ID   CC172_RAT               Reviewed;         263 AA.
AC   Q6AXT4;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Coiled-coil domain-containing protein 172;
DE   AltName: Full=TEKT2-binding protein 1 {ECO:0000303|PubMed:24394471};
GN   Name=Ccdc172; Synonyms=Tekt2bp1 {ECO:0000303|PubMed:24394471};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX   PubMed=24394471; DOI=10.1369/0022155413520607;
RA   Yamaguchi A., Kaneko T., Inai T., Iida H.;
RT   "Molecular cloning and subcellular localization of Tektin2-binding protein
RT   1 (Ccdc 172) in rat spermatozoa.";
RL   J. Histochem. Cytochem. 62:286-297(2014).
CC   -!- SUBUNIT: May interact with TEKT2. {ECO:0000250|UniProtKB:Q810N9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q810N9}. Cell
CC       projection, cilium {ECO:0000269|PubMed:24394471}. Note=In caput
CC       spermatozoa, localized in the middle piece, but predominantly
CC       concentrated at the mitochondrial sheath of the flagella and to a
CC       lesser extent with outer dense fibers (ODF). Colocalized with TEKT2 at
CC       the perinuclear region (By similarity). {ECO:0000250|UniProtKB:Q810N9,
CC       ECO:0000269|PubMed:24394471}.
CC   -!- TISSUE SPECIFICITY: Detected in spermatozoa (at protein level).
CC       Predominantly expressed in testis and in spermatozoa from the caput and
CC       corpus epididymis. {ECO:0000269|PubMed:24394471}.
CC   -!- DEVELOPMENTAL STAGE: Increased after 3 weeks of postnatal development.
CC       {ECO:0000269|PubMed:24394471}.
CC   -!- SIMILARITY: Belongs to the CCDC172 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC079324; AAH79324.1; -; mRNA.
DR   RefSeq; NP_001014191.1; NM_001014169.2.
DR   AlphaFoldDB; Q6AXT4; -.
DR   SMR; Q6AXT4; -.
DR   STRING; 10116.ENSRNOP00000029328; -.
DR   PaxDb; Q6AXT4; -.
DR   Ensembl; ENSRNOT00000036012; ENSRNOP00000029328; ENSRNOG00000017656.
DR   GeneID; 361776; -.
DR   KEGG; rno:361776; -.
DR   CTD; 374355; -.
DR   RGD; 1359412; Ccdc172.
DR   eggNOG; ENOG502RZCX; Eukaryota.
DR   GeneTree; ENSGT00390000005203; -.
DR   HOGENOM; CLU_094609_0_0_1; -.
DR   InParanoid; Q6AXT4; -.
DR   OMA; LEMHKEG; -.
DR   OrthoDB; 1399070at2759; -.
DR   PhylomeDB; Q6AXT4; -.
DR   TreeFam; TF333231; -.
DR   PRO; PR:Q6AXT4; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000017656; Expressed in testis and 1 other tissue.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0097225; C:sperm midpiece; IDA:UniProtKB.
DR   InterPro; IPR029618; CCDC172.
DR   PANTHER; PTHR22419; PTHR22419; 1.
PE   1: Evidence at protein level;
KW   Cell projection; Coiled coil; Cytoplasm; Reference proteome.
FT   CHAIN           1..263
FT                   /note="Coiled-coil domain-containing protein 172"
FT                   /id="PRO_0000344515"
FT   COILED          13..191
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   263 AA;  31075 MW;  21BB4556F6881A62 CRC64;
     MSLESLFQHI IFTEHQAEES RRVMREVRSE IARCRGKIKK ATEDLNEEKI KLESKVQQFS
     EKTFLLELLK TRENALERQC SAIVSERDRL LQACEAIKKK TTEQEERFIK EITDFNDNYE
     ITKKRDALME EDIKLEMADL ENQAEALRGE MKSMEYNSGQ LQELQKLKSE LLQELFTLQK
     KLKVLKDEET EAICITKHLE AEKIKIREKP QHDPECVRRL KRELDLYKEE DMESVCRALQ
     IEVDLLESTL VPKDPQDNNS LSR