ZEP_ARATH
ID ZEP_ARATH Reviewed; 667 AA.
AC Q9FGC7; F4K278; Q8RXE6; Q9FDX0; Q9FS21; Q9LDB9;
DT 27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Zeaxanthin epoxidase, chloroplastic;
DE Short=AtZEP;
DE EC=1.14.15.21;
DE AltName: Full=Protein ABA DEFICIENT 1;
DE Short=AtABA1;
DE AltName: Full=Protein IMPAIRED IN BABA-INDUCED STERILITY 3;
DE AltName: Full=Protein LOW EXPRESSION OF OSMOTIC STRESS-RESPONSIVE GENES 6;
DE AltName: Full=Protein NON-PHOTOCHEMICAL QUENCHING 2;
DE Flags: Precursor;
GN Name=ZEP; Synonyms=ABA1, IBS3, LOS6, NPQ2; OrderedLocusNames=At5g67030;
GN ORFNames=K8A10.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10859185; DOI=10.1104/pp.123.2.553;
RA Iuchi S., Kobayashi M., Yamaguchi-Shinozaki K., Shinozaki K.;
RT "A stress-inducible gene for 9-cis-epoxycarotenoid dioxygenase involved in
RT abscisic acid biosynthesis under water stress in drought-tolerant cowpea.";
RL Plant Physiol. 123:553-562(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RA Giuliano G., Rosati C., Santangelo G., Nebuloso E.;
RT "Gene structure and regulation of the carotenoid biosynthesis pathway in
RT Arabidopsis thaliana.";
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=cv. Landsberg erecta; TISSUE=Seedling;
RA Audran C., Liotenberg S., Gonneau M., North H., Frey A., Tap-Waksman K.,
RA Vartanian N., Marion-Poll A.;
RT "Localization and expression of Arabidopsis thaliana zeaxanthin epoxidase:
RT contribution to the regulation of ABA biosynthesis in response to drought
RT stress and during seed developement.";
RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [7]
RP DISRUPTION PHENOTYPE.
RX PubMed=16666794; DOI=10.1104/pp.90.2.463;
RA Koornneef M., Hanhart C.J., Hilhorst H.W., Karssen C.M.;
RT "In vivo inhibition of seed development and reserve protein accumulation in
RT recombinants of abscisic acid biosynthesis and responsiveness mutants in
RT Arabidopsis thaliana.";
RL Plant Physiol. 90:463-469(1989).
RN [8]
RP FUNCTION.
RX PubMed=9668132; DOI=10.2307/3870716;
RA Niyogi K.K., Grossman A.R., Bjoerkman O.;
RT "Arabidopsis mutants define a central role for the xanthophyll cycle in the
RT regulation of photosynthetic energy conversion.";
RL Plant Cell 10:1121-1134(1998).
RN [9]
RP DISRUPTION PHENOTYPE.
RX PubMed=11124119; DOI=10.1242/dev.128.2.243;
RA Raz V., Bergervoet J.H., Koornneef M.;
RT "Sequential steps for developmental arrest in Arabidopsis seeds.";
RL Development 128:243-252(2001).
RN [10]
RP DISRUPTION PHENOTYPE.
RX PubMed=11707572; DOI=10.1073/pnas.231471998;
RA Morillon R., Chrispeels M.J.;
RT "The role of ABA and the transpiration stream in the regulation of the
RT osmotic water permeability of leaf cells.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:14138-14143(2001).
RN [11]
RP FUNCTION, TISSUE SPECIFICITY, INDUCTION, DISRUPTION PHENOTYPE, AND
RP MUTAGENESIS OF GLY-386.
RX PubMed=11779861; DOI=10.1074/jbc.m109275200;
RA Xiong L., Lee H., Ishitani M., Zhu J.-K.;
RT "Regulation of osmotic stress-responsive gene expression by the LOS6/ABA1
RT locus in Arabidopsis.";
RL J. Biol. Chem. 277:8588-8596(2002).
RN [12]
RP FUNCTION.
