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CC172_MOUSE
ID   CC172_MOUSE             Reviewed;         267 AA.
AC   Q810N9; Q9DAG3;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Coiled-coil domain-containing protein 172;
DE   AltName: Full=TEKT2-binding protein 2 {ECO:0000303|PubMed:24394471};
GN   Name=Ccdc172; Synonyms=Tekt2bp1 {ECO:0000303|PubMed:24394471};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   SUBCELLULAR LOCATION, AND INTERACTION WITH TEKT2.
RX   PubMed=24394471; DOI=10.1369/0022155413520607;
RA   Yamaguchi A., Kaneko T., Inai T., Iida H.;
RT   "Molecular cloning and subcellular localization of Tektin2-binding protein
RT   1 (Ccdc 172) in rat spermatozoa.";
RL   J. Histochem. Cytochem. 62:286-297(2014).
CC   -!- SUBUNIT: May interact with TEKT2. {ECO:0000269|PubMed:24394471}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24394471}. Cell
CC       projection, cilium {ECO:0000250|UniProtKB:Q6AXT4}. Note=In caput
CC       spermatozoa, localized in the middle piece, predominantly concentrated
CC       at the mitochondrial sheath of the flagella and to a lesser extent with
CC       outer dense fibers (ODF) (By similarity). Colocalized with TEKT2 at the
CC       perinuclear region (PubMed:24394471). {ECO:0000250|UniProtKB:Q6AXT4,
CC       ECO:0000269|PubMed:24394471}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q810N9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q810N9-2; Sequence=VSP_034843;
CC   -!- SIMILARITY: Belongs to the CCDC172 family. {ECO:0000305}.
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DR   EMBL; AK005864; BAB24284.1; -; mRNA.
DR   EMBL; BC049707; AAH49707.1; -; mRNA.
DR   CCDS; CCDS38029.1; -. [Q810N9-1]
DR   RefSeq; NP_083648.1; NM_029372.2. [Q810N9-1]
DR   RefSeq; XP_006527487.1; XM_006527424.1.
DR   AlphaFoldDB; Q810N9; -.
DR   SMR; Q810N9; -.
DR   STRING; 10090.ENSMUSP00000068972; -.
DR   iPTMnet; Q810N9; -.
DR   PhosphoSitePlus; Q810N9; -.
DR   PaxDb; Q810N9; -.
DR   PRIDE; Q810N9; -.
DR   Antibodypedia; 46242; 46 antibodies from 10 providers.
DR   DNASU; 75645; -.
DR   Ensembl; ENSMUST00000069419; ENSMUSP00000068972; ENSMUSG00000025090. [Q810N9-1]
DR   Ensembl; ENSMUST00000235305; ENSMUSP00000158558; ENSMUSG00000025090. [Q810N9-2]
DR   GeneID; 75645; -.
DR   KEGG; mmu:75645; -.
DR   UCSC; uc008iao.1; mouse. [Q810N9-1]
DR   UCSC; uc012bnz.1; mouse. [Q810N9-2]
DR   CTD; 374355; -.
DR   MGI; MGI:1922895; Ccdc172.
DR   VEuPathDB; HostDB:ENSMUSG00000025090; -.
DR   eggNOG; ENOG502RZCX; Eukaryota.
DR   GeneTree; ENSGT00390000005203; -.
DR   HOGENOM; CLU_094609_0_0_1; -.
DR   InParanoid; Q810N9; -.
DR   OMA; LEMHKEG; -.
DR   OrthoDB; 1399070at2759; -.
DR   PhylomeDB; Q810N9; -.
DR   TreeFam; TF333231; -.
DR   BioGRID-ORCS; 75645; 3 hits in 72 CRISPR screens.
DR   ChiTaRS; Ccdc172; mouse.
DR   PRO; PR:Q810N9; -.
DR   Proteomes; UP000000589; Chromosome 19.
DR   RNAct; Q810N9; protein.
DR   Bgee; ENSMUSG00000025090; Expressed in spermatocyte and 28 other tissues.
DR   Genevisible; Q810N9; MM.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0097225; C:sperm midpiece; ISS:UniProtKB.
DR   InterPro; IPR029618; CCDC172.
DR   PANTHER; PTHR22419; PTHR22419; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell projection; Coiled coil; Cytoplasm;
KW   Reference proteome.
FT   CHAIN           1..267
FT                   /note="Coiled-coil domain-containing protein 172"
FT                   /id="PRO_0000344514"
FT   COILED          24..97
FT                   /evidence="ECO:0000255"
FT   COILED          128..191
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         150..217
FT                   /note="EMKSVERNRGQLWELQKLKNELLQELFTLQKKLKVLKDEETEAICITKQLEA
FT                   EKTKVRDKPQHDPECV -> D (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_034843"
SQ   SEQUENCE   267 AA;  31483 MW;  1F5898E92FC2E034 CRC64;
     MSLESLFQHI IFSEHQAEES RRVMREVRSE ITRCRGKIKK ATEDLSEEKI KLESKVQQLS
     EKSFLLELLK THENALERQL SEIISERDTL LQACEAIKNK TTEEEERFIK EITDFNDNYE
     ITKKRDTLMK ENIEMEMADL DSQADVLRRE MKSVERNRGQ LWELQKLKNE LLQELFTLQK
     KLKVLKDEET EAICITKQLE AEKTKVRDKP QHDPECVRLK RELDLYKAED MESVYRALQA
     EVDLLELALA PKDPQDSNSL SHEPPHT
 
 
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