ID   ZDHC4_CAEEL             Reviewed;         403 AA.
AC   Q8I0G4;
DT   30-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Zinc finger DHHC domain-containing protein 4;
GN   Name=dhhc-4; ORFNames=ZK757.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA   Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA   Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA   Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA   Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA   Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA   Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA   Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA   Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA   Wilkinson-Sproat J., Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; Z29121; CAD54174.2; -; Genomic_DNA.
DR   EMBL; Z22180; CAD54174.2; JOINED; Genomic_DNA.
DR   RefSeq; NP_001023032.1; NM_001027861.5.
DR   AlphaFoldDB; Q8I0G4; -.
DR   SMR; Q8I0G4; -.
DR   STRING; 6239.ZK757.4b; -.
DR   PaxDb; Q8I0G4; -.
DR   EnsemblMetazoa; ZK757.4a.1; ZK757.4a.1; WBGene00014075.
DR   GeneID; 191420; -.
DR   UCSC; ZK757.4a; c. elegans.
DR   CTD; 191420; -.
DR   WormBase; ZK757.4a; CE32089; WBGene00014075; dhhc-4.
DR   eggNOG; KOG1315; Eukaryota.
DR   GeneTree; ENSGT00940000168393; -.
DR   InParanoid; Q8I0G4; -.
DR   PRO; PR:Q8I0G4; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00014075; Expressed in embryo and 4 other tissues.
DR   ExpressionAtlas; Q8I0G4; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IBA:GO_Central.
DR   GO; GO:0018230; P:peptidyl-L-cysteine S-palmitoylation; IBA:GO_Central.
DR   GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR   InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR   Pfam; PF01529; DHHC; 1.
DR   PROSITE; PS50216; DHHC; 1.
PE   4: Predicted;
KW   Acyltransferase; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW   Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..403
FT                   /note="Zinc finger DHHC domain-containing protein 4"
FT                   /id="PRO_0000065548"
FT   TRANSMEM        17..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          132..182
FT                   /note="DHHC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00067"
FT   REGION          365..403
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        384..403
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   403 AA;  46452 MW;  7F7BA549B147DE42 CRC64;
     MSCRDCTRKG GCVYTTFWLV RFLPVVLVSL ATGWGIYAYT YELCILSIDN WPQRIIYLFI
     FYALLILFYT SYLRTVYTKA WKPPQKYCIE GASKATYESV KDDERQLQLF LSDIARERDL
     TLLVRGFDHG IRFCDKCCCI KPDRSHHCSM CEQCVLKFDH HCPWVNNCVN FGNYKYFILF
     LAYGFIFCIW IAATTLPSFI DFWRHEYDMN KKQYDSIDSV IQRNLKHLHT VLSNGRFPLV
     FLLFLSCMFS LSLSFLFFYH LYLTAKNRTT VESFRAPMID GKYAKDAFNH GIRANYREIF
     GSHPLYWFLP VPSSIGDGCK FVMNDMTAMS AAAGNQVFVE MGNVPNGQSH AHPPIAQHHI
     NLYSEQSSSA SEKEIKSVDD EITERSQVST ATTASPSHDS VTA