RX PubMed=12447533; DOI=10.1007/s00425-002-0840-3;
RA Takahashi N., Goto N., Okada K., Takahashi H.;
RT "Hydrotropism in abscisic acid, wavy, and gravitropic mutants of
RT Arabidopsis thaliana.";
RL Planta 216:203-211(2002).
RN [13]
RP DISRUPTION PHENOTYPE.
RX PubMed=12047634; DOI=10.1046/j.1365-313x.2002.01322.x;
RA Merlot S., Mustilli A.-C., Genty B., North H., Lefebvre V., Sotta B.,
RA Vavasseur A., Giraudat J.;
RT "Use of infrared thermal imaging to isolate Arabidopsis mutants defective
RT in stomatal regulation.";
RL Plant J. 30:601-609(2002).
RN [14]
RP FUNCTION.
RX PubMed=14722117; DOI=10.1074/jbc.m311154200;
RA Havaux M., Dall'Osto L., Cuine S., Giuliano G., Bassi R.;
RT "The effect of zeaxanthin as the only xanthophyll on the structure and
RT function of the photosynthetic apparatus in Arabidopsis thaliana.";
RL J. Biol. Chem. 279:13878-13888(2004).
RN [15]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=15548743; DOI=10.1105/tpc.104.025833;
RA Anderson J.P., Badruzsaufari E., Schenk P.M., Manners J.M., Desmond O.J.,
RA Ehlert C., Maclean D.J., Ebert P.R., Kazan K.;
RT "Antagonistic interaction between abscisic acid and jasmonate-ethylene
RT signaling pathways modulates defense gene expression and disease resistance
RT in Arabidopsis.";
RL Plant Cell 16:3460-3479(2004).
RN [16]
RP FUNCTION.
RX PubMed=15053765; DOI=10.1111/j.1365-313x.2004.02028.x;
RA Ton J., Mauch-Mani B.;
RT "Beta-amino-butyric acid-induced resistance against necrotrophic pathogens
RT is based on ABA-dependent priming for callose.";
RL Plant J. 38:119-130(2004).
RN [17]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=15983017; DOI=10.1093/jxb/eri206;
RA Barrero J.M., Piqueras P., Gonzalez-Guzman M., Serrano R., Rodriguez P.L.,
RA Ponce M.R., Micol J.L.;
RT "A mutational analysis of the ABA1 gene of Arabidopsis thaliana highlights
RT the involvement of ABA in vegetative development.";
RL J. Exp. Bot. 56:2071-2083(2005).
RN [18]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=15722464; DOI=10.1105/tpc.104.029728;
RA Ton J., Jakab G., Toquin V., Flors V., Iavicoli A., Maeder M.N.,
RA Metraux J.-P., Mauch-Mani B.;
RT "Dissecting the beta-aminobutyric acid-induced priming phenomenon in
RT Arabidopsis.";
RL Plant Cell 17:987-999(2005).
RN [19]
RP FUNCTION.
RX PubMed=16113213; DOI=10.1104/pp.105.065698;
RA Jakab G., Ton J., Flors V., Zimmerli L., Metraux J.-P., Mauch-Mani B.;
RT "Enhancing Arabidopsis salt and drought stress tolerance by chemical
RT priming for its abscisic acid responses.";
RL Plant Physiol. 139:267-274(2005).
RN [20]
RP FUNCTION.
RX PubMed=17416642; DOI=10.1104/pp.107.095562;
RA Kalituho L., Beran K.C., Jahns P.;
RT "The transiently generated nonphotochemical quenching of excitation energy
RT in Arabidopsis leaves is modulated by zeaxanthin.";
RL Plant Physiol. 143:1861-1870(2007).
RN [21]
RP FUNCTION.
RX PubMed=18680727; DOI=10.1016/j.bbrc.2008.07.128;
RA Park H.Y., Seok H.Y., Park B.K., Kim S.H., Goh C.H., Lee B.H., Lee C.H.,
RA Moon Y.H.;
RT "Overexpression of Arabidopsis ZEP enhances tolerance to osmotic stress.";
RL Biochem. Biophys. Res. Commun. 375:80-85(2008).
RN [22]
RP FUNCTION.
