ZDHC4_HUMAN
ID ZDHC4_HUMAN Reviewed; 344 AA.
AC Q9NPG8; A4D2N9; Q53EV7; Q6FIB5; Q9H0R9;
DT 01-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Palmitoyltransferase ZDHHC4 {ECO:0000305};
DE EC=2.3.1.225 {ECO:0000305|PubMed:26535572};
DE AltName: Full=Zinc finger DHHC domain-containing protein 4 {ECO:0000312|HGNC:HGNC:18471};
DE Short=DHHC-4;
DE AltName: Full=Zinc finger protein 374;
GN Name=ZDHHC4 {ECO:0000312|HGNC:HGNC:18471}; Synonyms=ZNF374;
GN ORFNames=DC1, UNQ5787/PRO19576;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Dendritic cell;
RA Li Y., Peng Y., Li N., Gu W., Han Z., Fu G., Chen Z.;
RT "Novel genes expressed in human dendritic cells.";
RL Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Fetal brain;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT MET-53.
RC TISSUE=Testis;
RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [10]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cervix;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [11]
RP SUBCELLULAR LOCATION, TOPOLOGY, DOMAIN, AND MUTAGENESIS OF ARG-340; LYS-341
RP AND LYS-342.
RX PubMed=21926431; DOI=10.1074/jbc.m111.272369;
RA Gorleku O.A., Barns A.M., Prescott G.R., Greaves J., Chamberlain L.H.;
RT "Endoplasmic reticulum localization of DHHC palmitoyltransferases mediated
RT by lysine-based sorting signals.";
RL J. Biol. Chem. 286:39573-39584(2011).
RN [12]
RP FUNCTION, CATALYTIC ACTIVITY, AND SUBCELLULAR LOCATION.
RX PubMed=26535572; DOI=10.1371/journal.pone.0140661;
RA Ebersole B., Petko J., Woll M., Murakami S., Sokolina K., Wong V.,
RA Stagljar I., Luescher B., Levenson R.;
RT "Effect of C-Terminal S-Palmitoylation on D2 Dopamine Receptor Trafficking
RT and Stability.";
RL PLoS ONE 10:e0140661-e0140661(2015).
RN [13]
RP VARIANT [LARGE SCALE ANALYSIS] SER-104.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Palmitoyltransferase that could catalyze the addition of
CC palmitate onto protein substrates including the D(2) dopamine receptor
CC DRD2. {ECO:0000269|PubMed:26535572}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC EC=2.3.1.225; Evidence={ECO:0000305|PubMed:26535572};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684;
CC Evidence={ECO:0000305|PubMed:26535572};
CC -!- INTERACTION:
CC Q9NPG8; Q9NY35: CLDND1; NbExp=3; IntAct=EBI-20009624, EBI-4319704;
CC Q9NPG8; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-20009624, EBI-11988865;
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:21926431}; Multi-pass membrane protein
CC {ECO:0000305|PubMed:21926431}. Golgi apparatus membrane
CC {ECO:0000269|PubMed:26535572}; Multi-pass membrane protein
CC {ECO:0000305|PubMed:21926431}. Cell membrane
CC {ECO:0000269|PubMed:26535572}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- DOMAIN: The C-terminal di-lysine motif confers endoplasmic reticulum
CC localization. {ECO:0000269|PubMed:21926431}.
CC -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC {ECO:0000250|UniProtKB:Q8IUH5}.
CC -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC {ECO:0000305}.
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DR EMBL; AF201931; AAF86867.1; -; mRNA.
DR EMBL; AL136674; CAB66609.1; -; mRNA.
DR EMBL; AY359090; AAQ89448.1; -; mRNA.
DR EMBL; CR533511; CAG38542.1; -; mRNA.
DR EMBL; AK001341; BAA91636.1; -; mRNA.
DR EMBL; AK223532; BAD97252.1; -; mRNA.
DR EMBL; AC079742; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH236963; EAL23725.1; -; Genomic_DNA.
