ZEP1_ORYSJ
ID ZEP1_ORYSJ Reviewed; 869 AA.
AC Q7FAD5; A0A0N7KJ55; D4NYR7; Q0JCS1;
DT 04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT 04-MAR-2015, sequence version 2.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=Synaptonemal complex protein ZEP1 {ECO:0000305};
GN Name=ZEP1;
GN OrderedLocusNames=Os04g0452500 {ECO:0000312|EMBL:BAF14866.2},
GN LOC_Os04g37960 {ECO:0000305};
GN ORFNames=OSJNBa0027G07.1 {ECO:0000312|EMBL:CAE04367.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Nipponbare;
RX PubMed=20154151; DOI=10.1105/tpc.109.070789;
RA Wang M., Wang K., Tang D., Wei C., Li M., Shen Y., Chi Z., Gu M., Cheng Z.;
RT "The central element protein ZEP1 of the synaptonemal complex regulates the
RT number of crossovers during meiosis in rice.";
RL Plant Cell 22:417-430(2010).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12447439; DOI=10.1038/nature01183;
RA Feng Q., Zhang Y., Hao P., Wang S., Fu G., Huang Y., Li Y., Zhu J., Liu Y.,
RA Hu X., Jia P., Zhang Y., Zhao Q., Ying K., Yu S., Tang Y., Weng Q.,
RA Zhang L., Lu Y., Mu J., Lu Y., Zhang L.S., Yu Z., Fan D., Liu X., Lu T.,
RA Li C., Wu Y., Sun T., Lei H., Li T., Hu H., Guan J., Wu M., Zhang R.,
RA Zhou B., Chen Z., Chen L., Jin Z., Wang R., Yin H., Cai Z., Ren S., Lv G.,
RA Gu W., Zhu G., Tu Y., Jia J., Zhang Y., Chen J., Kang H., Chen X., Shao C.,
RA Sun Y., Hu Q., Zhang X., Zhang W., Wang L., Ding C., Sheng H., Gu J.,
RA Chen S., Ni L., Zhu F., Chen W., Lan L., Lai Y., Cheng Z., Gu M., Jiang J.,
RA Li J., Hong G., Xue Y., Han B.;
RT "Sequence and analysis of rice chromosome 4.";
RL Nature 420:316-320(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [6]
RP SUBCELLULAR LOCATION.
RX PubMed=22393242; DOI=10.1242/jcs.090993;
RA Shen Y., Tang D., Wang K., Wang M., Huang J., Luo W., Luo Q., Hong L.,
RA Li M., Cheng Z.;
RT "ZIP4 in homologous chromosome synapsis and crossover formation in rice
RT meiosis.";
RL J. Cell Sci. 125:2581-2591(2012).
RN [7]
RP INTERACTION WITH CRC1.
RX PubMed=23943860; DOI=10.1105/tpc.113.113175;
RA Miao C., Tang D., Zhang H., Wang M., Li Y., Tang S., Yu H., Gu M.,
RA Cheng Z.;
RT "Central region component1, a novel synaptonemal complex component, is
RT essential for meiotic recombination initiation in rice.";
RL Plant Cell 25:2998-3009(2013).
RN [8]
RP SUBCELLULAR LOCATION.
RX PubMed=27436711; DOI=10.1105/tpc.16.00108;
RA He Y., Wang C., Higgins J.D., Yu J., Zong J., Lu P., Zhang D., Liang W.;
RT "MEIOTIC F-BOX is essential for male meiotic DNA double-strand break repair
RT in rice.";
RL Plant Cell 28:1879-1893(2016).
CC -!- FUNCTION: Required for chromosome synapsis and regulates crossover
CC frequency during meiosis. Acts as transverse filament protein and
CC constitutes the central element of the synaptonemal complex.
CC {ECO:0000269|PubMed:20154151}.
CC -!- SUBUNIT: Interacts with CRC1. {ECO:0000269|PubMed:23943860}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20154151,
CC ECO:0000269|PubMed:22393242}. Chromosome {ECO:0000269|PubMed:20154151,
CC ECO:0000269|PubMed:22393242, ECO:0000269|PubMed:27436711}. Note=During
CC zygotene in meiocytes, initially localizes onto the chromosomes as
CC punctate foci and quickly extends into linear signals (PubMed:20154151,
CC PubMed:22393242). Associates with chromosomal axes at zygotene
CC (PubMed:27436711). {ECO:0000269|PubMed:20154151,
CC ECO:0000269|PubMed:22393242, ECO:0000269|PubMed:27436711}.
