ZEN1_DROME
ID ZEN1_DROME Reviewed; 353 AA.
AC P09089; Q0IGS3; Q9VI45;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1988, sequence version 1.
DT 03-AUG-2022, entry version 188.
DE RecName: Full=Protein zerknuellt 1;
DE Short=ZEN-1;
GN Name=zen; Synonyms=z1, zen1; ORFNames=CG1046;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=2892759; DOI=10.1101/gad.1.10.1268;
RA Rushlow C., Doyle H., Hoey T., Levine M.;
RT "Molecular characterization of the zerknullt region of the Antennapedia
RT gene complex in Drosophila.";
RL Genes Dev. 1:1268-1279(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Berkeley;
RA Celniker S.E., Pfeiffer B., Knafels J., Martin C.H., Mayeda C.A.,
RA Palazzolo M.J.;
RT "Complete sequence of the Antennapedia complex of Drosophila.";
RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Larva, and Pupae;
RA Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the differentiation of the dorsal-ventral
CC pattern, and does not appear to be involved in the process of
CC segmentation. {ECO:0000269|PubMed:2892759}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000269|PubMed:2892759}.
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DR EMBL; X68347; CAA48416.1; -; mRNA.
DR EMBL; AE001572; AAD19800.1; -; Genomic_DNA.
DR EMBL; AE014297; AAF54087.1; -; Genomic_DNA.
DR EMBL; BT028847; ABI34228.1; -; mRNA.
DR PIR; A43697; A43697.
DR RefSeq; NP_476793.1; NM_057445.3.
DR PDB; 1KZ2; NMR; -; A=132-147.
DR PDBsum; 1KZ2; -.
DR AlphaFoldDB; P09089; -.
DR SMR; P09089; -.
DR BioGRID; 66026; 19.
DR DIP; DIP-18255N; -.
DR IntAct; P09089; 7.
DR STRING; 7227.FBpp0081170; -.
DR PaxDb; P09089; -.
DR DNASU; 40828; -.
DR EnsemblMetazoa; FBtr0081670; FBpp0081170; FBgn0004053.
DR GeneID; 40828; -.
DR KEGG; dme:Dmel_CG1046; -.
DR CTD; 40828; -.
DR FlyBase; FBgn0004053; zen.
DR VEuPathDB; VectorBase:FBgn0004053; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000156043; -.
DR HOGENOM; CLU_817043_0_0_1; -.
DR InParanoid; P09089; -.
DR OMA; YYPVHQP; -.
DR OrthoDB; 858478at2759; -.
DR PhylomeDB; P09089; -.
DR SignaLink; P09089; -.
DR BioGRID-ORCS; 40828; 0 hits in 1 CRISPR screen.
DR EvolutionaryTrace; P09089; -.
DR GenomeRNAi; 40828; -.
DR PRO; PR:P09089; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0004053; Expressed in anlage in statu nascendi and 22 other tissues.
DR Genevisible; P09089; DM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:FlyBase.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:FlyBase.
DR GO; GO:0007378; P:amnioserosa formation; TAS:FlyBase.
DR GO; GO:0048749; P:compound eye development; IMP:FlyBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..353
FT /note="Protein zerknuellt 1"
FT /id="PRO_0000049112"
FT DNA_BIND 90..149
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 48..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 148..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 242..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 134..142
FT /evidence="ECO:0007829|PDB:1KZ2"
FT TURN 143..146
FT /evidence="ECO:0007829|PDB:1KZ2"
SQ SEQUENCE 353 AA; 39302 MW; 1FA64031C160CE2B CRC64;
MSSVMHYYPV HQAKVGSYSA DPSEVKYSDL IYGHHHDVNP IGLPPNYNQM NSNPTTLNDH
CSPQHVHQQH VSSDENLPSQ PNHDSQRVKL KRSRTAFTSV QLVELENEFK SNMYLYRTRR
IEIAQRLSLC ERQVKIWFQN RRMKFKKDIQ GHREPKSNAK LAQPQAEQSA HRGIVKRLMS
YSQDPREGTA AAEKRPMMAV APVNPKPDYQ ASQKMKTEAS TNNGMCSSAD LSEILEHLAQ
TTAAPQVSTA TSSTGTSTNS ASSSSSGHYS YNVDLVLQSI KQDLEAAAQA WSKSKSAPIL
ATQSWHPSSQ SQVPTSVHAA PSMNLSWGEP AAKSRKLSVN HMNPCVTSYN YPN
