ZEB2_GIBZE
ID ZEB2_GIBZE Reviewed; 332 AA.
AC I1RFC6; Q2VLJ0;
DT 18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2012, sequence version 1.
DT 25-MAY-2022, entry version 50.
DE RecName: Full=Transcription factor ZEB2 {ECO:0000303|PubMed:16262793};
DE AltName: Full=Zearalenone biosynthesis protein 2 {ECO:0000303|PubMed:16262793};
GN Name=ZEB2 {ECO:0000303|PubMed:16262793};
GN ORFNames=FGRAMPH1_01T05755, FGSG_02398;
OS Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=229533;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, DISRUPTION PHENOTYPE, AND
RP INDUCTION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=16262793; DOI=10.1111/j.1365-2958.2005.04884.x;
RA Kim Y.T., Lee Y.R., Jin J., Han K.H., Kim H., Kim J.C., Lee T., Yun S.H.,
RA Lee Y.W.;
RT "Two different polyketide synthase genes are required for synthesis of
RT zearalenone in Gibberella zeae.";
RL Mol. Microbiol. 58:1102-1113(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA King R., Urban M., Hammond-Kosack M.C.U., Hassani-Pak K.,
RA Hammond-Kosack K.E.;
RT "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT graminearum.";
RL BMC Genomics 16:544-544(2015).
CC -!- FUNCTION: Transcription factor that specifically controls transcription
CC of the zearalenone biosynthesis cluster genes (PubMed:16262793).
CC {ECO:0000269|PubMed:16262793}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC -!- INDUCTION: Conditions for carbon-, nitrogen-, or phosphorus-starvations
CC lead to very low expression (PubMed:16262793). Increase in pH results
CC in gradual reduction of the gene expression (PubMed:16262793).
CC {ECO:0000269|PubMed:16262793}.
CC -!- DISRUPTION PHENOTYPE: Impairs the expression of the zearalenone
CC biosynthesis cluster genes and results in the loss of beta-zearalenonol
CC and zearalenone production (PubMed:16262793).
CC {ECO:0000269|PubMed:16262793}.
CC -!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
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DR EMBL; DQ019316; ABB90285.1; -; Genomic_DNA.
DR EMBL; DS231663; ESU07828.1; -; Genomic_DNA.
DR EMBL; HG970332; CEF74682.1; -; Genomic_DNA.
DR RefSeq; XP_011318313.1; XM_011320011.1.
DR AlphaFoldDB; I1RFC6; -.
DR SMR; I1RFC6; -.
DR EnsemblFungi; ESU07828; ESU07828; FGSG_02398.
DR GeneID; 23549776; -.
DR KEGG; fgr:FGSG_02398; -.
DR VEuPathDB; FungiDB:FGRAMPH1_01G05755; -.
DR eggNOG; ENOG502T2FU; Eukaryota.
DR HOGENOM; CLU_836908_0_0_1; -.
DR InParanoid; I1RFC6; -.
DR PHI-base; PHI:1321; -.
DR PHI-base; PHI:715; -.
DR Proteomes; UP000070720; Chromosome 1.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0106150; P:zearalenone biosynthetic process; IMP:GO_Central.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..332
FT /note="Transcription factor ZEB2"
FT /id="PRO_0000438786"
FT DOMAIN 17..50
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 21..43
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 45..52
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 106..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 332 AA; 37665 MW; 011807C16BCFA73F CRC64;
MQSTESFHAL PTRSDVEDPN ERRKIQNRIA QKKHRQKMKR RIEELETKVN NQCQTSNWTS
HAPTDSCQEQ QFLDNTDFGL MLEDDLLYRE LSASLDGAGL TAVAQMHDSP RPNQQQRLSV
SGMPSSPTST SNVAQRGLSI GDHSSASNHL SSLSLVPGST EGSLPTRQHD NLCNQDLRDM
VPEEKMSRIL KVIQDAGYKD MDSFMTEYYV RDFDASSHVS AVQRQSRSRR LRGFLEQLRV
GAESWSDYEA HDYQQEISKS AEAIYAKELD VFSTTTLGEN ASFQGLASLY RVLQSTVGSD
IENHLRHEQS MMQRQVSEIV HRQVYTFNPA QC
