CC170_HUMAN
ID CC170_HUMAN Reviewed; 715 AA.
AC Q8IYT3; Q5VXB7; Q6P9E4; Q96KA9; Q9H5M3;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 3.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Coiled-coil domain-containing protein 170 {ECO:0000305};
GN Name=CCDC170 {ECO:0000312|HGNC:HGNC:21177}; Synonyms=C6orf97;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS SER-324; ILE-604 AND
RP ILE-683.
RC TISSUE=Colon, and Embryo;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS THR-331 AND ILE-683.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, AND MICROTUBULES-BINDING.
RX PubMed=28687497; DOI=10.1016/j.ebiom.2017.06.024;
RA Jiang P., Li Y., Poleshko A., Medvedeva V., Baulina N., Zhang Y., Zhou Y.,
RA Slater C.M., Pellegrin T., Wasserman J., Lindy M., Efimov A., Daly M.,
RA Katz R.A., Chen X.;
RT "The Protein Encoded by the CCDC170 Breast Cancer Gene Functions to
RT Organize the Golgi-Microtubule Network.";
RL EBioMedicine 22:28-43(2017).
CC -!- FUNCTION: Plays a role in Golgi-associated microtubules organization
CC and stabilization. {ECO:0000269|PubMed:28687497}.
CC -!- SUBUNIT: Binds Golgi-associated microtubules.
CC {ECO:0000269|PubMed:28687497}.
CC -!- INTERACTION:
CC Q8IYT3; P51946: CCNH; NbExp=3; IntAct=EBI-2808089, EBI-741406;
CC Q8IYT3; Q96I25: RBM17; NbExp=3; IntAct=EBI-2808089, EBI-740272;
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:28687497}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB55025.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK026958; BAB15602.1; -; mRNA.
DR EMBL; AK027300; BAB55025.1; ALT_INIT; mRNA.
DR EMBL; AL359494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL590543; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC060803; AAH60803.1; -; mRNA.
DR CCDS; CCDS43515.1; -.
DR RefSeq; NP_079335.2; NM_025059.3.
DR AlphaFoldDB; Q8IYT3; -.
DR SMR; Q8IYT3; -.
DR BioGRID; 123130; 24.
DR IntAct; Q8IYT3; 7.
DR STRING; 9606.ENSP00000239374; -.
DR iPTMnet; Q8IYT3; -.
DR PhosphoSitePlus; Q8IYT3; -.
DR BioMuta; CCDC170; -.
DR DMDM; 117949395; -.
DR EPD; Q8IYT3; -.
DR MassIVE; Q8IYT3; -.
DR PaxDb; Q8IYT3; -.
DR PeptideAtlas; Q8IYT3; -.
DR PRIDE; Q8IYT3; -.
DR ProteomicsDB; 71234; -.
DR Antibodypedia; 54824; 113 antibodies from 21 providers.
DR DNASU; 80129; -.
DR Ensembl; ENST00000239374.8; ENSP00000239374.6; ENSG00000120262.10.
DR GeneID; 80129; -.
DR KEGG; hsa:80129; -.
DR MANE-Select; ENST00000239374.8; ENSP00000239374.6; NM_025059.4; NP_079335.2.
DR UCSC; uc003qol.4; human.
DR CTD; 80129; -.
DR DisGeNET; 80129; -.
DR GeneCards; CCDC170; -.
DR HGNC; HGNC:21177; CCDC170.
DR HPA; ENSG00000120262; Tissue enriched (fallopian).
DR neXtProt; NX_Q8IYT3; -.
DR OpenTargets; ENSG00000120262; -.
DR PharmGKB; PA134876442; -.
DR VEuPathDB; HostDB:ENSG00000120262; -.
DR eggNOG; ENOG502QRTF; Eukaryota.
DR GeneTree; ENSGT00390000012924; -.
DR HOGENOM; CLU_014559_0_0_1; -.
DR InParanoid; Q8IYT3; -.
DR OMA; ENAFMKG; -.
DR OrthoDB; 357429at2759; -.
DR PhylomeDB; Q8IYT3; -.
DR TreeFam; TF325112; -.
