ZEP2_MOUSE
ID ZEP2_MOUSE Reviewed; 2430 AA.
AC Q3UHF7; O55140; Q3UVD4; Q3UVH5;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Transcription factor HIVEP2;
DE AltName: Full=Human immunodeficiency virus type I enhancer-binding protein 2 homolog;
DE AltName: Full=Myc intron-binding protein 1;
DE Short=MIBP-1;
GN Name=Hivep2; Synonyms=Mibp1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TCF4, TISSUE
RP SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC TISSUE=Brain;
RX PubMed=10207097; DOI=10.1128/mcb.19.5.3736;
RA Doerflinger U., Pscherer A., Moser M., Ruemmele P., Schuele R.,
RA Buettner R.;
RT "Activation of somatostatin receptor II expression by transcription factors
RT MIBP1 and SEF-2 in the murine brain.";
RL Mol. Cell. Biol. 19:3736-3747(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, Cerebellum, and Urinary bladder;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-942; SER-947; SER-1040;
RP SER-1431; SER-1435; SER-2413 AND SER-2415, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Lung, Pancreas, and
RC Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which
CC is found in the enhancer elements of numerous viral promoters such as
CC those of SV40, CMV, or HIV1. In addition, related sequences are found
CC in the enhancer elements of a number of cellular promoters, including
CC those of the class I MHC, interleukin-2 receptor, somatostatin receptor
CC II, and interferon-beta genes. It may act in T-cell activation (By
CC similarity). {ECO:0000250, ECO:0000269|PubMed:10207097}.
CC -!- SUBUNIT: Interacts with TCF4. {ECO:0000269|PubMed:10207097}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Expressed in heart, lung, skeletal muscle and
CC liver. In the brain expressed in cerebral cortex, hippocampus, corpora
CC amygdala and cerebellar cortex. {ECO:0000269|PubMed:10207097}.
CC -!- DEVELOPMENTAL STAGE: At 13.5 dpc and 15.5 dpc expressed in anterior
CC neural tube over primordial frontal cortex, spinal cord, dorsal root
CC glanglia and developing skeletal muscle. {ECO:0000269|PubMed:10207097}.
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DR EMBL; Y15907; CAA75868.1; -; mRNA.
DR EMBL; AK137291; BAE23294.1; -; mRNA.
DR EMBL; AK137384; BAE23336.1; -; mRNA.
DR EMBL; AK147244; BAE27792.1; -; mRNA.
DR EMBL; AK147419; BAE27900.1; -; mRNA.
DR CCDS; CCDS23704.1; -.
DR RefSeq; NP_034567.2; NM_010437.2.
DR RefSeq; XP_006512619.1; XM_006512556.1.
DR RefSeq; XP_006512621.1; XM_006512558.2.
DR RefSeq; XP_006512622.1; XM_006512559.2.
DR RefSeq; XP_006512624.1; XM_006512561.3.
DR RefSeq; XP_011241431.1; XM_011243129.2.
DR RefSeq; XP_011241432.1; XM_011243130.2.
DR RefSeq; XP_011241433.1; XM_011243131.2.
DR RefSeq; XP_011241434.1; XM_011243132.2.
DR RefSeq; XP_011241435.1; XM_011243133.2.
DR RefSeq; XP_017169296.1; XM_017313807.1.
DR RefSeq; XP_017169297.1; XM_017313808.1.
DR RefSeq; XP_017169298.1; XM_017313809.1.
DR SMR; Q3UHF7; -.
DR BioGRID; 200314; 3.
DR IntAct; Q3UHF7; 1.
DR STRING; 10090.ENSMUSP00000015645; -.
DR iPTMnet; Q3UHF7; -.
DR PhosphoSitePlus; Q3UHF7; -.
DR EPD; Q3UHF7; -.
DR jPOST; Q3UHF7; -.
DR MaxQB; Q3UHF7; -.
DR PaxDb; Q3UHF7; -.
DR PRIDE; Q3UHF7; -.
DR ProteomicsDB; 274977; -.
DR Antibodypedia; 46676; 44 antibodies from 18 providers.
DR DNASU; 15273; -.
DR Ensembl; ENSMUST00000015645; ENSMUSP00000015645; ENSMUSG00000015501.
DR Ensembl; ENSMUST00000187083; ENSMUSP00000140290; ENSMUSG00000015501.
DR Ensembl; ENSMUST00000191138; ENSMUSP00000140150; ENSMUSG00000015501.
DR GeneID; 15273; -.
DR KEGG; mmu:15273; -.
DR UCSC; uc007elg.1; mouse.
DR CTD; 3097; -.
DR MGI; MGI:1338076; Hivep2.
DR VEuPathDB; HostDB:ENSMUSG00000015501; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000156512; -.
DR HOGENOM; CLU_000719_0_0_1; -.
DR InParanoid; Q3UHF7; -.
DR OMA; KYPIWKV; -.
DR OrthoDB; 212048at2759; -.
DR PhylomeDB; Q3UHF7; -.