DR EMBL; CH878731; EAW55023.1; -; Genomic_DNA.
DR EMBL; BC001239; AAH01239.1; -; mRNA.
DR CCDS; CCDS5352.1; -.
DR RefSeq; NP_001127859.1; NM_001134387.1.
DR RefSeq; NP_001127860.1; NM_001134388.1.
DR RefSeq; NP_001127861.1; NM_001134389.1.
DR RefSeq; NP_060576.1; NM_018106.3.
DR RefSeq; XP_005249850.1; XM_005249793.2.
DR RefSeq; XP_005249851.1; XM_005249794.3.
DR RefSeq; XP_005249852.1; XM_005249795.2.
DR RefSeq; XP_005249853.1; XM_005249796.3.
DR AlphaFoldDB; Q9NPG8; -.
DR BioGRID; 120449; 9.
DR IntAct; Q9NPG8; 3.
DR MINT; Q9NPG8; -.
DR STRING; 9606.ENSP00000379934; -.
DR iPTMnet; Q9NPG8; -.
DR PhosphoSitePlus; Q9NPG8; -.
DR SwissPalm; Q9NPG8; -.
DR BioMuta; ZDHHC4; -.
DR DMDM; 28202108; -.
DR EPD; Q9NPG8; -.
DR jPOST; Q9NPG8; -.
DR MassIVE; Q9NPG8; -.
DR MaxQB; Q9NPG8; -.
DR PaxDb; Q9NPG8; -.
DR PeptideAtlas; Q9NPG8; -.
DR PRIDE; Q9NPG8; -.
DR ProteomicsDB; 81994; -.
DR Antibodypedia; 24908; 53 antibodies from 15 providers.
DR DNASU; 55146; -.
DR Ensembl; ENST00000335965.11; ENSP00000337475.6; ENSG00000136247.15.
DR Ensembl; ENST00000396706.2; ENSP00000379934.2; ENSG00000136247.15.
DR Ensembl; ENST00000396707.6; ENSP00000379935.2; ENSG00000136247.15.
DR Ensembl; ENST00000396709.5; ENSP00000379937.1; ENSG00000136247.15.
DR Ensembl; ENST00000396713.6; ENSP00000379941.2; ENSG00000136247.15.
DR Ensembl; ENST00000405731.7; ENSP00000385027.3; ENSG00000136247.15.
DR GeneID; 55146; -.
DR KEGG; hsa:55146; -.
DR MANE-Select; ENST00000335965.11; ENSP00000337475.6; NM_001134389.2; NP_001127861.1.
DR UCSC; uc003sqh.4; human.
DR CTD; 55146; -.
DR DisGeNET; 55146; -.
DR GeneCards; ZDHHC4; -.
DR HGNC; HGNC:18471; ZDHHC4.
DR HPA; ENSG00000136247; Low tissue specificity.
DR neXtProt; NX_Q9NPG8; -.
DR OpenTargets; ENSG00000136247; -.
DR PharmGKB; PA38337; -.
DR VEuPathDB; HostDB:ENSG00000136247; -.
DR eggNOG; KOG1312; Eukaryota.
DR GeneTree; ENSGT00920000149163; -.
DR HOGENOM; CLU_042181_4_0_1; -.
DR InParanoid; Q9NPG8; -.
DR OMA; QHCPLVA; -.
DR OrthoDB; 445686at2759; -.
DR PhylomeDB; Q9NPG8; -.
DR TreeFam; TF330931; -.
DR BRENDA; 2.3.1.225; 2681.
DR PathwayCommons; Q9NPG8; -.
DR SignaLink; Q9NPG8; -.
DR BioGRID-ORCS; 55146; 9 hits in 1083 CRISPR screens.
DR ChiTaRS; ZDHHC4; human.
DR GeneWiki; ZDHHC4; -.
DR GenomeRNAi; 55146; -.
DR Pharos; Q9NPG8; Tdark.
