ID   ZDS_SOLLC               Reviewed;         588 AA.
AC   Q9SE20;
DT   02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Zeta-carotene desaturase, chloroplastic/chromoplastic;
DE            EC=1.3.5.6;
DE   AltName: Full=9,9'-di-cis-zeta-carotene desaturase;
DE   AltName: Full=Carotene 7,8-desaturase;
DE   Flags: Precursor;
GN   Name=ZDS;
OS   Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC   Solanum subgen. Lycopersicon.
OX   NCBI_TaxID=4081;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Bartley G.E., Ishida B.K.;
RT   "Zeta-carotene desaturase from tomato.";
RL   (er) Plant Gene Register PGR99-181(1999).
CC   -!- FUNCTION: Catalyzes the conversion of zeta-carotene to lycopene via the
CC       intermediary of neurosporene. It carries out two consecutive
CC       desaturations (introduction of double bonds) at positions C-7 and C-7'.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=9,9'-di-cis-zeta-carotene + 2 a quinone = 7,7',9,9'-tetra-cis-
CC         lycopene + 2 a quinol; Xref=Rhea:RHEA:30955, ChEBI:CHEBI:24646,
CC         ChEBI:CHEBI:48716, ChEBI:CHEBI:62466, ChEBI:CHEBI:132124; EC=1.3.5.6;
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000305};
CC       Name=NADP(+); Xref=ChEBI:CHEBI:58349; Evidence={ECO:0000305};
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000305};
CC   -!- PATHWAY: Carotenoid biosynthesis; lycopene biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast. Plastid, chromoplast.
CC   -!- SIMILARITY: Belongs to the zeta carotene desaturase family.
CC       {ECO:0000305}.
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DR   EMBL; AF195507; AAF13698.1; -; mRNA.
DR   RefSeq; NP_001234383.2; NM_001247454.2.
DR   AlphaFoldDB; Q9SE20; -.
DR   SMR; Q9SE20; -.
DR   STRING; 4081.Solyc01g097810.2.1; -.
DR   PaxDb; Q9SE20; -.
DR   PRIDE; Q9SE20; -.
DR   GeneID; 543629; -.
DR   KEGG; sly:543629; -.
DR   eggNOG; KOG0029; Eukaryota.
DR   InParanoid; Q9SE20; -.
DR   OrthoDB; 1151887at2759; -.
DR   BRENDA; 1.3.5.6; 3101.
DR   UniPathway; UPA00803; -.
DR   Proteomes; UP000004994; Unplaced.
DR   ExpressionAtlas; Q9SE20; baseline and differential.
DR   GO; GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell.
DR   GO; GO:0009509; C:chromoplast; IEA:UniProtKB-SubCell.
DR   GO; GO:0052887; F:7,9,9'-tricis-neurosporene:quinone oxidoreductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052886; F:9,9'-dicis-carotene:quinone oxidoreductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016719; F:carotene 7,8-desaturase activity; IBA:GO_Central.
DR   GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR   GO; GO:0016120; P:carotene biosynthetic process; IBA:GO_Central.
DR   GO; GO:0016117; P:carotenoid biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.50.50.60; -; 1.
DR   InterPro; IPR002937; Amino_oxidase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR014103; Zeta_caro_desat.
DR   Pfam; PF01593; Amino_oxidase; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR02732; zeta_caro_desat; 1.
PE   2: Evidence at transcript level;
KW   Carotenoid biosynthesis; Chloroplast; Chromoplast; FAD; Flavoprotein; NAD;
KW   Oxidoreductase; Plastid; Reference proteome; Transit peptide.
FT   TRANSIT         1..?
FT                   /note="Chloroplast and chromoplast"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..588
FT                   /note="Zeta-carotene desaturase,
FT                   chloroplastic/chromoplastic"
FT                   /id="PRO_0000041607"
SQ   SEQUENCE   588 AA;  64733 MW;  786675800C11B846 CRC64;
     MATSSAYLSC PATSATGKKH VFPNGSPGFL VFGGTRLSNR LVTRKSVIRA DLDSMVSDMS
     TNAPKGLFPP EPEHYRGPKL KVAIIGAGLA GMSTAVELLD QGHEVDIYES RTFIGGKVGS
     FVDRRGNHIE MGLHVFFGCY NNLFRLLKKV GAEKNLLVKE HTHTFVNKGG EIGELDFRFP
     VGAPLHGINA FLSTNQLKIY DKARNAVALA LSPVVRALVD PDGALQQIRD LDNVSFSEWF
     LSKGGTRASI QRMWDPVAYA LGFIDCDNMS ARCMLTIFAL FATKTEASLL RMLKGSPDVY
     LSGPIKKYIM DKGGRFHLRW GCREVLYETS SDGSMYVSGL AMSKATQKKI VKADAYVAAC
     DVPGIKRLVP QKWRELEFFD NIYKLVGVPV VTVQLRYNGW VTELQDLERS RQLKRAAGLD
     NLLYTPDADF SCFADLALAS PDDYYIEGQG SLLQCVLTPG DPYMPLSNDE IIKRVTKQVL
     ALFPSSQGLE VTWSSVLKIG QSLYREGPGK DPFRPDQKTP VENFFLAGSY TKQDYIDSME
     GATLSGRQAS AYICNVGEQL MALRKKITAA ELNDISKGVS LSDELSLV