ZDHC5_DICDI
ID ZDHC5_DICDI Reviewed; 751 AA.
AC Q554E7; Q8SSY4;
DT 14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Putative ZDHHC-type palmitoyltransferase 5;
DE EC=2.3.1.225;
DE AltName: Full=Zinc finger DHHC domain-containing protein 5;
GN ORFNames=DDB_G0275097;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2] {ECO:0000305, ECO:0000312|EMBL:EAL69829.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000312|EMBL:EAL69829.1};
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Palmitoyl acyltransferase. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC EC=2.3.1.225;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC {ECO:0000250|UniProtKB:Q8IUH5}.
CC -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC {ECO:0000255}.
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DR EMBL; AAFI02000013; EAL69829.1; -; Genomic_DNA.
DR RefSeq; XP_643764.1; XM_638672.1.
DR AlphaFoldDB; Q554E7; -.
DR SMR; Q554E7; -.
DR STRING; 44689.DDB0167467; -.
DR PaxDb; Q554E7; -.
DR EnsemblProtists; EAL69829; EAL69829; DDB_G0275097.
DR GeneID; 8619809; -.
DR KEGG; ddi:DDB_G0275097; -.
DR dictyBase; DDB_G0275097; -.
DR eggNOG; KOG0509; Eukaryota.
DR HOGENOM; CLU_370656_0_0_1; -.
DR InParanoid; Q554E7; -.
DR OMA; DVPDCNG; -.
DR PhylomeDB; Q554E7; -.
DR PRO; PR:Q554E7; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016409; F:palmitoyltransferase activity; IBA:GO_Central.
DR GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0018345; P:protein palmitoylation; IBA:GO_Central.
DR Gene3D; 1.25.40.20; -; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF01529; DHHC; 1.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50216; DHHC; 1.
PE 3: Inferred from homology;
KW Acyltransferase; ANK repeat; Glycoprotein; Lipoprotein; Membrane;
KW Palmitate; Reference proteome; Repeat; Transferase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..751
FT /note="Putative ZDHHC-type palmitoyltransferase 5"
FT /id="PRO_0000259994"
FT TRANSMEM 385..405
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 421..440
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 446..469
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 548..568
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 597..617
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 159..188
FT /note="ANK 1"
FT /evidence="ECO:0000255"
FT REPEAT 193..222
FT /note="ANK 2"
FT /evidence="ECO:0000255"
FT REPEAT 226..255
FT /note="ANK 3"
FT /evidence="ECO:0000255"
FT REPEAT 260..289
FT /note="ANK 4"
FT /evidence="ECO:0000255"
FT REPEAT 293..322
FT /note="ANK 5"
FT /evidence="ECO:0000255"
FT REPEAT 330..359
FT /note="ANK 6"
FT /evidence="ECO:0000255"
FT DOMAIN 504..554
FT /note="DHHC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00067"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 641..711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..703
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 534
FT /note="S-palmitoyl cysteine intermediate"
FT /evidence="ECO:0000250"
FT CARBOHYD 161
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 626
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 656
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 751 AA; 85829 MW; 733ED7C6CCF060C5 CRC64;
MIPTQTPPRQ QMMNHNHQPQ QIQQPQQIQP HQPQQQQPHQ FRPLDENAEI PFLQIVTPNQ
MIKLPPMFQE QYKQLLNRWS NQCIKKSGLL YTQAVPYNQV LVLLEIAKNG DIQEYRDFIQ
VIIESNQNKD GDENEESIQQ QQQQQQLTLK SIINLIDLEG NTSIHYAIMR KNKAMVSYLI
DCGANLDIQN LEEGHTPLHW ACIKADSSFV LQLVENGADI HLTDKRGYNA LLHAAQYNEV
NSVRYLIEKG LDPVQCKDIQ LHTAVHWTSF QGHANMARYF ISLGVDPNAQ DIQGRTAFHW
GCIKGHKQVV SMLCSFEGQD SIDKTIRDND GKTAYQLAES KEHYEIIDYL DTKLKDDKLF
GGNERLYHRF WTVMGVLTVL VPTWILCYVP VIFGLPLLAV GGYFLKNYLH LNYWVPERNN
WLLPSILYSS VSIWYLIYLL RIAPLVMAIN IFPNLIINAT SWYFFYFFIR LTKEDPGTIS
KHISKEKSNE NFMNALSSGR QIPLICPTCL INRPIRSKHC PSCKGCFARF DHHCVWINKC
IGINNQALFI TVLFSYVILV ISGFIVTWDY FKSDSNAPIL SESYIQSFLF YYTNYPFILL
FSIYGIGMAI WIGKLAISQV LTILFNKTTY EQIQQIREFE SRQGHGHSHG GDQQCNHSHG
SGGGDHGHSH GGSSGSGSGS GSGDHGHSHG GQPSLPSSSG GSKKDSDKSF HNQQTNFDMY
HRGVVNNVKE FLFDSQKFYF QTENIYADSR V
