ID   ZER1_CAEEL              Reviewed;         895 AA.
AC   Q2WF59; Q2WF58;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Zyg eleven-related protein 1;
DE   AltName: Full=zyg-11-related protein;
GN   Name=zer-1; ORFNames=T24C4.6;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION, INTERACTION WITH ELC-1, IDENTIFICATION IN COMPLEX WITH CUL-2 AND
RP   ELC-1, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=17304241; DOI=10.1038/sj.embor.7400895;
RA   Vasudevan S., Starostina N.G., Kipreos E.T.;
RT   "The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved
RT   family of CUL-2 complex components.";
RL   EMBO Rep. 8:279-286(2007).
CC   -!- FUNCTION: Acts as target recruitment subunit in the E3 ubiquitin ligase
CC       complex zer-1-cul-2-elc-1. {ECO:0000269|PubMed:17304241}.
CC   -!- SUBUNIT: Interacts with elc-1. Part of an E3 ubiquitin ligase complex
CC       including zer-11, cul-2 and elc-1. {ECO:0000269|PubMed:17304241}.
CC   -!- INTERACTION:
CC       Q2WF59; Q17390: cul-2; NbExp=2; IntAct=EBI-1811352, EBI-1811231;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=b;
CC         IsoId=Q2WF59-1; Sequence=Displayed;
CC       Name=a;
CC         IsoId=Q2WF59-2; Sequence=VSP_028229;
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DR   EMBL; FO081214; CCD69960.1; -; Genomic_DNA.
DR   EMBL; FO081214; CCD69961.1; -; Genomic_DNA.
DR   RefSeq; NP_741089.2; NM_171078.6. [Q2WF59-1]
DR   RefSeq; NP_741090.3; NM_171079.7. [Q2WF59-2]
DR   AlphaFoldDB; Q2WF59; -.
DR   SMR; Q2WF59; -.
DR   BioGRID; 40518; 3.
DR   IntAct; Q2WF59; 2.
DR   MINT; Q2WF59; -.
DR   STRING; 6239.T24C4.6b; -.
DR   EPD; Q2WF59; -.
DR   PaxDb; Q2WF59; -.
DR   PeptideAtlas; Q2WF59; -.
DR   EnsemblMetazoa; T24C4.6a.1; T24C4.6a.1; WBGene00020762. [Q2WF59-2]
DR   EnsemblMetazoa; T24C4.6a.2; T24C4.6a.2; WBGene00020762. [Q2WF59-2]
DR   EnsemblMetazoa; T24C4.6b.1; T24C4.6b.1; WBGene00020762. [Q2WF59-1]
DR   GeneID; 175249; -.
DR   KEGG; cel:CELE_T24C4.6; -.
DR   UCSC; T24C4.6a; c. elegans. [Q2WF59-1]
DR   CTD; 175249; -.
DR   WormBase; T24C4.6a; CE39414; WBGene00020762; zer-1. [Q2WF59-2]
DR   WormBase; T24C4.6b; CE39415; WBGene00020762; zer-1. [Q2WF59-1]
DR   eggNOG; KOG3665; Eukaryota.
DR   GeneTree; ENSGT00530000063187; -.
DR   InParanoid; Q2WF59; -.
DR   OMA; FRNKWNI; -.
DR   OrthoDB; 374821at2759; -.
DR   PhylomeDB; Q2WF59; -.
DR   PRO; PR:Q2WF59; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00020762; Expressed in embryo and 4 other tissues.
DR   GO; GO:0031462; C:Cul2-RING ubiquitin ligase complex; IDA:UniProtKB.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR040368; Zer-1.
DR   PANTHER; PTHR12904:SF23; PTHR12904:SF23; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..895
FT                   /note="Zyg eleven-related protein 1"
FT                   /id="PRO_0000305091"
FT   REGION          58..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          195..221
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        204..221
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         838..895
FT                   /note="RNPKSIPADLAHSSNSPTFVPSYVSDVEEEDEGDVEADEEVQDFVNVDFDDY
FT                   ALPMEY -> ARKAAIRPQKRSRDPADDGDDEY (in isoform a)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_028229"
SQ   SEQUENCE   895 AA;  101124 MW;  9713C1B260C884C3 CRC64;
     MSHTADIPLE APTLLKLASS SVQSQINNDE YMETVILPVP LSQELFARFR NKWNIHNHGP
     APVEHLGPPT DEPRPDQGNI DMIKQVFRIW SDSTRLPLEK LNLTGATVDD QIFVDLLHAH
     AHSITELDLT NVTGVTDLSN AYLYARSTHF PMLTSIRMTS MDLVTGHQPR RKNGIASTEF
     RALFMLGEEA LAEARGQMER DGLRSPLSPS SQPSSIQSDH QSLDALVPCD SPVEPPLITA
     RAPNVKRLFL PRCPAKRTTI DEEEQNTHVI LTKILSPLQQ LEVLDLSYWS KTDDMRCLQP
     LSNTLTCLIL YDVPDLYHAV PNICHMTELR ILDVSQSNRD SGLYPHPVTT LNKLIVSLKY
     LTHLDISSTN LATQPSSHDN PARYRESVRT DICGLQSLVR PLKYLGLFNC ESASHVREIP
     AEVVSGDANE DQVITSLQMY KDRAGLLQNV LNESYQLYRF GNSNPLTRHT EALHLVLEAM
     HRHLADSTLQ IAGSASLFYI IRKVDMNRDT KRRVVSALLS GMEVHMEEQV MVRNCCLSLC
     QFEIPQDILF DYSRLAVLLV SVLQHHNADN LTQRIVVFLL NSMACHVEGD QKVQVGSYGA
     IEMILDQIAR KHTANVCDDV MEVGWSFLWN ITDETPVNCE LFLNANGLDL FQKCYEAFKT
     ERELVRNMMG LIGNIAEVDE LRSQLMKDDY VKIFCALLES QEESIEISYN SAGVLAHMVS
     DGEEVWKQMT VCRNEVMQRI VEATSSWKLA TRRFINYRSF RPILRLLPLY HAYASQHWAV
     WALANLTTTD GEKYCAYVRD EGGVPLLEEL VSNAITTTDI RTLANTVLEN IRNVENKRNP
     KSIPADLAHS SNSPTFVPSY VSDVEEEDEG DVEADEEVQD FVNVDFDDYA LPMEY