DR PRO; PR:Q9NPG8; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q9NPG8; protein.
DR Bgee; ENSG00000136247; Expressed in left testis and 174 other tissues.
DR ExpressionAtlas; Q9NPG8; baseline and differential.
DR Genevisible; Q9NPG8; HS.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IBA:GO_Central.
DR GO; GO:0018230; P:peptidyl-L-cysteine S-palmitoylation; IBA:GO_Central.
DR GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR Pfam; PF01529; DHHC; 1.
DR PROSITE; PS50216; DHHC; 1.
PE 1: Evidence at protein level;
KW Acyltransferase; Cell membrane; Endoplasmic reticulum; Golgi apparatus;
KW Lipoprotein; Membrane; Palmitate; Reference proteome; Transferase;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..344
FT /note="Palmitoyltransferase ZDHHC4"
FT /id="PRO_0000212865"
FT TOPO_DOM 1..2
FT /note="Lumenal"
FT /evidence="ECO:0000305|PubMed:21926431"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 24..67
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:21926431"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..99
FT /note="Lumenal"
FT /evidence="ECO:0000305|PubMed:21926431"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..192
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:21926431"
FT TRANSMEM 193..213
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 214..255
FT /note="Lumenal"
FT /evidence="ECO:0000305|PubMed:21926431"
FT TRANSMEM 256..276
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 277..344
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:21926431"
FT DOMAIN 149..199
FT /note="DHHC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00067"
FT MOTIF 341..344
FT /note="Di-lysine motif"
FT /evidence="ECO:0000269|PubMed:21926431"
FT ACT_SITE 179
FT /note="S-palmitoyl cysteine intermediate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00067"
FT VARIANT 53
FT /note="V -> M (in dbSNP:rs11559146)"
FT /evidence="ECO:0000269|Ref.6"
FT /id="VAR_023832"
FT VARIANT 104
FT /note="P -> S (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036260"
FT MUTAGEN 340
FT /note="R->A: Does not affect localization to the
FT endoplasmic reticulum."
FT /evidence="ECO:0000269|PubMed:21926431"
FT MUTAGEN 341
FT /note="K->A: Does not affect localization to the
FT endoplasmic reticulum."
FT /evidence="ECO:0000269|PubMed:21926431"
FT MUTAGEN 342
FT /note="K->A: Impaired localization to the endoplasmic
FT reticulum."
FT /evidence="ECO:0000269|PubMed:21926431"
FT CONFLICT 33
FT /note="L -> P (in Ref. 6; BAD97252)"
FT /evidence="ECO:0000305"
FT CONFLICT 244
FT /note="F -> I (in Ref. 2; CAB66609 and 4; CAG38542)"
FT /evidence="ECO:0000305"
FT CONFLICT 276
FT /note="F -> S (in Ref. 2; CAB66609 and 4; CAG38542)"
FT /evidence="ECO:0000305"
FT CONFLICT 294
FT /note="D -> V (in Ref. 2; CAB66609 and 4; CAG38542)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 344 AA; 39787 MW; 3D2CF22B14036908 CRC64;
MDFLVLFLFY LASVLMGLVL ICVCSKTHSL KGLARGGAQI FSCIIPECLQ RAVHGLLHYL
FHTRNHTFIV LHLVLQGMVY TEYTWEVFGY CQELELSLHY LLLPYLLLGV NLFFFTLTCG
TNPGIITKAN ELLFLHVYEF DEVMFPKNVR CSTCDLRKPA RSKHCSVCNW CVHRFDHHCV
WVNNCIGAWN IRYFLIYVLT LTASAATVAI VSTTFLVHLV VMSDLYQETY IDDLGHLHVM
DTVFLIQYLF LTFPRIVFML GFVVVLSFLL GGYLLFVLYL AATNQTTNEW YRGDWAWCQR
CPLVAWPPSA EPQVHRNIHS HGLRSNLQEI FLPAFPCHER KKQE
