5]
DR RefSeq; NP_001138458.1; NM_001144986.2. [A6NNP5-5]
DR RefSeq; NP_001185837.1; NM_001198908.1. [A6NNP5-4]
DR AlphaFoldDB; A6NNP5; -.
DR SMR; A6NNP5; -.
DR BioGRID; 609013; 1.
DR STRING; 9606.ENSP00000426174; -.
DR iPTMnet; A6NNP5; -.
DR PhosphoSitePlus; A6NNP5; -.
DR BioMuta; CCDC169; -.
DR jPOST; A6NNP5; -.
DR MassIVE; A6NNP5; -.
DR PaxDb; A6NNP5; -.
DR PRIDE; A6NNP5; -.
DR Antibodypedia; 52943; 15 antibodies from 3 providers.
DR DNASU; 728591; -.
DR Ensembl; ENST00000239859.8; ENSP00000239859.7; ENSG00000242715.8. [A6NNP5-1]
DR Ensembl; ENST00000239860.10; ENSP00000239860.6; ENSG00000242715.8. [A6NNP5-6]
DR Ensembl; ENST00000379862.6; ENSP00000369191.2; ENSG00000242715.8. [A6NNP5-5]
DR Ensembl; ENST00000379864.6; ENSP00000369193.2; ENSG00000242715.8. [A6NNP5-3]
DR Ensembl; ENST00000491049.6; ENSP00000425252.1; ENSG00000242715.8. [A6NNP5-3]
DR Ensembl; ENST00000503173.5; ENSP00000426174.1; ENSG00000242715.8. [A6NNP5-4]
DR Ensembl; ENST00000510088.5; ENSP00000427495.1; ENSG00000242715.8. [A6NNP5-5]
DR GeneID; 728591; -.
DR KEGG; hsa:728591; -.
DR MANE-Select; ENST00000239859.8; ENSP00000239859.7; NM_001144981.3; NP_001138453.1.
DR UCSC; uc010abm.4; human. [A6NNP5-1]
DR CTD; 728591; -.
DR GeneCards; CCDC169; -.
DR HGNC; HGNC:34361; CCDC169.
DR HPA; ENSG00000242715; Tissue enriched (testis).
DR neXtProt; NX_A6NNP5; -.
DR OpenTargets; ENSG00000242715; -.
DR PharmGKB; PA162378105; -.
DR VEuPathDB; HostDB:ENSG00000242715; -.
DR eggNOG; ENOG502S1I0; Eukaryota.
DR GeneTree; ENSGT00390000011174; -.
DR HOGENOM; CLU_2090285_0_0_1; -.
DR InParanoid; A6NNP5; -.
DR OMA; IRHEKQM; -.
DR OrthoDB; 1431259at2759; -.
DR PhylomeDB; A6NNP5; -.
DR TreeFam; TF329642; -.
DR PathwayCommons; A6NNP5; -.
DR BioGRID-ORCS; 728591; 23 hits in 1042 CRISPR screens.
DR GenomeRNAi; 728591; -.
DR Pharos; A6NNP5; Tdark.
DR PRO; PR:A6NNP5; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; A6NNP5; protein.
DR Bgee; ENSG00000242715; Expressed in sperm and 106 other tissues.
DR ExpressionAtlas; A6NNP5; baseline and differential.
DR Genevisible; A6NNP5; HS.
DR InterPro; IPR028022; DUF4600.
DR PANTHER; PTHR28671; PTHR28671; 1.
DR Pfam; PF15372; DUF4600; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..214
FT /note="Coiled-coil domain-containing protein 169"
FT /id="PRO_0000341366"
FT REGION 155..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 29..154
FT /evidence="ECO:0000255"
FT COMPBIAS 155..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..102
FT /note="Missing (in isoform 3 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_040479"
FT VAR_SEQ 1..100
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_043810"
FT VAR_SEQ 101..105
FT /note="ERMPV -> METLQ (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_043811"
FT VAR_SEQ 106..115
FT /note="ESLNTLLKQL -> VSRNVIKHKE (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_035636"
FT VAR_SEQ 116..214
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_035637"
FT VAR_SEQ 183..214
FT /note="GRYNPAKQKTVSAKRGPVKKITRPNHLPELHP -> LLLKEELDPLKVSCLE
FT TLGFSAAGVAGPENRTCLGQKALWPACLHGSSTLAVCQTHLKS (in isoform 3,
FT isoform 4 and isoform 6)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040480"
FT VARIANT 120
FT /note="K -> R (in dbSNP:rs9546897)"
FT /id="VAR_057811"
SQ SEQUENCE 214 AA; 25253 MW; DB509F614FFB574B CRC64;
MKEERNYNFD GVSTNRLKQQ LLEEVRKKDA VQLSIFELRH KITELEAKLN TDNEGSEWKT
RYETQLELND ELEKQIVYLK EKVEKIHGNS SDRLSSIRVY ERMPVESLNT LLKQLEEEKK
TLESQVKYYA LKLEQESKAY QKINNERRTY LAEMSQGSGL HQVSKRQQVD QLPRMQENLV
KTGRYNPAKQ KTVSAKRGPV KKITRPNHLP ELHP
