ZF316_MOUSE
ID ZF316_MOUSE Reviewed; 1016 AA.
AC Q6PGE4;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 126.
DE RecName: Full=Zinc finger protein 316;
GN Name=Znf316; Synonyms=Zfp316;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; BC057078; AAH57078.1; -; mRNA.
DR RefSeq; NP_059495.3; NM_017467.3.
DR AlphaFoldDB; Q6PGE4; -.
DR SMR; Q6PGE4; -.
DR STRING; 10090.ENSMUSP00000125416; -.
DR iPTMnet; Q6PGE4; -.
DR PhosphoSitePlus; Q6PGE4; -.
DR MaxQB; Q6PGE4; -.
DR PaxDb; Q6PGE4; -.
DR PRIDE; Q6PGE4; -.
DR DNASU; 54201; -.
DR GeneID; 54201; -.
DR KEGG; mmu:54201; -.
DR CTD; 54201; -.
DR MGI; MGI:1860402; Zfp316.
DR eggNOG; KOG1721; Eukaryota.
DR InParanoid; Q6PGE4; -.
DR OMA; EPIMGSP; -.
DR OrthoDB; 1318335at2759; -.
DR BioGRID-ORCS; 54201; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Zfp316; mouse.
DR PRO; PR:Q6PGE4; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q6PGE4; protein.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 13.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 15.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..1016
FT /note="Zinc finger protein 316"
FT /id="PRO_0000348943"
FT DOMAIN 154..225
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 340..362
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 368..390
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 396..418
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 424..446
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 452..474
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 480..502
FT /note="C2H2-type 6; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 707..729
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 735..757
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 763..785
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 791..813
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 819..841
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 847..869
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 875..897
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 903..925
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 931..953
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 541..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 950..1016
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..52
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..93
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..147
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..558
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..599
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1016 AA; 110812 MW; 4ECD3B08911187B9 CRC64;
MAALQSAPDS PATQLEPAED GSECDADPEE EEEEEQQEEE DEEEEEEVVV EEVATPVQEV
AEVEVEANSA DNGGGDDDDD GGGGDDDVEE VLAEEQTLSL GTQERHSNGG HAKAPVLQGK
ALQTSRVSPT TQDEDVEEEE EEEDEEHFLT QGLVTFEDVA VYFSLEEWER LGVDQRDLYR
EVMQENYGIL VSLGYPIPKP DLIFHLEQGE EPWVEDGPHP EEGDVVTGVY TGAWFWNDDI
EDHEEEDDED FLAEVAEEEN EPPGLWSAAY GVGDVPGTWG PDDSDSVQTP EGWGPNPGSL
GILAEEVEAK HFLSGREPGE NFLVPWAFPA VAVPIGCPET TCDVCGKVFP HRSRLAKHQR
YHAAVKPFGC DECGKGFVYR SHLAIHQRTH TGEKPFPCPD CGKRFVYKSH LVTHRRIHTG
ERPYRCVFCG AGFGRRSYLV THQRTHTGER PYPCLHCGRS FSQSSALARH QAVHTADRPH
CCPDCGQAFR LRADFQRHRR SGGCTEPSSG DGARMAPHEV GMAPNEVEMA VAAVATVEPE
ELEAAPAETE EPEAGVADGD TEAEARQDEQ VVVAPAAEAT VPDSKKDPEP DRRFREMGNG
LAEGEGPSSH PFGFHFPMHP KSWLHPDGFP ILGFPEFSER LQADGRHLPG PLGSPLSLQG
MGLACDPFRS VGPGAGVDGG LRAFPPAVRS LLSEPAPAAL AEEESPWICS DCGKTFGRRA
ALAKHQRYHA GERPHRCADC GKSFVYGSHL ARHRRTHTGE RPFPCPECGA RFARGSHLAA
HVRGHTGEKP FVCGVCGAGF SRRAHLTAHG RAHTGERPYA CAECGRRFGQ SAALTRHQWA
HAEEKPHRCP DCGKGFGHSS DFKRHRRTHT GEKPFRCADC GRGFAQRSNL AKHRRGHTGE
RPFPCPECGK RFSQRSVLVT HQRTHTGERP YLCSNCGRRF SQSSHLLTHM KTHRGPGSAP
AHTSSTKAQA PAKATPPLPP PGSGSGTLLE FAGGTSFGSD PAAFAGPSGS YEESIL
