ZEN2_DROME
ID ZEN2_DROME Reviewed; 252 AA.
AC P09090; Q9V3K6;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 2.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Protein zerknuellt 2;
DE Short=ZEN-2;
GN Name=zen2; Synonyms=z2; ORFNames=CG1048;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=2892759; DOI=10.1101/gad.1.10.1268;
RA Rushlow C., Doyle H., Hoey T., Levine M.;
RT "Molecular characterization of the zerknullt region of the Antennapedia
RT gene complex in Drosophila.";
RL Genes Dev. 1:1268-1279(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Berkeley;
RA Celniker S.E., Pfeiffer B., Knafels J., Martin C.H., Mayeda C.A.,
RA Palazzolo M.J.;
RT "Complete sequence of the Antennapedia complex of Drosophila.";
RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- FUNCTION: Required for the differentiation of the dorsal-ventral
CC pattern, and does not appear to be involved in the process of
CC segmentation. {ECO:0000269|PubMed:2892759}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000269|PubMed:2892759}.
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DR EMBL; X68348; CAA48417.1; -; mRNA.
DR EMBL; AE001572; AAD19801.1; -; Genomic_DNA.
DR EMBL; AE014297; AAF54088.1; -; Genomic_DNA.
DR PIR; B43697; B43697.
DR RefSeq; NP_476794.1; NM_057446.3.
DR AlphaFoldDB; P09090; -.
DR SMR; P09090; -.
DR STRING; 7227.FBpp0081171; -.
DR PaxDb; P09090; -.
DR DNASU; 40827; -.
DR EnsemblMetazoa; FBtr0081671; FBpp0081171; FBgn0004054.
DR GeneID; 40827; -.
DR KEGG; dme:Dmel_CG1048; -.
DR CTD; 40827; -.
DR FlyBase; FBgn0004054; zen2.
DR VEuPathDB; VectorBase:FBgn0004054; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000156043; -.
DR InParanoid; P09090; -.
DR OMA; YDYLQEF; -.
DR PhylomeDB; P09090; -.
DR BioGRID-ORCS; 40827; 0 hits in 1 CRISPR screen.
DR ChiTaRS; br; fly.
DR GenomeRNAi; 40827; -.
DR PRO; PR:P09090; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0004054; Expressed in ectoderm anlage and 8 other tissues.
DR ExpressionAtlas; P09090; differential.
DR Genevisible; P09090; DM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..252
FT /note="Protein zerknuellt 2"
FT /id="PRO_0000049113"
FT DNA_BIND 43..102
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT CONFLICT 27
FT /note="L -> F (in Ref. 1; CAA48417)"
FT /evidence="ECO:0000305"
FT CONFLICT 33
FT /note="P -> R (in Ref. 1; CAA48417)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 252 AA; 29027 MW; ABEA19B763F50868 CRC64;
MFAIQSENYF VDNYSVSDLM MYPCVELNVE AAPTATTRSS EKSKRSRTAF SSLQLIELER
EFHLNKYLAR TRRIEISQRL ALTERQVKIW FQNRRMKLKK STNRKGAIGA LTTSIPLSSQ
SSEDLQKDDQ IVERLLRYAN TNVETAPLRQ VDHGVLEEGQ ITPPYQSYDY LHEFSPEPMA
LPQLPFNEFD ANWASSWLGL EPTIPIAENV IEHNTQDQPM IQNFCWDSNS SSASSSDILD
VDYDFIQNLL NF