RX PubMed=17996011; DOI=10.1111/j.1365-3040.2007.01759.x;
RA Barrero J.M., Rodriguez P.L., Quesada V., Alabadi D., Blazquez M.A.,
RA Boutin J.P., Marion-Poll A., Ponce M.R., Micol J.L.;
RT "The ABA1 gene and carotenoid biosynthesis are required for late
RT skotomorphogenic growth in Arabidopsis thaliana.";
RL Plant Cell Environ. 31:227-234(2008).
RN [23]
RP FUNCTION.
RX PubMed=19278749; DOI=10.1016/j.jplph.2008.12.010;
RA Nowicka B., Strzalka W., Strzalka K.;
RT "New transgenic line of Arabidopsis thaliana with partly disabled
RT zeaxanthin epoxidase activity displays changed carotenoid composition,
RT xanthophyll cycle activity and non-photochemical quenching kinetics.";
RL J. Plant Physiol. 166:1045-1056(2009).
CC -!- FUNCTION: Zeaxanthin epoxidase that plays an important role in the
CC xanthophyll cycle and abscisic acid (ABA) biosynthesis. Converts
CC zeaxanthin into antheraxanthin and subsequently violaxanthin. Required
CC for resistance to osmotic and drought stresses, ABA-dependent stomatal
CC closure, seed development and dormancy, modulation of defense gene
CC expression and disease resistance and non-photochemical quencing (NPQ).
CC Through its role in ABA biosynthesis, regulates the expression of
CC stress-responsive genes such as RD29A during osmotic stress and is
CC required for normal plant growth during vegetative development. Is
CC required for late skotomorphogenic growth through its role in the
CC xanthophyll carotenoids neoxanthin, violaxanthin and antheraxanthin
CC biosynthesis. Required for beta-aminobutyric acid (BABA)-induced
CC priming in disease resistance, tolerance to salt and drought stresses
CC and sterility. Participates in NPQ by regulating the level of
CC zeaxanthin in photosynthetic energy conversion. NPQ is a process that
CC maintains the balance between dissipation and utilization of light
CC energy to minimize the generation of oxidizing molecules and the
CC molecular damages they can generate. {ECO:0000269|PubMed:11779861,
CC ECO:0000269|PubMed:12447533, ECO:0000269|PubMed:14722117,
CC ECO:0000269|PubMed:15053765, ECO:0000269|PubMed:15548743,
CC ECO:0000269|PubMed:15722464, ECO:0000269|PubMed:15983017,
CC ECO:0000269|PubMed:16113213, ECO:0000269|PubMed:17416642,
CC ECO:0000269|PubMed:17996011, ECO:0000269|PubMed:18680727,
CC ECO:0000269|PubMed:19278749, ECO:0000269|PubMed:9668132}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=all-trans-zeaxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-
CC [ferredoxin] = all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-
CC [ferredoxin]; Xref=Rhea:RHEA:32443, Rhea:RHEA-COMP:10000, Rhea:RHEA-
CC COMP:10001, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:27547, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738,
CC ChEBI:CHEBI:35288; EC=1.14.15.21;
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000305};
CC -!- PATHWAY: Plant hormone biosynthesis; abscisate biosynthesis.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9FGC7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9FGC7-2; Sequence=VSP_041638, VSP_041639;
CC -!- TISSUE SPECIFICITY: Expressed in leaves, stems and flowers, and at
CC lower levels in roots and siliques. {ECO:0000269|PubMed:11779861}.
CC -!- INDUCTION: By ABA and drought, salt and osmotic stresses.
CC {ECO:0000269|PubMed:11779861}.
CC -!- DISRUPTION PHENOTYPE: Increased endogenous level of zeaxanthin and
CC reduced level of ABA. Reduced size of leaves, inflorescences and
CC flowers, early flowering, increased number of wilted plants, premature
CC seed germination and reduced osmotic water permeability and ability to
CC close stomata. Reduced susceptibility to virulent isolates of
CC P.parasitica and sensitivity to BABA-induced priming.
CC {ECO:0000269|PubMed:11124119, ECO:0000269|PubMed:11707572,
CC ECO:0000269|PubMed:11779861, ECO:0000269|PubMed:12047634,
CC ECO:0000269|PubMed:15548743, ECO:0000269|PubMed:15722464,
CC ECO:0000269|PubMed:15983017, ECO:0000269|PubMed:16666794}.
