CC171_MOUSE
ID CC171_MOUSE Reviewed; 1324 AA.
AC E9Q1U1; Q8BLX2;
DT 16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 1.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Coiled-coil domain-containing protein 171;
GN Name=Ccdc171;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-368 (ISOFORMS 1/2).
RC STRAIN=C57BL/6J; TISSUE=Aorta, and Vein;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=E9Q1U1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=E9Q1U1-2; Sequence=VSP_043769;
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DR EMBL; AL928772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX682545; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX936355; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR405712; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK041005; BAC30777.1; -; mRNA.
DR CCDS; CCDS89772.1; -. [E9Q1U1-2]
DR RefSeq; NP_001074481.1; NM_001081012.1.
DR RefSeq; XP_006538051.1; XM_006537988.3.
DR RefSeq; XP_006538052.1; XM_006537989.3. [E9Q1U1-2]
DR AlphaFoldDB; E9Q1U1; -.
DR SMR; E9Q1U1; -.
DR STRING; 10090.ENSMUSP00000056520; -.
DR PhosphoSitePlus; E9Q1U1; -.
DR MaxQB; E9Q1U1; -.
DR PaxDb; E9Q1U1; -.
DR PRIDE; E9Q1U1; -.
DR ProteomicsDB; 283715; -. [E9Q1U1-1]
DR ProteomicsDB; 283716; -. [E9Q1U1-2]
DR Antibodypedia; 10105; 56 antibodies from 9 providers.
DR Ensembl; ENSMUST00000053414; ENSMUSP00000056520; ENSMUSG00000052407. [E9Q1U1-1]
DR Ensembl; ENSMUST00000231339; ENSMUSP00000155912; ENSMUSG00000052407. [E9Q1U1-2]
DR GeneID; 320226; -.
DR UCSC; uc008tlc.1; mouse. [E9Q1U1-1]
DR CTD; 203238; -.
DR MGI; MGI:1922152; Ccdc171.
DR VEuPathDB; HostDB:ENSMUSG00000052407; -.
DR eggNOG; ENOG502QT2H; Eukaryota.
DR GeneTree; ENSGT00390000007924; -.
DR HOGENOM; CLU_007506_0_0_1; -.
DR InParanoid; E9Q1U1; -.
DR OMA; CRRFECD; -.
DR OrthoDB; 333370at2759; -.
DR PhylomeDB; E9Q1U1; -.
DR TreeFam; TF330625; -.
DR BioGRID-ORCS; 320226; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Ccdc171; mouse.
DR PRO; PR:E9Q1U1; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; E9Q1U1; protein.
DR Bgee; ENSMUSG00000052407; Expressed in animal zygote and 82 other tissues.
DR ExpressionAtlas; E9Q1U1; baseline and differential.
DR Genevisible; E9Q1U1; MM.
DR InterPro; IPR038820; CCDC171.
DR PANTHER; PTHR47899; PTHR47899; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..1324
FT /note="Coiled-coil domain-containing protein 171"
FT /id="PRO_0000417502"
FT REGION 1301..1324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 29..296
FT /evidence="ECO:0000255"
FT COILED 325..393
FT /evidence="ECO:0000255"
FT COILED 453..521
FT /evidence="ECO:0000255"
FT COILED 599..712
FT /evidence="ECO:0000255"
FT COILED 981..1145
FT /evidence="ECO:0000255"
FT VAR_SEQ 477
FT /note="E -> ELNNINDAK (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_043769"
SQ SEQUENCE 1324 AA; 152309 MW; 105B10058B286777 CRC64;
MSLNTSSNAT PGDTQRLKNA SLDVKQMLKN ETESDIIADL RKKLHRAKKE KLEMTTKHNA
ELSSYESQIA RLRSEVEKGE ALRQRLEYDL AVARKEAGLG RRAAEERLAE AQRIQERLCA
QNSELQGKAN EIEKTFQISQ EKWREECRRF EHDLEERDNI IQNCNQEYES LMQEKTRLQK
TLQEILEKHE QEKTELESRV RETALGEFRL QTEEWEAERR ELQLIVQEQD SAVQSMQKKV
EQLEAEHMDC SDLLRRQTSE LEFSTQREER LRKEFEATTL RVRKLEENIE AERAAHLESK
FNSEIIQLRI RDLEGALQVE KASQAEAVAD LEMIKNEFKE VESAYEREKQ NTQESCAKLN
LLEREYFSQN KKLNEEIEDQ KKVIIDLSKR LQYNEKSCGE LQEELVMAKK HQAFLVETCE
NNVRELESIL GSFSVSAQWT SGVHKDKDKP PSFSVVLETL RRTLTDYQNK LEDASNEEKT
SNELDSTKQK IETHIKNTKE LQDKLTEVHK ELSHLRAKCA DREALITSLK VELQNVLHCW
EKEKACAAQC ESELQKLSQA FQKDSEEKLT FLHTLYQHLV AGCVLIKQPE GMLDKFSWSE
LCAVLQENVD ALIADLNRAN EKISHLEYIC KNKSDTMREL QQTQEDTFNK VAEQIKAQES
CWQKQKKELE FQYSELLLEV QRRAQKFQEI AEKNSEKLNR IETSHEQLVR ENSHFKTTLS
RTQREQTCLL AACALMAGAL CPLYSRSCAL STQRDFLQEQ VNSLELFKLE IRTLAQALSA
VDEKKQEEAK TKKKTFKGLV RVFRKGVIAI LAANRLKLLG QSCAFLFTWM ESCKEGIGML
VCTGEPKDKR QFPKHQREQL RCLQALAWLT SSDLLGTVIS SMTELQEVIS KTDPNSRICG
HLLIGAAKNS FAKLMDKLSS AMASIPLHSS RSITYVEKDS LVQRLARGLH KVNTLALKYG
LCSHIPIMKS TAALQKQIFG FTQRLHAAEV ERRSLRLEVT EYKRTVHEMK KELDKSQSLQ
TQLNEFKHSK LITHEKFESA CEELNNALLR EQQAQMLLNE QAQQLQELNY RLELHSSEEA
DKNQTLGEAV KSLSEAKMEL RRKDQSLRQL NRHLTQLEQD KRRLEENIRD AESALRMAAK
DKECVANHMR TIENMLHKVR DQISLSRTAA TRNDFTLQLP KLHLETFAME GLQGGPEVVA
CQAMIKSFMD VYQLASARIS TLEKEMTSHR SHIATLKSEL HTACLRENES LQSMGSRDHS
NLSVPSRAAA PMDTVGDLLP LQAELDTTYT FLKETFVNTA PHSLSSQSSP GVPTNAKRPS
QIGL