DR TreeFam; TF331837; -.
DR BioGRID-ORCS; 15273; 7 hits in 74 CRISPR screens.
DR ChiTaRS; Hivep2; mouse.
DR PRO; PR:Q3UHF7; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q3UHF7; protein.
DR Bgee; ENSMUSG00000015501; Expressed in primary motor cortex and 253 other tissues.
DR ExpressionAtlas; Q3UHF7; baseline and differential.
DR Genevisible; Q3UHF7; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; TAS:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; TAS:MGI.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; TAS:MGI.
DR GO; GO:0006351; P:transcription, DNA-templated; TAS:MGI.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..2430
FT /note="Transcription factor HIVEP2"
FT /id="PRO_0000047372"
FT REPEAT 2037..2040
FT /note="1"
FT REPEAT 2043..2046
FT /note="2"
FT REPEAT 2055..2058
FT /note="3"
FT REPEAT 2067..2070
FT /note="4"
FT REPEAT 2073..2076
FT /note="5"
FT REPEAT 2090..2093
FT /note="6"
FT REPEAT 2096..2099
FT /note="7"
FT REPEAT 2102..2105
FT /note="8"
FT REPEAT 2114..2117
FT /note="9"
FT REPEAT 2129..2132
FT /note="10"
FT ZN_FING 189..211
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 217..239
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1783..1805
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1811..1835
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 744..995
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1472..1584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1848..1931
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1986..2117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2037..2132
FT /note="10 X 4 AA tandem repeats of S-P-[RGMKC]-[RK]"
FT REGION 2226..2252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2268..2309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2352..2430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 929..935
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 6..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..818
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 852..872
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 881..911
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 926..942
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 943..977
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 981..995
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1495..1519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1559..1575
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1858..1872
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1884..1908
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1914..1928
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1990..2005
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2010..2038
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2051..2095
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2269..2297
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2409..2430
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 811
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q00900"
FT MOD_RES 942
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 947
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1040
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1431
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1435
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 2102
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P31629"
FT MOD_RES 2281
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P31629"
FT MOD_RES 2285
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P31629"
FT MOD_RES 2413
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 2415
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 572
FT /note="G -> E (in Ref. 1; CAA75868)"
FT /evidence="ECO:0000305"
FT CONFLICT 661
