ZEAU_MAIZE
ID ZEAU_MAIZE Reviewed; 266 AA.
AC O48966;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=22 kDa alpha-zein 4 {ECO:0000303|PubMed:11691845};
DE AltName: Full=22 kDa alpha-zein PZ22.3 {ECO:0000305};
DE AltName: Full=22kD alpha-zein 3 {ECO:0000303|PubMed:11595803};
DE AltName: Full=Zein-alpha PZ22.3 {ECO:0000312|EMBL:AFW60330.1};
DE Flags: Precursor;
GN Name=AZS22-4 {ECO:0000303|PubMed:11691845};
GN Synonyms=AZ22Z3 {ECO:0000303|PubMed:11595803};
GN ORFNames=ZEAMMB73_535631 {ECO:0000312|EMBL:AFW60330.1};
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577 {ECO:0000312|EMBL:AAC01573.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11691845; DOI=10.1101/gr.197301;
RA Song R., Llaca V., Linton E., Messing J.;
RT "Sequence, regulation, and evolution of the maize 22-kD alpha zein gene
RT family.";
RL Genome Res. 11:1817-1825(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=cv. B73; TISSUE=Endosperm;
RX PubMed=11595803; DOI=10.2307/3871509;
RA Woo Y.M., Hu D.W., Larkins B.A., Jung R.;
RT "Genomics analysis of genes expressed in maize endosperm identifies novel
RT seed proteins and clarifies patterns of zein gene expression.";
RL Plant Cell 13:2297-2317(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. B73;
RX PubMed=19965430; DOI=10.1126/science.1178534;
RA Schnable P.S., Ware D., Fulton R.S., Stein J.C., Wei F., Pasternak S.,
RA Liang C., Zhang J., Fulton L., Graves T.A., Minx P., Reily A.D.,
RA Courtney L., Kruchowski S.S., Tomlinson C., Strong C., Delehaunty K.,
RA Fronick C., Courtney B., Rock S.M., Belter E., Du F., Kim K., Abbott R.M.,
RA Cotton M., Levy A., Marchetto P., Ochoa K., Jackson S.M., Gillam B.,
RA Chen W., Yan L., Higginbotham J., Cardenas M., Waligorski J., Applebaum E.,
RA Phelps L., Falcone J., Kanchi K., Thane T., Scimone A., Thane N., Henke J.,
RA Wang T., Ruppert J., Shah N., Rotter K., Hodges J., Ingenthron E.,
RA Cordes M., Kohlberg S., Sgro J., Delgado B., Mead K., Chinwalla A.,
RA Leonard S., Crouse K., Collura K., Kudrna D., Currie J., He R.,
RA Angelova A., Rajasekar S., Mueller T., Lomeli R., Scara G., Ko A.,
RA Delaney K., Wissotski M., Lopez G., Campos D., Braidotti M., Ashley E.,
RA Golser W., Kim H., Lee S., Lin J., Dujmic Z., Kim W., Talag J., Zuccolo A.,
RA Fan C., Sebastian A., Kramer M., Spiegel L., Nascimento L., Zutavern T.,
RA Miller B., Ambroise C., Muller S., Spooner W., Narechania A., Ren L.,
RA Wei S., Kumari S., Faga B., Levy M.J., McMahan L., Van Buren P.,
RA Vaughn M.W., Ying K., Yeh C.-T., Emrich S.J., Jia Y., Kalyanaraman A.,
RA Hsia A.-P., Barbazuk W.B., Baucom R.S., Brutnell T.P., Carpita N.C.,
RA Chaparro C., Chia J.-M., Deragon J.-M., Estill J.C., Fu Y., Jeddeloh J.A.,
RA Han Y., Lee H., Li P., Lisch D.R., Liu S., Liu Z., Nagel D.H., McCann M.C.,
RA SanMiguel P., Myers A.M., Nettleton D., Nguyen J., Penning B.W.,
RA Ponnala L., Schneider K.L., Schwartz D.C., Sharma A., Soderlund C.,
RA Springer N.M., Sun Q., Wang H., Waterman M., Westerman R., Wolfgruber T.K.,
RA Yang L., Yu Y., Zhang L., Zhou S., Zhu Q., Bennetzen J.L., Dawe R.K.,
RA Jiang J., Jiang N., Presting G.G., Wessler S.R., Aluru S.,
RA Martienssen R.A., Clifton S.W., McCombie W.R., Wing R.A., Wilson R.K.;
RT "The B73 maize genome: complexity, diversity, and dynamics.";
RL Science 326:1112-1115(2009).