CC -!- MISCELLANEOUS: Plants overexpressing ZEP show increased levels of
CC violaxanthin and ABA and increased tolerance to salt and drought
CC stresses.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL91193.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC Sequence=AAO00920.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB030296; BAB11935.1; -; mRNA.
DR EMBL; AF134577; AAF82390.1; -; Genomic_DNA.
DR EMBL; AF134578; AAF82391.1; -; mRNA.
DR EMBL; AF281655; AAG17703.1; -; mRNA.
DR EMBL; AF283761; AAG38877.1; -; Genomic_DNA.
DR EMBL; AB026640; BAB08942.1; -; Genomic_DNA.
DR EMBL; CP002688; AED98292.1; -; Genomic_DNA.
DR EMBL; CP002688; AED98293.1; -; Genomic_DNA.
DR EMBL; AY081304; AAL91193.1; ALT_SEQ; mRNA.
DR EMBL; AY093145; AAM13144.1; -; mRNA.
DR EMBL; BT002560; AAO00920.1; ALT_SEQ; mRNA.
DR RefSeq; NP_201504.2; NM_126103.2. [Q9FGC7-2]
DR RefSeq; NP_851285.1; NM_180954.3. [Q9FGC7-1]
DR AlphaFoldDB; Q9FGC7; -.
DR SMR; Q9FGC7; -.
DR STRING; 3702.AT5G67030.1; -.
DR PaxDb; Q9FGC7; -.
DR PRIDE; Q9FGC7; -.
DR ProteomicsDB; 242947; -. [Q9FGC7-1]
DR EnsemblPlants; AT5G67030.1; AT5G67030.1; AT5G67030. [Q9FGC7-1]
DR EnsemblPlants; AT5G67030.2; AT5G67030.2; AT5G67030. [Q9FGC7-2]
DR GeneID; 836838; -.
DR Gramene; AT5G67030.1; AT5G67030.1; AT5G67030. [Q9FGC7-1]
DR Gramene; AT5G67030.2; AT5G67030.2; AT5G67030. [Q9FGC7-2]
DR KEGG; ath:AT5G67030; -.
DR Araport; AT5G67030; -.
DR TAIR; locus:2158083; AT5G67030.
DR eggNOG; KOG2614; Eukaryota.
DR HOGENOM; CLU_009665_16_1_1; -.
DR InParanoid; Q9FGC7; -.
DR OMA; SCKDGAF; -.
DR OrthoDB; 521070at2759; -.
DR PhylomeDB; Q9FGC7; -.
DR BioCyc; MetaCyc:AT5G67030-MON; -.
DR BRENDA; 1.14.15.21; 399.
DR UniPathway; UPA00090; -.
DR PRO; PR:Q9FGC7; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FGC7; baseline and differential.
DR Genevisible; Q9FGC7; AT.
DR GO; GO:0009507; C:chloroplast; HDA:TAIR.
DR GO; GO:0009941; C:chloroplast envelope; HDA:TAIR.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0009536; C:plastid; HDA:TAIR.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0052662; F:zeaxanthin epoxidase activity; IEA:UniProtKB-EC.
DR GO; GO:0009688; P:abscisic acid biosynthetic process; TAS:TAIR.
DR GO; GO:0009408; P:response to heat; IMP:TAIR.
DR GO; GO:0010114; P:response to red light; IEP:TAIR.
DR GO; GO:0009414; P:response to water deprivation; IMP:TAIR.
DR GO; GO:0010182; P:sugar mediated signaling pathway; TAS:TAIR.
DR GO; GO:0016123; P:xanthophyll biosynthetic process; IMP:TAIR.
DR CDD; cd00060; FHA; 1.
DR Gene3D; 3.50.50.60; -; 1.
DR InterPro; IPR002938; FAD-bd.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR017079; Zeaxanthin_epoxidase.
DR Pfam; PF01494; FAD_binding_3; 2.
DR Pfam; PF00498; FHA; 1.
DR PIRSF; PIRSF036989; Zeaxanthin_epoxidase; 1.