FT /note="S -> P (in Ref. 1; CAA75868)"
FT /evidence="ECO:0000305"
FT CONFLICT 749
FT /note="D -> N (in Ref. 1; CAA75868)"
FT /evidence="ECO:0000305"
FT CONFLICT 762
FT /note="S -> G (in Ref. 1; CAA75868)"
FT /evidence="ECO:0000305"
FT CONFLICT 1112
FT /note="S -> P (in Ref. 1; CAA75868)"
FT /evidence="ECO:0000305"
FT CONFLICT 1211
FT /note="P -> S (in Ref. 1; CAA75868)"
FT /evidence="ECO:0000305"
FT CONFLICT 1223
FT /note="A -> G (in Ref. 1; CAA75868)"
FT /evidence="ECO:0000305"
FT CONFLICT 1496
FT /note="C -> S (in Ref. 1; CAA75868)"
FT /evidence="ECO:0000305"
FT CONFLICT 2001
FT /note="D -> E (in Ref. 2; BAE23294)"
FT /evidence="ECO:0000305"
FT CONFLICT 2091
FT /note="P -> A (in Ref. 1; CAA75868)"
FT /evidence="ECO:0000305"
FT CONFLICT 2122
FT /note="M -> L (in Ref. 1; CAA75868)"
FT /evidence="ECO:0000305"
FT CONFLICT 2263
FT /note="S -> C (in Ref. 2; BAE23336)"
FT /evidence="ECO:0000305"
FT CONFLICT 2294
FT /note="T -> A (in Ref. 2; BAE23294)"
FT /evidence="ECO:0000305"
FT CONFLICT 2314
FT /note="T -> A (in Ref. 1; CAA75868)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2430 AA; 266705 MW; 265694210C8A7024 CRC64;
MDTGDTALGQ KATSRSGETD SVSGRWRQEQ SAVLKMSTFS SQEGPRQPQI DPEQIGNAAS
AQLFGSGKLA SPGEGLHQVT EKQYPPHRPS PYPCQHSLSF PQHSLSQGMT HSHKPHQSLE
GPPWLFPGPL PSVASEDLFP FPMHGHSGGY PRKKISNLNP AYSQYSQKSI EQAEDAHKKE
HKPKKPGKYI CPYCSRACAK PSVLKKHIRS HTGERPYPCI PCGFSFKTKS NLYKHRKSHA
HAIKAGLVPF TESSVSKLDL EAGFIDVEAE IHSDGEQSTD TDEESSLFAE ASDKVSPGPP
VPLDIASRGG YHGSLEESLG GPMKVPILII PKSGIPLASE GSQYLSSEML PNPSLNAKAD
DSHTVKQKLA LRLSEKKGQD SEPSLNLLSP HSKGSTDSGY FSRSESAEQQ ISPPNTNAKS
YEEIIFGKYC RLSPRNTLSV TPTGQERTAM GRRGIMEPLP HLNTRLEVKM FEDPISQLNP
SKGEMDPGQI NMLKTTKFNS ECRQPQAIPS SVRNEGKPYP GNFLGSNPML LEAPVDSSPL
IRSNSMPTSS ATNLSVPPSL RGSHSFDERM TGSDDVFYPG TVGIPPQRML RRQAAFELPS
VQEGHMESEH PARVSKGLAS PSLKEKKLLP GDRPGYDYDV CRKPYKKWED SETLKQSYLG
SFKQGGEYFM DPSVPVQGVP TMFGTTCENR KRRKEKSVGD EEDVPMICGG MGNAPVGMMS
SEYDPKLQDG GRSGFAMTAH ESLAHGHSDR LDPARPQLPS RSPSLGSEDL PLAADPDKMT
DLGKKPPGNV ISVIQHTNSL SRPNSFERSE STEMVACPQD KTPSPAETCD SEVLEAPVSP
EWAPPGDGGE SGSKPTPSQQ VPQHSYHAQP RLVRQHNIQV PEIRVTEEPD KPEKEKEAPT
KEPEKPVEEF QWPQRSETLS QLPAEKLPPK KKRLRLADLE HSSGESSFES TGTGLSRSPS
QESNLSHSSS FSMSFDREET VKLTAPPKQD ESGKHSEFLT VPAGSYSLSV PGHHHQKEMR
RCSSEQMPCP HPTEVPEIRS KSFDYGNLSH APVAGTSPST LSPSRERKKC FLVRQASFSG
SPEIAQGEAG VDPSVKQEHM EHLHAGLRAA WSSVLPPLPG DDPGKQVGTC GPLSSGPPLH
LTQQQIMHMD SQESLRNPLI QPTSYMTSKH LPEQPHLFPH QDAVPFSPIQ NALFQFQYPT
VCMVHLPAQQ PPWWQTHFPH PFAPHPQNSY SKPPFQADLH SSYPLEHVAE HTGKKSADYP
HAKEQTYPCY SGTSGLHSKN LPLKFPSDPG SKSTETPTEQ LLREDFASEN AGPLQSLPGT
VVPVRIQTHV PSYGSVMYTS ISQILGQNSP AIVICKVDEN MTQRTLVTNA AMQGIGLNIA
QVLGQHTGLE KYPLWKVPQT LPLGLESSIP LCLPSTSDNA ASLGGSKRML SPASSLELFM
ETKQQKRVKE EKMYGQIVEE LSAVELTNSD IKKGLSRPQK PQLVRQGCAS EPKDGCFQSR
SSSFSSLSPS SSQDHPSASG PFPPNREILP GSRAPPRRKF SGPSESRESS DELDMDETSS
DMSMSPQSSA LPTGGGQQEE EGKARKLPVS MLVHMASGPG GNVANSTLLF TDVADFQQIL
QFPSLRTTTT VSWCFLNYTK PSFVQQATFK SSVYASWCIS SCNPNPSGLN TKTTLALLRS
KQKITAEIYT LAAMHRPGAG KLTSSSVWKQ FAQMKPDAPF LFGNKLERKL AGNVLKERGK
GEIHGDKDLG SKQTEPIRIK IFEGGYKSNE DYVYVRGRGR GKYICEECGI RCKKPSMLKK
HIRTHTDVRP YVCKLCNFAF KTKGNLTKHM KSKAHMKKCL ELGVSMTSVD DTETEEAENM
EELHKTSEKH SMSGISTDHQ FSDAEESDGE DGDDNDDDDE DDDDFDDQGD LTPKTRSRST
SPQPPRFSSL PVNVGAVAHG VPSDSSLGHS SLISYLVTLP SIQVTQLMTP SDSCDDTQMT
EYQRLFQSKS TDSEPDKDRL DIPSSMDEEA MLSSEPSSSP RDFSPSSYRS SPGYDSSPCR
DNSPKRYLIP KGDLSPRRHL SPRRDLSPMR HLSPRKEAAL RREMSQGDAS PRRHLSPRRP
LSPGKDITAR RDLSPRRERR YMTTIRAPSP RRALYPNPPL SMGQYLQTEP IVLGPPNLRR
GIPQVPYFSL YGDQEGAYEH HGSSLFPEGP TDYVFSHLPL HSQQQVRAPI PMVPVGGIQM
VHSLPPALSG LHPPPTLPLP TEGSEEKKGA PGEAFAKDPY ILSRRHEKQA PQVLQSSGLP
SSPSSPRLLM KQSTSEDSLN STEREQEENI QTCTKAIASL RIATEEAALL GADPPTWVQE
SPQKPLESAH VSIRHFGGPE PGQPCTSAAH PDLHDGEKDT FGTSQTAVAH PTFYSKSSVD
EKRVDFQSSK ELSLSTEEGN EPSPEKNQLH
