ZDS1_SCHPO
ID ZDS1_SCHPO Reviewed; 938 AA.
AC O14100;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Protein zds1;
DE AltName: Full=Meiotically up-regulated gene 88 protein;
GN Name=zds1; Synonyms=mug88; ORFNames=SPAC31F12.01, SPAC637.14;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION IN MEIOSIS.
RX PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA Smith G.R., Moreno S.;
RT "A large-scale screen in S. pombe identifies seven novel genes required for
RT critical meiotic events.";
RL Curr. Biol. 15:2056-2062(2005).
RN [3]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=16322512; DOI=10.1534/genetics.105.050906;
RA Yakura M., Ozoe F., Ishida H., Nakagawa T., Tanaka K., Matsuda H.,
RA Kawamukai M.;
RT "zds1, a novel gene encoding an ortholog of Zds1 and Zds2, controls sexual
RT differentiation, cell wall integrity and cell morphology in fission
RT yeast.";
RL Genetics 172:811-825(2006).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Has a role in establishing cell polarity. Also required for
CC maintenance of cell wall integrity, sexual differentiation, calcium
CC tolerance and cell morphology. Involved in Ras-MAPK signaling pathway
CC at cell cortex. Has a role in meiosis. {ECO:0000269|PubMed:16303567,
CC ECO:0000269|PubMed:16322512}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16322512,
CC ECO:0000269|PubMed:16823372}. Note=Localizes to the septum and cell
CC cortex.
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DR EMBL; CU329670; CAA22593.1; -; Genomic_DNA.
DR PIR; T38616; T38616.
DR PIR; T39006; T39006.
DR RefSeq; NP_594632.1; NM_001020060.2.
DR AlphaFoldDB; O14100; -.
DR BioGRID; 279619; 72.
DR STRING; 4896.SPAC31F12.01.1; -.
DR iPTMnet; O14100; -.
DR MaxQB; O14100; -.
DR PaxDb; O14100; -.
DR PRIDE; O14100; -.
DR EnsemblFungi; SPAC31F12.01.1; SPAC31F12.01.1:pep; SPAC31F12.01.
DR GeneID; 2543190; -.
DR KEGG; spo:SPAC31F12.01; -.
DR PomBase; SPAC31F12.01; zds1.
DR VEuPathDB; FungiDB:SPAC31F12.01; -.
DR eggNOG; ENOG502RC08; Eukaryota.
DR HOGENOM; CLU_312642_0_0_1; -.
DR InParanoid; O14100; -.
DR OMA; QYEMQHR; -.
DR PhylomeDB; O14100; -.
DR PRO; PR:O14100; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005938; C:cell cortex; IDA:PomBase.
DR GO; GO:0032153; C:cell division site; HDA:PomBase.
DR GO; GO:0030428; C:cell septum; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0000935; C:division septum; IDA:PomBase.
DR GO; GO:0019888; F:protein phosphatase regulator activity; ISO:PomBase.
DR GO; GO:0030437; P:ascospore formation; IGI:PomBase.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0071277; P:cellular response to calcium ion; IMP:PomBase.
DR GO; GO:0030010; P:establishment of cell polarity; IBA:GO_Central.
DR GO; GO:0071852; P:fungal-type cell wall organization or biogenesis; IMP:PomBase.
DR GO; GO:0010971; P:positive regulation of G2/M transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; NAS:PomBase.
DR InterPro; IPR040206; Zds1/2.
DR InterPro; IPR013941; ZDS1_C.
DR PANTHER; PTHR28089; PTHR28089; 2.
DR Pfam; PF08632; Zds_C; 1.
DR SMART; SM01327; Zds_C; 1.
PE 1: Evidence at protein level;
KW Cell wall biogenesis/degradation; Cytoplasm; Meiosis; Reference proteome.
FT CHAIN 1..938
FT /note="Protein zds1"
FT /id="PRO_0000249236"
FT REGION 1..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 326..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 424..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..60
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..559
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 586..610
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..682
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 683..715
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..738
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 771..785
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 938 AA; 103098 MW; 6E20EF9A8A16149A CRC64;
MSSSSVSNTL SIETKSDPKD PAFVASQEST ECNEHDTTQL SGSSSEPLEN NSSLTRSTDD
PSVEIRSKLV SPDNEANLLS DQNITISNEN NNENDTTEEA ETSSGNEAAD DEDSSSDAQS
SVPSFSEIHD GMSEEELDKE RKTLTHLRRI SLQGADDPEI PTDWSVAMSP PETEQDASTL
FWVPANLHPE LNPTGWKSFL DLQVKNLKSP TATDTSSSPL EHIRSLRRRK SLLSRQVKAD
DAVINYQDGS PIVEKAYLKR HRSLRLNELE HLESLARDPH RMVSLVDGMS NGSPEDSPLL
VSPNHFLQRS SRTTIRRTGA SIRTIHRGKT STLSGNRSHS ILQKPTDTSP LHKIEPISAD
ELVESDDSRT SALSNSQNPS DDVENQSDQA LEVLSLTNPP KIDNASADTT LHKETNKIDK
LYVSENKAES AVASESSLSE GTLALKAPAP ENKPEKSSTS KPPVPENKAE DSVVLKSSVP
EDKSENSIAS KPSATEGIPE NAIALQSSVP ENKAEDSVVL KSSVPEDKSE DSVPSKSSVL
EDKHENSVEI DKKADDSLPS NNKTEGYTPS VVREEKNYSE PNASPSVIPP RVPTPVPGRT
LSPKPTRIPT PIPSSLNVSL ESSKKPEIFH ERHIPTPETG PNKPSKNNIL KSTQVPVTPK
QKSSTANKGS TSSPSPPSSE SKKTKRSWGR LFVSGDSDKE HKEHKKDKQK KKNDQISSSS
KSASSFKKDR DKESIFGSLF GSKKKQTEIP PVSSSPPHND APPKAKPISA PSELPNTTSV
AEAKCQTVTD DEGTDQQSDE KSTEPKTFIP DKDYYWSRFP ICTERAIYRL SHIKLSNAHR
PLFQQVLLSN FMYSYLDLIS RISSNRPMNN VQQSTAKPIR KDINGQQRRS EFSAENVKNE
LENLSYQFGD QRKRNLNRKG STIHTVSQNI QKVSKNAK