DR SMART; SM00240; FHA; 1.
DR SUPFAM; SSF49879; SSF49879; 1.
DR SUPFAM; SSF51905; SSF51905; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Abscisic acid biosynthesis; Alternative splicing; Chloroplast; FAD;
KW Flavoprotein; Oxidoreductase; Plastid; Reference proteome; Stress response;
KW Transit peptide.
FT TRANSIT 1..59
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 60..667
FT /note="Zeaxanthin epoxidase, chloroplastic"
FT /id="PRO_0000412072"
FT DOMAIN 558..612
FT /note="FHA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00086"
FT BINDING 82..110
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000255"
FT BINDING 360..373
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000255"
FT VAR_SEQ 581..610
FT /note="SKMHARVIYKDGAFFLMDLRSEHGTYVTDN -> YKLYACSCDLQRRSFLLD
FT GSSKRTRNLCDR (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_041638"
FT VAR_SEQ 611..667
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_041639"
FT MUTAGEN 125
FT /note="P->A: In aba1-3; ABA-deficient phenotype."
FT MUTAGEN 160
FT /note="G->S: In aba1-6; ABA-deficient phenotype."
FT MUTAGEN 386
FT /note="G->E: In los6; reduces plant size, accelerates
FT flowering and increases transpirational water loss."
FT /evidence="ECO:0000269|PubMed:11779861"
FT CONFLICT 29
FT /note="S -> A (in Ref. 3; AAG17703/AAG38877)"
FT /evidence="ECO:0000305"
FT CONFLICT 42..54
FT /note="KPGGVSGFRSRRA -> RSGGGLSVFRSRKT (in Ref. 3;
FT AAG17703/AAG38877)"
FT /evidence="ECO:0000305"
FT CONFLICT 76
FT /note="E -> D (in Ref. 2; AAF82390/AAF82391)"
FT /evidence="ECO:0000305"
FT CONFLICT 77
FT /note="Missing (in Ref. 3; AAG17703/AAG38877)"
FT /evidence="ECO:0000305"
FT CONFLICT 116
FT /note="I -> M (in Ref. 2; AAF82390/AAF82391)"
FT /evidence="ECO:0000305"
FT CONFLICT 180..182
FT /note="ASR -> GVT (in Ref. 2; AAF82390/AAF82391)"
FT /evidence="ECO:0000305"
FT CONFLICT 194
FT /note="T -> I (in Ref. 1; BAB11935)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 667 AA; 73842 MW; 89A0A6E6B8A26D5D CRC64;
MGSTPFCYSI NPSPSKLDFT RTHVFSPVSK QFYLDLSSFS GKPGGVSGFR SRRALLGVKA
ATALVEKEEK REAVTEKKKK SRVLVAGGGI GGLVFALAAK KKGFDVLVFE KDLSAIRGEG
KYRGPIQIQS NALAALEAID IEVAEQVMEA GCITGDRING LVDGISGTWY VKFDTFTPAA
SRGLPVTRVI SRMTLQQILA RAVGEDVIRN ESNVVDFEDS GDKVTVVLEN GQRYEGDLLV
GADGIWSKVR NNLFGRSEAT YSGYTCYTGI ADFIPADIES VGYRVFLGHK QYFVSSDVGG
GKMQWYAFHE EPAGGADAPN GMKKRLFEIF DGWCDNVLDL LHATEEEAIL RRDIYDRSPG
FTWGKGRVTL LGDSIHAMQP NMGQGGCMAI EDSFQLALEL DEAWKQSVET TTPVDVVSSL
KRYEESRRLR VAIIHAMARM AAIMASTYKA YLGVGLGPLS FLTKFRVPHP GRVGGRFFVD
IAMPSMLDWV LGGNSEKLQG RPPSCRLTDK ADDRLREWFE DDDALERTIK GEWYLIPHGD
DCCVSETLCL TKDEDQPCIV GSEPDQDFPG MRIVIPSSQV SKMHARVIYK DGAFFLMDLR
SEHGTYVTDN EGRRYRATPN FPARFRSSDI IEFGSDKKAA FRVKVIRKTP KSTRKNESNN
DKLLQTA
