ZEST_DROSE
ID ZEST_DROSE Reviewed; 268 AA.
AC P67855; Q24597; Q24598; Q24599; Q24600; Q24601; Q24602; Q24603; Q24604;
AC Q27387;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 48.
DE RecName: Full=Regulatory protein zeste;
DE Flags: Fragment;
GN Name=z;
OS Drosophila sechellia (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7238;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C1, C2, P1, P2, P3, and P4;
RX PubMed=8355601; DOI=10.1093/oxfordjournals.molbev.a040044;
RA Hey J., Kliman R.M.;
RT "Population genetics and phylogenetics of DNA sequence variation at
RT multiple loci within the Drosophila melanogaster species complex.";
RL Mol. Biol. Evol. 10:804-822(1993).
CC -!- FUNCTION: Involved in transvection phenomena (= synapsis-dependent gene
CC expression), where the synaptic pairing of chromosomes carrying genes
CC with which zeste interacts influences the expression of these genes.
CC Zeste binds to DNA and stimulates transcription from a nearby promoter
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Self-associates forming complexes of several hundred monomers.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; L13061; AAA29044.1; -; Genomic_DNA.
DR EMBL; L13062; AAA29045.1; -; Genomic_DNA.
DR EMBL; L13063; AAA29046.1; -; Genomic_DNA.
DR EMBL; L13064; AAA29047.1; -; Genomic_DNA.
DR EMBL; L13065; AAA29048.1; -; Genomic_DNA.
DR EMBL; L13066; AAA29049.1; -; Genomic_DNA.
DR AlphaFoldDB; P67855; -.
DR SMR; P67855; -.
DR EnsemblMetazoa; FBtr0202212; FBpp0200704; FBgn0012801.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR InterPro; IPR028002; Myb_DNA-bind_5.
DR Pfam; PF13873; Myb_DNA-bind_5; 1.
PE 3: Inferred from homology;
KW DNA-binding; Nucleus; Transcription; Transcription regulation.
FT CHAIN <1..>268
FT /note="Regulatory protein zeste"
FT /id="PRO_0000066574"
FT DNA_BIND <1..72
FT /evidence="ECO:0000250"
FT REGION 94..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..124
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT NON_TER 268
SQ SEQUENCE 268 AA; 30353 MW; F592F8FA4F2DB47B CRC64;
TAEEKEVLYT LFHLHEEVID IKHRKKQRNK YSVRETWDKI VKDFNSHPHV SAMRNIKQIQ
KFWLNSRLRK QYPYRDGSSS NLSSGSAKIS SVSVSVASAV PQQQQQQHHQ QHDNVKEEPE
YQISPDASEH NPQADTFDEI EMDANDVSEI DEDPMEQQQQ QQQEAQAQAQ AQAQVQSAAA
EMQKMQQVNA VAVAAAAAAN ATMINTHQIN VDQISAEKLT LNDLLHFKTA RPREEIILQI
KHPSEATATQ IHTIPTQAQQ HPMATITA