CC -!- TISSUE SPECIFICITY: Highly expressed in panicles.
CC {ECO:0000269|PubMed:20154151}.
CC -!- DISRUPTION PHENOTYPE: Decreased pollen fertility due to abnormal
CC synaptic behaviors and increased crossover formation during prophase I.
CC {ECO:0000269|PubMed:20154151}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAF14866.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAE04367.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; GU479042; ADD69817.1; -; mRNA.
DR EMBL; AL662937; CAE04367.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP008210; BAF14866.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014960; BAS89473.1; -; Genomic_DNA.
DR RefSeq; XP_015634514.1; XM_015779028.1.
DR AlphaFoldDB; Q7FAD5; -.
DR SMR; Q7FAD5; -.
DR STRING; 4530.OS04T0452500-00; -.
DR PRIDE; Q7FAD5; -.
DR EnsemblPlants; Os04t0452500-00; Os04t0452500-00; Os04g0452500.
DR GeneID; 4336010; -.
DR Gramene; Os04t0452500-00; Os04t0452500-00; Os04g0452500.
DR KEGG; osa:4336010; -.
DR eggNOG; ENOG502QSSX; Eukaryota.
DR HOGENOM; CLU_010415_0_0_1; -.
DR InParanoid; Q7FAD5; -.
DR OMA; KKQYDIM; -.
DR OrthoDB; 251210at2759; -.
DR Proteomes; UP000000763; Chromosome 4.
DR Proteomes; UP000059680; Chromosome 4.
DR GO; GO:0005694; C:chromosome; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0000802; C:transverse filament; IDA:UniProtKB.
DR GO; GO:0007129; P:homologous chromosome pairing at meiosis; IMP:UniProtKB.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IMP:UniProtKB.
PE 1: Evidence at protein level;
KW Chromosome; Coiled coil; Meiosis; Nucleus; Reference proteome.
FT CHAIN 1..869
FT /note="Synaptonemal complex protein ZEP1"
FT /id="PRO_0000432118"
FT REGION 841..869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 64..298
FT /evidence="ECO:0000255"
FT COILED 330..614
FT /evidence="ECO:0000255"
FT COILED 641..713
FT /evidence="ECO:0000255"
SQ SEQUENCE 869 AA; 100101 MW; CAF3F3BDF098DCF5 CRC64;
MQKLGLSGLR GLEGFRSLAG STSTAAKAPN PKPSSDIGGS TYGSFANLKI TAEKLVKEQA
SVKTDLEMTH TKLRRATEQI NLLEAKLQQA VNENAKLKVK QTEDSKLWQG LDSKVSSTKT
LCNQLTETLQ QLASQTERAE EDKKFFEEIL GKNSKAFEEF NCLLHDSSIK LECAEQMIIS
GKQEMLRIKQ EKEEMDQSYK EQLYASDTTI REKNSLIKQL EDSIEQNKAR LLYVDSRLEC
MEQELKLKED VCICLKENLA STESEKNDLK LRNEGYTLEV QKLSKDNKEL NELLSGFTVK
VTELDKEHTS ISSHVTQLIS SFERYDGKVH EEKMLMIKSA KDKFEHLQNQ YVNLISENNA
LQTEIEELKS RIIELQKTQE IVMVQHVEEC QVAEDKIRRL ESEAEISASN ISQLEKVASD
LEGRVQKLLE DSRSAENHKQ ELLQKILKLE SDNQELLGRV QSVLNEKSND TESLQGEIAK
RDQQVETLEN QVNQLCSIID EKEQLHTCAV EREKNLEEQK LQVQASLAAT ESQLTEAKKQ
YDIMLEGKKI ELSKHLKELS LKNDQAINEI RRKYELEKVE IINIEKEKAE KLIKEMENKC
NEKISENRQD SERYLMCLKE EHGSMVARIQ QDNEHKESTL RAYHKEELQR IQSQAENELR
ERLSSLRKDH EIQMKSLTKK HEENCQKLQD ELELQKSKEE KQRALLQLQW KVMGETQQVD
QEVNSKKEYS VSSIKRRDPY IRKEHQLQLV SPETKRKDVN LSGIIQSPIT NMLRKVEKGT
QDIPKHRKVT HHEYEVETAN GRITKRRKTK STVMFGEPNT QKSLHDTADK DPTKMKKVVA
GSHPHPANIG ELFSEGSLNP YAEDPYAFG
