ZER1_DROME
ID ZER1_DROME Reviewed; 793 AA.
AC Q9W0E8;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Protein zer-1 homolog;
DE AltName: Full=Zyg-11 homolog B-like protein;
GN ORFNames=CG12084;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=17304241; DOI=10.1038/sj.embor.7400895;
RA Vasudevan S., Starostina N.G., Kipreos E.T.;
RT "The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved
RT family of CUL-2 complex components.";
RL EMBO Rep. 8:279-286(2007).
CC -!- FUNCTION: Serves as substrate adapter subunit in an E3 ubiquitin ligase
CC complex CG12084-cul-2-elongin BC. Targets substrates bearing N-terminal
CC glycine degrons for proteasomal degradation.
CC {ECO:0000250|UniProtKB:Q7Z7L7}.
CC -!- SIMILARITY: Belongs to the zyg-11 family. {ECO:0000305}.
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DR EMBL; AE014296; AAF47500.2; -; Genomic_DNA.
DR EMBL; AY128434; AAM75027.1; -; mRNA.
DR RefSeq; NP_612112.1; NM_138268.2.
DR AlphaFoldDB; Q9W0E8; -.
DR SMR; Q9W0E8; -.
DR BioGRID; 72971; 9.
DR IntAct; Q9W0E8; 6.
DR STRING; 7227.FBpp0072595; -.
DR PaxDb; Q9W0E8; -.
DR PRIDE; Q9W0E8; -.
DR DNASU; 192509; -.
DR EnsemblMetazoa; FBtr0072711; FBpp0072595; FBgn0043458.
DR GeneID; 192509; -.
DR KEGG; dme:Dmel_CG12084; -.
DR UCSC; CG12084-RA; d. melanogaster.
DR FlyBase; FBgn0043458; CG12084.
DR VEuPathDB; VectorBase:FBgn0043458; -.
DR eggNOG; KOG3665; Eukaryota.
DR GeneTree; ENSGT00530000063187; -.
DR InParanoid; Q9W0E8; -.
DR OMA; MFDAPAS; -.
DR PhylomeDB; Q9W0E8; -.
DR BioGRID-ORCS; 192509; 0 hits in 1 CRISPR screen.
DR ChiTaRS; CG12084; fly.
DR GenomeRNAi; 192509; -.
DR PRO; PR:Q9W0E8; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0043458; Expressed in brain and 27 other tissues.
DR ExpressionAtlas; Q9W0E8; baseline and differential.
DR Genevisible; Q9W0E8; DM.
DR GO; GO:0031462; C:Cul2-RING ubiquitin ligase complex; ISS:UniProtKB.
DR Gene3D; 1.25.10.10; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR040368; Zer-1.
DR PANTHER; PTHR12904:SF23; PTHR12904:SF23; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Reference proteome; Repeat; Ubl conjugation pathway.
FT CHAIN 1..793
FT /note="Protein zer-1 homolog"
FT /id="PRO_0000305092"
FT REPEAT 84..108
FT /note="LRR 1"
FT REPEAT 187..210
FT /note="LRR 2"
FT REPEAT 269..294
FT /note="LRR 3"
SQ SEQUENCE 793 AA; 90366 MW; 2F4F43B3475A56DE CRC64;
MSCKVRLMED GSLDEEPLTL KEIAYQKLCN NLDIISSHRP DGQRGLNPGI VLPNEICDGF
LENYQRFNRP LDDSVIRLFE DTHRTSLKIV NLRNSTLSSI GLETLMRHKL FALSLWYCDM
ISVGSHHLLA HYGDSLRSLE LGISSHLLQY AEPNEKEPVD FQLTCPHLRR LVLNGVVMHH
RLQFAHLHDL GHLDLTSCVL ANFSLEALGS LPNLHTLILF NVWPIANQLH AICCLRRLCT
LDISISSSGN GHGTYDLPDQ TLEMLMDNLR HLTHLDISGT NLAGNGVATK ESTTTSGMQQ
SPKMEQHFAL TDIPGLASRT QRPLQFLGLY HTAHWACKRH DIPALEVAGD ANEQQILTAA
RYYHDRPVLL TRVLNDLYHL FRFENCKDIH TALDVVLSAM DRHLKFKHMQ ISGSATLFYI
VKGRDRSKFG ALLRNHIIRT LLNGMEMHIT DDTMLRNGYL TLTQFHMPVD VLFEYERLIK
ILLHGVSKTE QEGFVQRIAI YLLNTLACQV DGRQKLFLGE LGVVSTMFTL IKDRLTRSVF
DDVMEVAWST MWNVTDETAI NCKRFLDGRG MEYFLKCLHT FPDRDELLRN MMGLLGNVAE
VKWLRPKLMT QEFIEVFARL LDSLSDGIEV GGASASVVAR VREREMASAN HAYLRFQVSY
NAAGVLAHIA SDGADAWTIK TPSREHVLER MVAAIQRWNI KSERNINYRS FEPILSLVRC
YETPQCQHWA VWALANLTQV YPEKYCKLVE QENGIQILNE LIEHESPYCE IKRIARLVIE
QCDSGSERMV VDG