DR PathwayCommons; Q8IYT3; -.
DR SignaLink; Q8IYT3; -.
DR BioGRID-ORCS; 80129; 4 hits in 1066 CRISPR screens.
DR ChiTaRS; CCDC170; human.
DR GenomeRNAi; 80129; -.
DR Pharos; Q8IYT3; Tbio.
DR PRO; PR:Q8IYT3; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q8IYT3; protein.
DR Bgee; ENSG00000120262; Expressed in bronchial epithelial cell and 126 other tissues.
DR Genevisible; Q8IYT3; HS.
DR GO; GO:0036064; C:ciliary basal body; IDA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
DR GO; GO:0008017; F:microtubule binding; IDA:UniProtKB.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IDA:UniProtKB.
DR InterPro; IPR039139; CCDC170-like.
DR PANTHER; PTHR18863; PTHR18863; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Golgi apparatus; Reference proteome.
FT CHAIN 1..715
FT /note="Coiled-coil domain-containing protein 170"
FT /id="PRO_0000255256"
FT REGION 355..591
FT /note="Required for binding to microtubules and Golgi
FT apparatus location"
FT /evidence="ECO:0000269|PubMed:28687497"
FT COILED 30..286
FT /evidence="ECO:0000255"
FT COILED 360..418
FT /evidence="ECO:0000255"
FT COILED 478..656
FT /evidence="ECO:0000255"
FT VARIANT 269
FT /note="A -> V (in dbSNP:rs12205837)"
FT /id="VAR_028856"
FT VARIANT 324
FT /note="F -> S (in dbSNP:rs953767)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_028857"
FT VARIANT 331
FT /note="A -> T (in dbSNP:rs17855718)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_028858"
FT VARIANT 345
FT /note="E -> K (in dbSNP:rs55868409)"
FT /id="VAR_061591"
FT VARIANT 479
FT /note="N -> K (in dbSNP:rs35159094)"
FT /id="VAR_050805"
FT VARIANT 553
FT /note="R -> Q (in dbSNP:rs34430497)"
FT /id="VAR_050806"
FT VARIANT 604
FT /note="V -> I (in dbSNP:rs6929137)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_028859"
FT VARIANT 683
FT /note="V -> I (in dbSNP:rs3734804)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_028860"
FT CONFLICT 456
FT /note="M -> T (in Ref. 1; BAB15602)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 715 AA; 82277 MW; B2A332347E0FD1D9 CRC64;
MSLDCTSHIA LGAASPAPEE TYDHLSEVPV TREQLNHYRN VAQNARSELA ATLVKFECAQ
SELQDLRSKM LSKEVSCQEL KAEMESYKEN NARKSSLLTS LRDRVQELEE ESAALSTSKI
RTEITAHAAI KENQELKKKV VELNEKLQKC SKENEENKKQ VSKNCRKHEE FLTQLRDCLD
PDERNDKASD EDLILKLRDL RKENEFVKGQ IVILEETINV HEMEAKASRE TIMRLASEVN
REQKKAASCT EEKEKLNQDL LSAVEAKEAL EREVKIFQER LLAGQQVWDA SKQEVSLLKK
SSSELEKSLK ASQDAVTTSQ SQYFSFREKI AALLRGRLSM TGSTEDTILE KIREMDSREE
SRDRMVSQLE AQISELVEQL GKESGFHQKA LQRAQKAENM LETLQGQLTH LEAELVSGGV
LRDNLNFEKQ KYLKFLDQLS QKMKLDQMAA ELGFDMRLDV VLARTEQLVR LESNAVIENK
TIAHNLQRKL KTQKERLESK ELHMSLLRQK IAQLEEEKQA RTALVVERDN AHLTIRNLQK
KVERLQKELN TCRDLHTELK AKLADTNELK IKTLEQTKAI EDLNKSRDQL EKMKEKAEKK
LMSVKSELDT TEHEAKENKE RARNMIEVVT SEMKTLKKSL EEAEKREKQL ADFREVVSQM
LGLNVTSLAL PDYEIIKCLE RLVHSHQHHF VTCACLKDVT TGQERHPQGH LQLLH
