ID   ZEST_DROSI              Reviewed;         268 AA.
AC   P67856; Q24597; Q24598; Q24599; Q24600; Q24601; Q24602; Q24603; Q24604;
AC   Q27387;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Regulatory protein zeste;
DE   Flags: Fragment;
GN   Name=z;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CA1, CA2, K1, K2, LI1, and LI2;
RX   PubMed=8355601; DOI=10.1093/oxfordjournals.molbev.a040044;
RA   Hey J., Kliman R.M.;
RT   "Population genetics and phylogenetics of DNA sequence variation at
RT   multiple loci within the Drosophila melanogaster species complex.";
RL   Mol. Biol. Evol. 10:804-822(1993).
CC   -!- FUNCTION: Involved in transvection phenomena (= synapsis-dependent gene
CC       expression), where the synaptic pairing of chromosomes carrying genes
CC       with which zeste interacts influences the expression of these genes.
CC       Zeste binds to DNA and stimulates transcription from a nearby promoter
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Self-associates forming complexes of several hundred monomers.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; L13049; AAA29032.1; -; Genomic_DNA.
DR   EMBL; L13050; AAA29033.1; -; Genomic_DNA.
DR   EMBL; L13051; AAA29034.1; -; Genomic_DNA.
DR   EMBL; L13052; AAA29035.1; -; Genomic_DNA.
DR   EMBL; L13053; AAA29036.1; -; Genomic_DNA.
DR   EMBL; L13055; AAA29038.1; -; Genomic_DNA.
DR   AlphaFoldDB; P67856; -.
DR   SMR; P67856; -.
DR   EnsemblMetazoa; FBtr0216518; FBpp0215010; FBgn0012904.
DR   Bgee; FBgn0012904; Expressed in embryo and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR028002; Myb_DNA-bind_5.
DR   Pfam; PF13873; Myb_DNA-bind_5; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Nucleus; Transcription; Transcription regulation.
FT   CHAIN           <1..>268
FT                   /note="Regulatory protein zeste"
FT                   /id="PRO_0000066575"
FT   DNA_BIND        <1..72
FT                   /evidence="ECO:0000250"
FT   REGION          94..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        94..109
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        110..124
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         105..106
FT                   /note="Missing (in strain: K2)"
FT   NON_TER         1
FT   NON_TER         268
SQ   SEQUENCE   268 AA;  30353 MW;  F592F8FA4F2DB47B CRC64;
     TAEEKEVLYT LFHLHEEVID IKHRKKQRNK YSVRETWDKI VKDFNSHPHV SAMRNIKQIQ
     KFWLNSRLRK QYPYRDGSSS NLSSGSAKIS SVSVSVASAV PQQQQQQHHQ QHDNVKEEPE
     YQISPDASEH NPQADTFDEI EMDANDVSEI DEDPMEQQQQ QQQEAQAQAQ AQAQVQSAAA
     EMQKMQQVNA VAVAAAAAAN ATMINTHQIN VDQISAEKLT LNDLLHFKTA RPREEIILQI
     KHPSEATATQ IHTIPTQAQQ HPMATITA