ID   ZDS_NOSS1               Reviewed;         479 AA.
AC   Q9R6X4;
DT   02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2002, sequence version 2.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Zeta-carotene desaturase;
DE            EC=1.3.5.6;
DE   AltName: Full=9,9'-di-cis-zeta-carotene desaturase;
DE   AltName: Full=Carotene 7,8-desaturase;
GN   Name=crtQ; OrderedLocusNames=all2382;
OS   Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX   NCBI_TaxID=103690;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Mann V., Hirschberg J.;
RT   "Evolution of the carotenoid biosynthesis pathway: two pathways for
RT   lycopene synthesis exist in Anabaena PCC7120.";
RL   Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7120 / SAG 25.82 / UTEX 2576;
RX   PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA   Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A.,
RA   Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M.,
RA   Takazawa M., Yamada M., Yasuda M., Tabata S.;
RT   "Complete genomic sequence of the filamentous nitrogen-fixing
RT   cyanobacterium Anabaena sp. strain PCC 7120.";
RL   DNA Res. 8:205-213(2001).
CC   -!- FUNCTION: Catalyzes the conversion of zeta-carotene to lycopene via the
CC       intermediary of neurosporene. It carries out two consecutive
CC       desaturations (introduction of double bonds) at positions C-7 and C-7'
CC       (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=9,9'-di-cis-zeta-carotene + 2 a quinone = 7,7',9,9'-tetra-cis-
CC         lycopene + 2 a quinol; Xref=Rhea:RHEA:30955, ChEBI:CHEBI:24646,
CC         ChEBI:CHEBI:48716, ChEBI:CHEBI:62466, ChEBI:CHEBI:132124; EC=1.3.5.6;
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000305};
CC       Name=NADP(+); Xref=ChEBI:CHEBI:58349; Evidence={ECO:0000305};
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000305};
CC   -!- PATHWAY: Carotenoid biosynthesis; lycopene biosynthesis.
CC   -!- SIMILARITY: Belongs to the zeta carotene desaturase family.
CC       {ECO:0000305}.
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DR   EMBL; Y15115; CAB56041.1; -; Genomic_DNA.
DR   EMBL; BA000019; BAB74081.1; -; Genomic_DNA.
DR   PIR; AG2103; AG2103.
DR   RefSeq; WP_010996538.1; NZ_RSCN01000002.1.
DR   AlphaFoldDB; Q9R6X4; -.
DR   SMR; Q9R6X4; -.
DR   STRING; 103690.17131474; -.
DR   EnsemblBacteria; BAB74081; BAB74081; BAB74081.
DR   KEGG; ana:all2382; -.
DR   eggNOG; COG3349; Bacteria.
DR   OMA; MLTIFMM; -.
DR   OrthoDB; 630753at2; -.
DR   BioCyc; MetaCyc:MON-20345; -.
DR   UniPathway; UPA00803; -.
DR   Proteomes; UP000002483; Chromosome.
DR   GO; GO:0052887; F:7,9,9'-tricis-neurosporene:quinone oxidoreductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052886; F:9,9'-dicis-carotene:quinone oxidoreductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016719; F:carotene 7,8-desaturase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016117; P:carotenoid biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.50.50.60; -; 2.
DR   InterPro; IPR002937; Amino_oxidase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR014103; Zeta_caro_desat.
DR   Pfam; PF01593; Amino_oxidase; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR02732; zeta_caro_desat; 1.
PE   3: Inferred from homology;
KW   Carotenoid biosynthesis; FAD; Flavoprotein; NAD; Oxidoreductase;
KW   Reference proteome.
FT   CHAIN           1..479
FT                   /note="Zeta-carotene desaturase"
FT                   /id="PRO_0000217856"
FT   CONFLICT        92..94
FT                   /note="Missing (in Ref. 1)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   479 AA;  53579 MW;  D8B14BD09B965F01 CRC64;
     MRVAIVGAGL AGLATAIDLA DAGCEVQIFE SRPFVGGKVG SWIDGDGNHV EMGLHVFFGC
     YYQLFELMNK VGAFSHLRLK EHTHTFVNKG GRTGALDFRF FTGAPFNGLK AFFTTSQLSL
     QDKLQNAIAL GTSPIVRGLV DFEGAMKTIR NLDKISFADW FRSHGGSNGS IKRMWNPIAY
     ALGFIDCENI SARCMLTIFQ FFAVRSEASV LRMLEGSPDE YLHQPILRYL EARGTKVYTR
     RQVREIKYAE AEGQTRVTGI VVAKGDEVEE ITADAYVCAC DIPGIQRVLP QEWRKWSEFD
     NIYKLDAVPV ATVQMRFDGW VTELQDENKR KQLKEAAGLD NLLYTADADF SCFADLALTS
     PSDYYRQGQG SLLQLVLTPG DPFIKESNEA IAQHVLKQVY ELFPSSRELN MTWYSVVKLA
     QSLYREAPGM DVYRPNQKTP IANFFLAGSY TQQDYIDSME GATVSGRRAA KVILDNIKK