CC174_MOUSE
ID CC174_MOUSE Reviewed; 467 AA.
AC Q3U155; Q80XC8; Q8CA20;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=Coiled-coil domain-containing protein 174;
GN Name=Ccdc174;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NOD; TISSUE=Spleen, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probably involved in neuronal development.
CC {ECO:0000250|UniProtKB:Q6PII3}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6PII3}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK039818; BAC30460.1; -; mRNA.
DR EMBL; AK156259; BAE33645.1; -; mRNA.
DR EMBL; BC051147; AAH51147.1; -; mRNA.
DR CCDS; CCDS20370.2; -.
DR RefSeq; NP_766318.2; NM_172730.2.
DR AlphaFoldDB; Q3U155; -.
DR SMR; Q3U155; -.
DR STRING; 10090.ENSMUSP00000049280; -.
DR iPTMnet; Q3U155; -.
DR PhosphoSitePlus; Q3U155; -.
DR EPD; Q3U155; -.
DR MaxQB; Q3U155; -.
DR PaxDb; Q3U155; -.
DR PeptideAtlas; Q3U155; -.
DR PRIDE; Q3U155; -.
DR ProteomicsDB; 265584; -.
DR DNASU; 232236; -.
DR GeneID; 232236; -.
DR KEGG; mmu:232236; -.
DR UCSC; uc009cyk.1; mouse.
DR CTD; 51244; -.
DR MGI; MGI:2444652; Ccdc174.
DR eggNOG; ENOG502QWJ9; Eukaryota.
DR InParanoid; Q3U155; -.
DR OrthoDB; 1585377at2759; -.
DR TreeFam; TF323679; -.
DR BioGRID-ORCS; 232236; 20 hits in 72 CRISPR screens.
DR PRO; PR:Q3U155; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q3U155; protein.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR InterPro; IPR025066; CCDC174-like.
DR PANTHER; PTHR15885; PTHR15885; 1.
DR Pfam; PF13300; DUF4078; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..467
FT /note="Coiled-coil domain-containing protein 174"
FT /id="PRO_0000251957"
FT REGION 47..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 301..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 64..99
FT /evidence="ECO:0000255"
FT COILED 268..310
FT /evidence="ECO:0000255"
FT COMPBIAS 301..325
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..365
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 198
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6PII3"
FT CONFLICT 120
FT /note="V -> D (in Ref. 2; AAH51147)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 467 AA; 53942 MW; 0C704AF154E68E8D CRC64;
MDRKKKPLDV TASSLVDLKA ELFRKQEEFK QEKLLKDSGV FGKPKTINKK PSIWSKQNAG
VTSRAEKDAE QKLEEQKTLD KAREKLEEKA KLYEKMTKGD FLDEEVEDMY LVDFTQKIIV
KRKEMEVLGA TRESQIEEER DDDDKEEFSD KDIPPPQDPS EEWVDYVDSL GRSRRCMRKD
LPSLLEMDKN LQGRLFVSPA NEKTLLSEDM RKELQRQQWE EEEREALKKP MGPIHYEDIR
ENEARQLGVG YFAFARDKEL RNKQMKTLEM LREQTTDQRI KRENIKEKRK AMLEARLAKL
RQKKMKKSKE DGTEEEGREA DGVVPEPSEP KPVPAPAPVA QNSKVEVIIQ ERRDTKPGVP
HIREWDRGKD FSFGFWSKKQ SELRAERDPE FAPPSNYFVG QKRTAPMSSQ PQSRPGSAPS
DLGHSSGQSQ EPSSSHTSTP ASESSPQAPT VTFQTLDDMI SYYKQVT
