ID   ZEN_DROSU               Reviewed;         373 AA.
AC   Q24648;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   29-SEP-2021, entry version 93.
DE   RecName: Full=Protein zerknuellt;
GN   Name=zen;
OS   Drosophila subobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7241;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=H271;
RX   PubMed=7587584; DOI=10.1007/bf00357688;
RA   Terol J., Perez-Alonso M., de Frutos R.;
RT   "Molecular characterization of the zerknullt region of the Antennapedia
RT   complex of D. subobscura.";
RL   Chromosoma 103:613-624(1995).
CC   -!- FUNCTION: Required for the differentiation of the dorsal-ventral
CC       pattern, and does not appear to be involved in the process of
CC       segmentation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
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DR   EMBL; X78058; CAA54976.1; -; Genomic_DNA.
DR   FlyBase; FBgn0015180; Dsub\zen.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..373
FT                   /note="Protein zerknuellt"
FT                   /id="PRO_0000049114"
FT   DNA_BIND        88..147
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          36..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          252..276
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   373 AA;  40604 MW;  7D647EA2241045F2 CRC64;
     MSSVMHYYPV HHPTAPPVVK YSDLLYGHHH SANLQPTSLQ NYTQHSVSSI PEHPSLQQHH
     HQHHQQQQLS SDENLPSQPS QDMQRVKLKR SRTAFTSVQL VELENEFKSN MYLYRTRRIE
     IAQRLSLCER QVKIWFQNRR MKFKKDIQGH REAKASAKLA QPQAEQSAHR GIVQRLMSYS
     QDPREAAASA AEKRPAVAAA PAAPVVAAPP VVAAATSTAS FYGQAKIKPQ AIPSNNNNSM
     CSSDLSEILE HLAQSTAXPA ATVTPPGPSI GPTCGSTGVS SSGHYSYNVD LVLQSIKQDL
     EAAAQAWSKS KAGPVLANAQ SWHPSGVGSS SVPAVSHATP SMNLSWGEPA AKSRKLSISH
     INPCVAGGYN YQN