RN [4]
RP INTERACTION WITH OP10.
RX PubMed=27541862; DOI=10.1371/journal.pgen.1006270;
RA Yao D., Qi W., Li X., Yang Q., Yan S., Ling H., Wang G., Wang G., Song R.;
RT "Maize opaque10 encodes a cereal-specific protein that is essential for the
RT proper distribution of zeins in endosperm protein bodies.";
RL PLoS Genet. 12:E1006270-E1006270(2016).
CC -!- FUNCTION: Zeins are major seed storage proteins.
CC {ECO:0000305|PubMed:11691845}.
CC -!- SUBUNIT: Interacts with OP10 (via N-terminus).
CC {ECO:0000269|PubMed:27541862}.
CC -!- TISSUE SPECIFICITY: Expressed in endosperm, mainly in the peripheral
CC regions. {ECO:0000269|PubMed:11595803}.
CC -!- MISCELLANEOUS: The alpha zeins of 19 kDa and 22 kDa account for 70% of
CC the total zein fraction. They are encoded by a large multigene family.
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: Structurally, 22K and 19K zeins are composed of nine
CC adjacent, topologically antiparallel helices clustered within a
CC distorted cylinder. {ECO:0000250|UniProtKB:P04698}.
CC -!- SIMILARITY: Belongs to the zein family. {ECO:0000305}.
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DR EMBL; AF031569; AAC01573.1; -; Genomic_DNA.
DR EMBL; AF371275; AAL16990.1; -; mRNA.
DR EMBL; CM000780; AFW60330.1; -; Genomic_DNA.
DR PIR; T01323; T01323.
DR RefSeq; NP_001105058.1; NM_001111588.2.
DR AlphaFoldDB; O48966; -.
DR STRING; 4577.GRMZM2G044625_P01; -.
DR PaxDb; O48966; -.
DR GeneID; 541925; -.
DR KEGG; zma:541925; -.
DR eggNOG; ENOG502R48M; Eukaryota.
DR HOGENOM; CLU_073697_0_0_1; -.
DR OMA; VANAPTY; -.
DR OrthoDB; 1842808at2759; -.
DR Proteomes; UP000007305; Chromosome 4.
DR ExpressionAtlas; O48966; baseline and differential.
DR GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
DR InterPro; IPR002530; Zein.
DR Pfam; PF01559; Zein; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Seed storage protein; Signal; Storage protein.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..266
FT /note="22 kDa alpha-zein 4"
FT /evidence="ECO:0000255"
FT /id="PRO_5007696878"
SQ SEQUENCE 266 AA; 28867 MW; 346B929193C4E734 CRC64;
MATKILSLLA LLALFASATN AFIIPQCSLA PSSIITQFLP PVTSMGFEHP AVQAYRLQQA
IAASVLQQPI SQLQQQSLAH LTIQTIATQQ QQQFLPALSH LAMVNPAAYL QQQLLASNPL
ALANVVANQP QQQLQQFLPA LSQLAMVNPA AYLQQQQLLS SSPLAVANAP TYLQQQLLQQ
IVPALTQLVV ANPAAYLQQL LPFNQLTMSN SAAYLQQRQQ LLNPLAVANP LVAAFLQQQQ
LLPYNQFSLI NPVLSRQQPI VGGAIF
